MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2101 to 2150 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
1051	17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	no value	Divided	211.449	217.998	1.03097
	annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	ANXA11	Subtracted	219.673	213.378	6.295
1052	lysyl-trna synthetase (ec 6.1.1.6) (lysine--trna ligase) (lysrs). [swissprot;acc:q15046]	KARS		220.291	226.584	6.293
	retinol dehydrogenase 8 (all-trans); photoreceptor outer segment all-trans retinol dehydrogenase. [refseq;acc:nm_015725]	RDH8	Divided	211.449	217.998	1.03097
1053	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	ANXA7	Subtracted	219.655	213.385	6.27
	proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066]	PSMA5	Divided	207.04	200.84	1.03087
1054	60s ribosomal protein l21. [swissprot;acc:p46778]	no value		223.958	217.263	1.03082
	proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066]	PSMA5	Subtracted	207.04	200.84	6.2
1055	hcv ns3-transactivated protein 1. [refseq;acc:nm_019048]	ASNSD1	Divided	219.01	212.468	1.03079
	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	NFU1	Subtracted	138.705	132.538	6.167
1056	methyltransferase like 2. [refseq;acc:nm_018396]	no value		147.211	153.371	6.16
	vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606]	ATP6V1A	Divided	219.01	212.468	1.03079
1057	asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]	ASNS
	cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763]	DYNLT1	Subtracted	147.211	153.371	6.16
1058	ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245]	ATXN2L	Divided	228.105	221.293	1.03078
	fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	FZR1	Subtracted	147.211	153.371	6.16
1059	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	no value	Divided	228.105	221.293	1.03078
	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]	PCSK5	Subtracted	147.211	153.371	6.16
1060	nemo-like kinase; likely ortholog of mouse nemo like kinase. [refseq;acc:nm_016231]	NLK	Divided	218.162	211.648	1.03078
	septin 6. [swissprot;acc:q14141]	SEPT6	Subtracted	126.604	120.463	6.141
1061	adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]	AP3M1		217.323	211.185	6.138
	elks protein. [refseq;acc:nm_015064]	ERC1	Divided	218.162	211.648	1.03078
1062	brain protein 44. [swissprot;acc:o95563]	BRP44	Subtracted	126.215	120.078	6.137
	zinc finger protein 174 (aw-1). [swissprot;acc:q15697]	ZNF174	Divided	269.963	278.239	1.03066
1063	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	SEPT7	Subtracted	126.215	120.078	6.137
	zinc finger imprinted 2. [swissprot;acc:q9nzv7]	no value	Divided	269.96	278.232	1.03064
1064	adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	AP3M2	Subtracted	217.315	211.183	6.132
	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	ZNF24	Divided	269.955	278.221	1.03062
1065	septin 10 isoform 1. [refseq;acc:nm_144710]	SEPT10	Subtracted	125.526	119.402	6.124
	zinc finger protein 305. [swissprot;acc:o43309]	ZSCAN12	Divided	269.954	278.219	1.03062
1066	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	SEPT8	Subtracted	124.434	118.318	6.116
	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	ZNF18	Divided	269.956	278.223	1.03062
1067	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	GTPBP3	Subtracted	213.552	207.463	6.089
	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	ZNF215	Divided	269.956	278.223	1.03062
1068	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]	NDUFB9	Subtracted	212.345	206.339	6.006
	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	ZNF274	Divided	269.953	278.215	1.03061
1069	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	DPH1	Subtracted	229.243	235.246	6.003
	zinc finger protein 232. [swissprot;acc:q9uny5]	ZNF232	Divided	269.954	278.218	1.03061
1070	arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]	GIT2	Subtracted	216.78	222.782	6.002
	zinc finger protein 99. [refseq;acc:nm_032164]	ZNF394	Divided	269.954	278.218	1.03061
1071	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]	no value		231.277	238.356
	u3 small nucleolar ribonucleoprotein protein mpp10 (m phase phosphoprotein 10). [swissprot;acc:o00566]	MPHOSPH10	Subtracted	241.496	235.508	5.988
1072	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]	PPA1		224.307	230.242	5.935
	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	ZNF213	Divided	269.954	278.217	1.03061
1073	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]	PPA2	Subtracted	224.307	230.242	5.935
	ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9]	WBP2	Divided	216.901	210.485	1.03048
1074	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]	AIPL1	Subtracted	224.307	230.242	5.935
	coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606]	COPB2	Divided	174.387	179.697	1.03045
1075	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	AIP	Subtracted	224.307	230.242	5.935
	coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678]	COPG	Divided	174.387	179.697	1.03045

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.