MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 208 to 257 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	red	green	network_comparison
104	TARDBP	Subtracted	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	256.228	298.438	42.21
105	GNB1	Divided	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	266.716	333.165	1.24914
	JUND	Subtracted	transcription factor jun-d. [swissprot;acc:p17535]	200.941	158.941	42
106	COQ7	Divided	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	252.329	202.004	1.24913
	NOSTRIN	Subtracted	nostrin. [refseq;acc:nm_052946]	209.299	249.187	39.888
107	HOMER1	Divided	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	252.309	201.998	1.24907
	SNF8	Subtracted	eap30 subunit of ell complex. [refseq;acc:nm_007241]	209.299	249.187	39.888
108	HOMER3	Divided	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	252.296	201.995	1.24902
	SLC39A6	Subtracted	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	209.299	249.187	39.888
109	GAD2		glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]
	GNB4	Divided	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	266.933	333.281	1.24856
110	DTX2		deltex 2. [refseq;acc:nm_020892]	333.144	267.393	1.2459
	NAPG	Subtracted	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	209.299	249.187	39.888
111	DTX1	Divided	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	332.925	267.274	1.24563
	GAD1	Subtracted	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	209.299	249.187	39.888
112	PBK	Divided	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	332.874	267.246	1.24557
	POLE4	Subtracted	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	275.754	235.908	39.846
113	KHDRBS3	Divided	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	332.874	267.246	1.24557
	PPP2CA	Subtracted	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	194.372	234.204	39.832
114	B9D1		b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	229.818	267.265	37.447
	KHDRBS1	Divided	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	332.874	267.246	1.24557
115	HAT1	Subtracted	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	277.546	240.461	37.085
	KHDRBS2	Divided	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	332.874	267.246	1.24557
116	GNB3		guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	268.565	334.483	1.24545
	HMG20B	Subtracted	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	208.52	171.595	36.925
117	HMG20A		high-mobility group 20a. [refseq;acc:nm_018200]	208.588	171.778	36.81
	NEURL	Divided	neuralized-like. [refseq;acc:nm_004210]	332.326	266.948	1.24491
118	NDUFA12		nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	284.753	228.934	1.24382
	OSR1	Subtracted	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	274.027	237.79	36.237
119	ADIPOR2		adiponectin receptor 2. [refseq;acc:nm_024551]	281.582	246.371	35.211
	NDUFS4	Divided	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	318.982	259.004	1.23157
120	KCND2		potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	269.278	327.709	1.21699
	TIA1	Subtracted	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	227.199	192.715	34.484
121	CTH	Divided	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	269.254	327.655	1.2169
	TIAL1	Subtracted	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	227.202	192.823	34.379
122	COPS3		cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	199.949	234.187	34.238
	KCND3	Divided	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	269.248	327.642	1.21688
123	KCND1		potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	269.23	327.601	1.21681
	SNRPD1	Subtracted	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	227.032	193.056	33.976
124	HMG20B	Divided	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	208.52	171.595	1.21519
	PSEN2	Subtracted	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	285.684	252.234	33.45
125	HMG20A	Divided	high-mobility group 20a. [refseq;acc:nm_018200]	208.588	171.778	1.21429
	SKP1A	Subtracted	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	285.684	252.234	33.45
126	FBXW7		f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]
	STAMBPL1	Divided	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	94	114	1.21277
127	CHMP2A		putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]
	CUL2	Subtracted	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	285.684	252.234	33.45
128	PSEN1		presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]
	STAMBP	Divided	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	94	114	1.21277
129	CUL1	Subtracted	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	285.684	252.234	33.45

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.