MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2075 to 2124 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1038	no value	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	Divided	186.741	181.041	1.03148
	ERC1	elks protein. [refseq;acc:nm_015064]	Subtracted	218.162	211.648	6.514
1039	DLD	dihydrolipoamide dehydrogenase, mitochondrial precursor (ec 1.8.1.4) (glycine cleavage system l protein). [swissprot;acc:p09622]	Divided	207.719	214.236	1.03137
	PLEKHF2	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	Subtracted	220.118	213.685	6.433
1040	CCT5	t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643]	Divided	163.24	168.359	1.03136
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	Subtracted	220.118	213.685	6.433
1041	HNRNPL	heterogeneous nuclear ribonucleoprotein l (hnrnp l). [swissprot;acc:p14866]	Divided	186.774	181.099	1.03134
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	Subtracted	220.118	213.685	6.433
1042	no value	estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]	Divided	186.799	181.127	1.03132
	WBP2	ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9]	Subtracted	216.901	210.485	6.416
1043	no value	nucleolar protein nop5 (nucleolar protein 5) (nop58) (hspc120). [swissprot;acc:q9y2x3]		239.219	232.837	6.382
	AGPAT3	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Divided	187.834	182.137	1.03128
1044	DYNLT3	t-complex associated-testis-expressed 1-like (protein 91/23). [swissprot;acc:p51808]		173.475	178.889	1.03121
	FHL5	activator of camp-responsive element modulator (crem) in testis; lim protein act. [refseq;acc:nm_020482]	Subtracted	269.157	275.531	6.374
1045	CBS	cystathionine beta-synthase (ec 4.2.1.22) (serine sulfhydrase) (beta-thionase). [swissprot;acc:p35520]		205.632	199.266	6.366
	FIP1L1	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	Divided	115.817	119.432	1.03121
1046	MRE11A	double-strand break repair protein mre11a (mre11 homolog 1). [swissprot;acc:p49959]		173.475	178.889
	RHOC	transforming protein rhoc (h9). [swissprot;acc:p08134]	Subtracted	205.632	199.266	6.366
1047	ESRRA	steroid hormone receptor err1 (estrogen-related receptor, alpha) (err-alpha) (estrogen receptor-like 1). [swissprot;acc:p11474]	Divided	187.022	181.391	1.03104
	TST	thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762]	Subtracted	205.632	199.266	6.366
1048	AGPAT4	1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Divided	187.96	182.308	1.031
	MPST	3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	Subtracted	205.632	199.266	6.366
1049	no value	adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741]	Divided	211.449	217.998	1.03097
	RHOA	transforming protein rhoa (h12). [swissprot;acc:p06749]	Subtracted	205.632	199.266	6.366
1050	BYSL	bystin. [swissprot;acc:q13895]		239.505	233.185	6.32
	HSD17B1	estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061]	Divided	211.449	217.998	1.03097
1051	no value	17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]
	ANXA11	annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	Subtracted	219.673	213.378	6.295
1052	KARS	lysyl-trna synthetase (ec 6.1.1.6) (lysine--trna ligase) (lysrs). [swissprot;acc:q15046]		220.291	226.584	6.293
	RDH8	retinol dehydrogenase 8 (all-trans); photoreceptor outer segment all-trans retinol dehydrogenase. [refseq;acc:nm_015725]	Divided	211.449	217.998	1.03097
1053	ANXA7	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	Subtracted	219.655	213.385	6.27
	PSMA5	proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066]	Divided	207.04	200.84	1.03087
1054	no value	60s ribosomal protein l21. [swissprot;acc:p46778]		223.958	217.263	1.03082
	PSMA5	proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066]	Subtracted	207.04	200.84	6.2
1055	ASNSD1	hcv ns3-transactivated protein 1. [refseq;acc:nm_019048]	Divided	219.01	212.468	1.03079
	NFU1	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	Subtracted	138.705	132.538	6.167
1056	no value	methyltransferase like 2. [refseq;acc:nm_018396]		147.211	153.371	6.16
	ATP6V1A	vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606]	Divided	219.01	212.468	1.03079
1057	ASNS	asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]
	DYNLT1	cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763]	Subtracted	147.211	153.371	6.16
1058	ATXN2L	ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245]	Divided	228.105	221.293	1.03078
	FZR1	fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	Subtracted	147.211	153.371	6.16
1059	no value	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	Divided	228.105	221.293	1.03078
	PCSK5	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]	Subtracted	147.211	153.371	6.16
1060	NLK	nemo-like kinase; likely ortholog of mouse nemo like kinase. [refseq;acc:nm_016231]	Divided	218.162	211.648	1.03078
	SEPT6	septin 6. [swissprot;acc:q14141]	Subtracted	126.604	120.463	6.141
1061	AP3M1	adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]		217.323	211.185	6.138
	ERC1	elks protein. [refseq;acc:nm_015064]	Divided	218.162	211.648	1.03078
1062	BRP44	brain protein 44. [swissprot;acc:o95563]	Subtracted	126.215	120.078	6.137
	ZNF174	zinc finger protein 174 (aw-1). [swissprot;acc:q15697]	Divided	269.963	278.239	1.03066

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.