MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 208 to 257 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	875	PRKAA2	High confidence	212.002	203.954	1.03946
	1681		Low confidence	200.826	196.771	1.02061
5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	874	PRKAG1	High confidence	212.002	203.954	1.03946
	2295		Low confidence	196.86	193.236	1.01875
5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	880	PRKAG2	High confidence	212.002	203.954	1.03946
	2304		Low confidence	196.768	193.154	1.01871
5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	878	PRKAG3	High confidence	212.002	203.954	1.03946
	2294		Low confidence	196.869	193.244	1.01876
5'-methylthioadenosine phosphorylase (ec 2.4.2.28) (mta phosphorylase) (mtapase). [swissprot;acc:q13126]	1769	MTAP	High confidence	223.016	225.734	1.01219
	3870		Low confidence	199.433	196.894	1.0129
5'-nucleotidase precursor (ec 3.1.3.5) (ecto-5'-nucleotidase) (5'-nt) (cd73 antigen). [swissprot;acc:p21589]	4657	NT5E		204.851	203.584	1.00622
5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]	841	TYRP1		206.243	201.027	1.02595
	1021		High confidence	221.278	214.409	1.03204
5-aminolevulinic acid synthase, erythroid-specific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-e). [swissprot;acc:p22557]	2491	ALAS2		194.527	195.08	1.00284
	2505		Low confidence	198.676	195.131	1.01817
5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-h). [swissprot;acc:p13196]	2496	ALAS1	High confidence	194.527	195.08	1.00284
	2520		Low confidence	198.651	195.109	1.01815
5-formyltetrahydrofolate cyclo-ligase (ec 6.3.3.2) (5,10-methenyl- tetrahydrofolate synthetase) (methenyl-thf synthetase) (mthfs). [swissprot;acc:p49914]	2263	MTHFS		196.131	192.502	1.01885
	2754		High confidence	210.638	210.642	1.00002
5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707]	1921	MTR		221.607	219.386	1.01012
	3629		Low confidence	192.426	189.733	1.01419
5-oxoprolinase (ec 3.5.2.9) (5-oxo-l-prolinase) (pyroglutamase) (5-opase) (fragment). [swissprot;acc:o14841]	3199	OPLAH		195.682	192.595	1.01603
54 kda nuclear rna- and dna-binding protein (p54(nrb)) (p54nrb) (55 kda nuclear protein) (nmt55) (non-pou domain-containing octamer- binding protein) (dna-binding p52/p100 complex, 52 kda subunit). [swissprot;acc:q15233]	1292	NONO		200.544	196.152	1.02239
	2532		High confidence	190.405	190.812	1.00214
5t4 oncofetal trophoblast glycoprotein; 5t4-antigen. [refseq;acc:nm_006670]	3485	TPBG	Low confidence	202.475	199.484	1.01499
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6pf-2-k/fru- 2,6-p2ase liver isozyme) [includes: 6-phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:p16118]	3865	PFKFB1		194.792	197.306	1.01291
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6pf-2-k/fru- 2,6-p2ase heart-type isozyme) (pfk-2/fbpase-2) [includes: 6- phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:o60825]	3867	PFKFB2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6pf-2-k/fru- 2,6-p2ase brain/placenta-type isozyme) (ipfk-2) [includes: 6- phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:q16875]	3864	PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6pf-2-k/fru- 2,6-p2ase testis-type isozyme) [includes: 6-phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:q16877]	3868	PFKFB4
6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858]	1822	PFKL	High confidence	240.32	243.085	1.01151
	2739		Low confidence	200.929	197.479	1.01747
6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [swissprot;acc:p08237]	1830	PFKM	High confidence	240.32	243.069	1.01144
	2769		Low confidence	200.94	197.499	1.01742
6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [swissprot;acc:q01813]	1883	PFKP	High confidence	240.317	242.881	1.01067
	2706		Low confidence	200.868	197.403	1.01755
6-phosphogluconate dehydrogenase, decarboxylating (ec 1.1.1.44). [swissprot;acc:p52209]	1923	PGD		201.484	197.59	1.01971
	2274		High confidence	213.642	214.801	1.00542
6-phosphogluconolactonase (ec 3.1.1.31) (6pgl). [swissprot;acc:o95336]	1584	PGLS		216.891	220.432	1.01633
	2807		Low confidence	200.157	196.756	1.01729
6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [swissprot;acc:q03393]	2904	PTS	High confidence	0.00001	0.00001	1
	4128		Low confidence	198.355	196.271	1.01062
60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [swissprot;acc:p10809]	2588	HSPD1	High confidence	222.305	222.64	1.00151
	2591		Low confidence	199.427	195.908	1.01796
60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]	826	HTATIP	High confidence	223.186	213.912	1.04335
	3722		Low confidence	200.338	197.651	1.01359
60s acidic ribosomal protein p0 (l10e). [swissprot;acc:p05388]	1092	RPLP0	High confidence	226.203	232.855	1.02941
	3897		Low confidence	202.202	199.673	1.01267
60s acidic ribosomal protein p1. [swissprot;acc:p05386]	898	no value	High confidence	229.171	238.048	1.03874
	4994		Low confidence	203.12	203.189	1.00034
60s acidic ribosomal protein p2. [swissprot;acc:p05387]	720	RPLP2	High confidence	231.92	244.435	1.05396

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.