MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2080 to 2129 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	Value Type	description	Filtered	red	green	network_comparison
260	Rooted	ribosomal protein l10-like protein. [refseq;acc:nm_080746]	0	22.3157	24.6207	1.10329
261	Measured	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]		1295.81	1463.55	1.12945
		signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	1	4247.36	5192.61	1.22255
	Ranked	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	0	12448.9	11393.9	1.09259
		heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	1	219.421	196.978	1.11394
	Squared	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	0	135280	170628	1.2613
		pyruvate carboxylase, mitochondrial precursor (ec 6.4.1.1) (pyruvic carboxylase) (pcb). [swissprot;acc:p11498]	1	48127.9	62245.6	1.29334
	Rooted	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	0	22.315	24.6198	1.10328
		ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	1	62.3337	70.0738	1.12417
262	Measured	adenylyl cyclase-associated protein 2 (cap 2). [swissprot;acc:p40123]	0	764.479	676.971	1.12926
		cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	1	24896.4	20431.7	1.21852
	Ranked	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]		219.421	196.978	1.11394
		sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	0	3464	3778	1.09065
	Squared	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]		2463.89	3102.4	1.25915
		neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	1	26157.6	20236.2	1.29261
	Rooted	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	0	26.0693	28.761	1.10325
		polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	1	59.4073	66.7002	1.12276
263	Measured	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	0	1843	1633	1.1286
		trs85 homolog. [swissprot;acc:q9y2l5]	1	24896.4	20431.7	1.21852
	Ranked	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	0	13573.3	14801.2	1.09046
		heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	1	219.421	196.978	1.11394
	Squared	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]		26157.6	20236.2	1.29261
		ribosomal protein l10-like protein. [refseq;acc:nm_080746]	0	2463.98	3102.52	1.25915
	Rooted	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]		4.79583	4.3589	1.10024
		paxillin. [swissprot;acc:p49023]	1	59.4073	66.7002	1.12276
264	Measured	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]		4987.58	4094.57	1.2181
		sodium/potassium-transporting atpase alpha-2 chain precursor (ec 3.6.3.9) (sodium pump 2) (na+/k+ atpase 2). [swissprot;acc:p50993]	0	3336.48	2957.12	1.12829
	Ranked	arsenical pump-driving atpase (ec 3.6.3.16) (arsenite-translocating atpase) (arsenical resistance atpase) (arsenite-transporting atpase) (arsa) (asna-i). [swissprot;acc:o43681]		10037.1	10935.1	1.08947
		mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	1	219.421	196.978	1.11394
	Squared	60s ribosomal protein l12. [swissprot;acc:p30050]	0	3686.65	4639.46	1.25845
		adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	1	26157.6	20236.2	1.29261
	Rooted	transcription elongation factor a protein 1 (transcription elongation factor s-ii protein 1) (transcription elongation factor tfiis.o). [swissprot;acc:p23193]	0	11.0015	9.99917	1.10024
		wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	1	66.1122	74.1438	1.12148
265	Measured	60s ribosomal protein l9. [swissprot;acc:p32969]	0	1685.44	1894.01	1.12375
		wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	1	24806.9	20369.9	1.21782
	Ranked	glycogenin-2 (ec 2.4.1.186) (gn-2) (gn2). [swissprot;acc:o15488]	0	13653.8	14874	1.08937
		splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	1	225.217	202.459	1.11241
	Squared	60s ribosomal protein l12 like protein. [sptrembl;acc:o60886]	0	3687.69	4640.77	1.25845
		leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]	1	26157.6	20236.2	1.29261
	Rooted	40s ribosomal protein s29. [swissprot;acc:p30054]	0	26.1023	28.6733	1.0985
		u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	1	56.031	62.8281	1.12131
266	Measured	aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	0	1475.05	1312.91	1.1235
		cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	1	24806.9	20369.9	1.21782
	Ranked	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	0	13483.3	14685.4	1.08915
		transcriptional co-repressor sin3a; transcriptional regulator, sin3a (yeast). [refseq;acc:nm_015477]	1	241.07	267.88	1.11121
	Squared	dj999l4.1 (novel protein similar to ribosomal protein l12 (rpl12)). [sptrembl;acc:q9nq02]	0	3687.33	4640.32	1.25845
		fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]	1	26157.6	20236.2	1.29261
	Rooted	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]		66.1064	74.1074	1.12103
		transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	0	39.5626	36.099	1.09595
267	Measured	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	1	14021.4	11523	1.21682

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.