MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 208 to 257 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	red	network_comparison	green
208	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	SKP1A	285.684	1.13261	252.234
209	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	FBXW7
210	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	CUL2
211	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	PSEN1
212	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	CUL1
213	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	PLDN	210.693	1.127	186.95
214	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	LASS2	191.644	1.12605	170.192
215	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	no value	112	1.125	126
216	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	MYH4
217	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	MYH8
218	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	MYH2
219	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	MYH3
220	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	MYH1
221	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	no value
222	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	MYH7B
223	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	MYH13
224	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	SLC15A2	185.969	1.12285	165.623
225	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	SNRPD2	226.471	1.12243	201.769
226	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	COMP	239.991	1.12187	269.238
227	thrombospondin 3 precursor. [swissprot;acc:p49746]	THBS3	239.99	1.12186	269.234
228	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	SH2D3C	226.411	1.12036	202.088
229	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	BCAR3	226.401	1.12028	202.094
230	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]	CSRP1	239.35	1.11934	267.915
231	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]	SHCBP1	239.336	1.11927	267.881
232	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	CSRP2		1.11926	267.879
233	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	CSRP3	239.32	1.11918	267.842
234	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	CHRAC1	287.41	1.11905	256.835
235	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	PAH	227.357	1.11785	254.15
236	pp3111 protein. [refseq;acc:nm_022156]	DUS1L
237	syntaxin 18. [swissprot;acc:q9p2w9]	STX18
238	rd protein. [swissprot;acc:p18615]	no value
239	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	GSTO1
240	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	AIG1
241	atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539]	ATP5F1
242	j domain containing protein 1. [swissprot;acc:q9ukb3]	DNAJC12
243	sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8]	SNX13
244	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	GSTO2
245	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	SNRPD3	226.109	1.11751	202.333
246	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	EIF4G3	237.312	1.11748	212.363
247	rna-binding protein. [refseq;acc:nm_019027]	no value	237.302	1.11719	212.41
248	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]
249	ns1-associated protein 1. [refseq;acc:nm_006372]	SYNCRIP
250	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	HNRNPR
251	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	SLC15A1	186.172	1.11707	166.661
252	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	EIF4G1	237.292	1.11689	212.457
253	mad protein (max dimerizer). [swissprot;acc:q05195]	MXD1	228	1.11583	204.333
254	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	STT3B	200.691	1.11569	179.88
255	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	STT3A
256	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	MXI1	227.999		204.357
257	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	DDOST	200.691		179.88

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.