MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Value Type	Hugo	description	Interaction Map	network_comparison	Filtered	red	green

Results: HTML CSV LaTeX

Showing element 2075 to 2124 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Value Type	Hugo	description	Interaction Map	network_comparison	red	green
260	Ranked	ANKRD7	ankyrin repeat domain protein 7 (testis-specific protein tsa806). [swissprot;acc:q92527]	Low confidence	1.04589	216.855	207.34
		HS3ST6	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	High confidence	1.11394	219.421	196.978
	Squared	CXXC6	leukemia-associated protein with a cxxc domain. [sptrembl;acc:q8nfu7]	Low confidence	1.09045	50448.8	46264.1
		HIP1R	huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146]	High confidence	1.29752	76296.4	58801.6
	Rooted	SCYE1	multisynthetase complex auxiliary component p43 [contains: endothelial-monocyte activating polypeptide ii (emap-ii) (small inducible cytokine subfamily e member 1)]. [swissprot;acc:q12904]		1.12417	59.0951	66.4332
		WDR92	calcineurin b subunit isoform 1 (protein phosphatase 2b regulatory subunit 1) (protein phosphatase 3 regulatory subunit b alpha isoform 1). [swissprot;acc:p06705]	Low confidence	1.05655	67.4201	71.2324
261	Measured	FDX1	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]		1.06133	8837.18	9379.17
		SRP9	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	High confidence	1.22255	4247.36	5192.61
	Ranked	ANKRD19	ba526d8.2 (novel protein similar to kiaa1074). [sptrembl;acc:q9h560]	Low confidence	1.04588	216.845	207.333
		HS3ST3A1	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	High confidence	1.11394	219.421	196.978
	Squared	PC	pyruvate carboxylase, mitochondrial precursor (ec 6.4.1.1) (pyruvic carboxylase) (pcb). [swissprot;acc:p11498]		1.29334	48127.9	62245.6
		PSD4	sec7 homolog; adp-ribosylation factor guanine nucleotide-exchange factor 6. [refseq;acc:nm_012455]	Low confidence	1.09045	50448.8	46264.1
	Rooted	PDSS1	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]		1.05631	67.7274	71.5408
		RRM2B	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	High confidence	1.12417	62.3337	70.0738
262	Measured	ARHGAP26	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]	Low confidence	1.06122	6440.08	6834.37
		CPSF4	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	High confidence	1.21852	24896.4	20431.7
	Ranked	ANKRD30A	breast cancer antigen ny-br-1. [refseq;acc:nm_052997]	Low confidence	1.04587	216.842	207.332
		HS3ST3B1	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	High confidence	1.11394	219.421	196.978
	Squared	ARIH1	ariadne-1 protein homolog (ari-1) (ubiquitin-conjugating enzyme e2- binding protein 1) (ubch7-binding protein) (ubcm4-interacting protein) (hhari) (h7-ap2) (hussy-27) (mop-6). [swissprot;acc:q9y4x5]	Low confidence	1.09005	56512.1	51843.6
		CHRNA7	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]	High confidence	1.29261	26157.6	20236.2
	Rooted	GALE	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	Low confidence	1.0562	70.6152	74.5839
		POLI	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	High confidence	1.12276	59.4073	66.7002
263	Measured	KIAA1012	trs85 homolog. [swissprot;acc:q9y2l5]		1.21852	24896.4	20431.7
		STT3A	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	Low confidence	1.06106	7424.14	7877.49
	Ranked	no value	sodium/hydrogen exchanger 6 (na(+)/h(+) exchanger 6) (nhe-6). [swissprot;acc:q92581]		1.0458	216.546	207.063
		HS3ST2	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	High confidence	1.11394	219.421	196.978
	Squared	ADCY6	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]		1.29261	26157.6	20236.2
		CEP70	p10-binding protein. [refseq;acc:nm_024491]	Low confidence	1.08986	52319.1	48005.3
	Rooted	BICD2	coiled-coil protein bicd2; homolog of drosophila bicaudal d. [refseq;acc:nm_015250]		1.05603	70.75	74.7143
		PXN	paxillin. [swissprot;acc:p49023]	High confidence	1.12276	59.4073	66.7002
264	Measured	COPS3	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]		1.2181	4987.58	4094.57
		DGKQ	diacylglycerol kinase, theta (ec 2.7.1.107) (diglyceride kinase) (dgk- theta) (dag kinase theta). [swissprot;acc:p52824]	Low confidence	1.06105	6396.44	6786.96
	Ranked	DCPS	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	High confidence	1.11394	219.421	196.978
		LEO1	senescence downregulated leo1-like. [refseq;acc:nm_138792]	Low confidence	1.0458	216.546	207.063
	Squared	ADCY5	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	High confidence	1.29261	26157.6	20236.2
		C16orf70	upf0183 protein. [swissprot;acc:q9bsu1]	Low confidence	1.08984	43982.2	40356.7
	Rooted	BICD1	bicaudal d homolog 1; bicaudal-d, drosophila, homolog of, 1. [refseq;acc:nm_001714]		1.05603	70.75	74.7143
		WAS	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	High confidence	1.12148	66.1122	74.1438
265	Measured	SYNJ2	synaptojanin 2 (ec 3.1.3.36) (synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2) (fragment). [swissprot;acc:o15056]	Low confidence	1.06098	8081.02	8573.8
		WDR33	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	High confidence	1.21782	24806.9	20369.9
	Ranked	SF3B1	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]		1.11241	225.217	202.459
		SLC9A7	solute carrier family 9, member 7; nonselective sodium potassium/proton exchanger; sodium/hydrogen exchanger 7. [refseq;acc:nm_032591]	Low confidence	1.0458	216.546	207.063
	Squared	KIF3A	kinesin-like protein kif3a (microtubule plus end-directed kinesin motor 3a). [swissprot;acc:q9y496]		1.0897	47740.4	43810.6
		LRRC15	leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]	High confidence	1.29261	26157.6	20236.2
	Rooted	LSM8	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]		1.12131	56.031	62.8281
		TFIP11	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	Low confidence	1.05603	70.75	74.7143
266	Measured	CPA1	carboxypeptidase a1 precursor (ec 3.4.17.1). [swissprot;acc:p15085]		1.06089	8817.03	9353.9
		CPSF1	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	High confidence	1.21782	24806.9	20369.9
	Ranked	SIN3A	transcriptional co-repressor sin3a; transcriptional regulator, sin3a (yeast). [refseq;acc:nm_015477]		1.11121	241.07	267.88
		WDR92	calcineurin b subunit isoform 1 (protein phosphatase 2b regulatory subunit 1) (protein phosphatase 3 regulatory subunit b alpha isoform 1). [swissprot;acc:p06705]	Low confidence	1.04563	214.887	205.509

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.