MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2068 to 2117 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1034	s-adenosylmethionine synthetase alpha and beta forms (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-i/iii). [swissprot;acc:q00266]	Divided	6152.88	6732.12	1.09414
1035	beta-catenin (pro2286). [swissprot;acc:p35222]	Subtracted	5635.26	6166.09	530.83
	casein kinase i, delta isoform (ec 2.7.1.-) (cki-delta) (ckid). [swissprot;acc:p48730]	Divided	5054.73	5530.23	1.09407
1036	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]		6077.65	6649.22	1.09404
	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	Subtracted	5910.54	6440.58	530.04
1037	monoglyceride lipase; lysophospholipase-like. [refseq;acc:nm_007283]	Divided	6544.26	7159.43	1.094
	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]	Subtracted	5910.54	6440.58	530.04
1038	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	Divided	5417.95	5924.41	1.09348
	phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]	Subtracted	5910.54	6440.58	530.04
1039	myb-related protein b (b-myb). [swissprot;acc:p10244]	Divided	5418.92	5923.09	1.09304
	tubulin-specific chaperone c (tubulin-folding cofactor c) (cfc). [swissprot;acc:q15814]	Subtracted	5719.01	6248.6	529.59
1040	putative acyl-coa thioester hydrolase cgi-16 (ec 3.1.2.-). [swissprot;acc:q9y305]
	rna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1). [swissprot;acc:q14498]	Divided	5421.93	5926.08	1.09298
1041	dead-box protein. [refseq;acc:nm_018665]	Subtracted	5719.01	6248.6	529.59
	myb-related protein a (a-myb). [swissprot;acc:p10243]	Divided	5419.18	5922.84	1.09294
1042	histone h2b.c (h2b/c). [swissprot;acc:q99880]	Subtracted	3946.32	4475.47	529.15
	similar to lim domain only 7 (fragment). [sptrembl;acc:q8n6m2]	Divided	5887.52	6434.32	1.09287
1043	15 kda selenoprotein precursor. [swissprot;acc:o60613]		6344.41	6933.36	1.09283
	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	Subtracted	3946.32	4475.47	529.15
1044	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]
	mbd2 (methyl-cpg-binding protein)-interacting zinc finger protein. [refseq;acc:nm_015517]	Divided	4757.46	5198.91	1.09279
1045	histone h2b. [refseq;acc:nm_175055]	Subtracted	3946.32	4475.47	529.15
	immature colon carcinoma transcript 1 (digestion substraction 1) (ds- 1). [swissprot;acc:q14197]	Divided	5364.32	5862.09	1.09279
1046	histone h2b.s (h2b/s). [swissprot;acc:p57053]	Subtracted	3946.32	4475.47	529.15
	skeletal muscle tropomodulin (sk-tmod) (tropomodulin 4). [swissprot;acc:q9nzq9]	Divided	4757.46	5198.91	1.09279
1047	histone h2b.d (h2b/d). [swissprot;acc:q99877]	Subtracted	3946.32	4475.47	529.15
	ubiquitous tropomodulin (u-tmod) (tropomodulin 3). [swissprot;acc:q9nyl9]	Divided	4757.46	5198.91	1.09279
1048	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	Subtracted	3946.32	4475.47	529.15
	tropomodulin 1 (erythrocyte tropomodulin) (e-tmod). [swissprot;acc:p28289]	Divided	4757.46	5198.91	1.09279
1049	sorting nexin 9 (sh3 and px domain-containing protein 1) (sdp1 protein). [swissprot;acc:q9y5x1]
	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	Subtracted	3946.32	4475.47	529.15
1050	histone h2b.e (h2b/e). [swissprot;acc:q99879]
	neuronal tropomodulin (n-tmod) (tropomodulin 2). [swissprot;acc:q9nzr1]	Divided	4757.46	5198.91	1.09279
1051	homeobox protein dlx-2. [swissprot;acc:q07687]
	signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240]	Subtracted	5208.27	5737.17	528.9
1052	homeobox protein dlx-5. [swissprot;acc:p56178]	Divided	4757.46	5198.91	1.09279
	protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031]	Subtracted	6278.76	6807.51	528.75
1053	fetal brain protein 239 (239fb). [swissprot;acc:q15777]	Divided	4757.46	5198.91	1.09279
	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	Subtracted	5166.04	5694.55	528.51
1054	heat shock factor binding protein 1. [swissprot;acc:o75506]		5915.42	6443.77	528.35
	homeobox protein dlx-3. [swissprot;acc:o60479]	Divided	4757.46	5198.91	1.09279
1055	activated p21cdc42hs kinase. [refseq;acc:nm_005781]
	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	Subtracted	5167.15	5695.44	528.29
1056	mitogen-activated protein kinase kinase kinase 7 interacting protein 2 isoform 1; tak1-binding protein 2. [refseq;acc:nm_015093]	Divided	4757.46	5198.91	1.09279
	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Subtracted	6413.32	6941.48	528.16
1057	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]		5168.01	5696.12	528.11
	tata element modulatory factor (tmf). [swissprot;acc:p82094]	Divided	5412.23	5913.4	1.0926
1058	protein-tyrosine phosphatase, non-receptor type 2 (ec 3.1.3.48) (t- cell protein-tyrosine phosphatase) (tcptp). [swissprot;acc:p17706]	Subtracted	6275.86	6803.95	528.09
	scy1-like 1; telomerase regulation-associated protein; ht019 protein; telomerase regulation-associated protein; n-terminal kinase-like protein; teratoma-associated tyrosine kinase; n-terminal kinase-like. [refseq;acc:nm_020680]	Divided	5412.23	5913.4	1.0926
1059	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]	Subtracted	3853.64	4379.71	526.07

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.