MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 208 to 257 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Interaction Map	red	network_comparison	green
3 beta-hydroxy-delta 5-c27-steroid oxidoreductase. [refseq;acc:nm_025193]	1737	HSD3B7	Subtracted	Low confidence	197.872	4.006	193.866
	3147		Divided	High confidence	0.00001	1	0.00001
			Subtracted		0	0	0
3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	1663	no value	Divided	Low confidence	197.872	1.02066	193.866
	1733		Subtracted			4.006
	2756		Divided	High confidence	0.00001	1	0.00001
			Subtracted		0	0	0
3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type i (3beta-hsd i) (trophoblast antigen fdo161g) [includes: 3-beta-hydroxy- delta(5)-steroid dehydrogenase (ec 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (progesterone reductase); steroid delta- isomerase (ec 5.3.3.1) (delta-5-3-ketosteroid isomerase)]. [swissprot;acc:p14060]	1665		Divided	Low confidence	197.872	1.02066	193.866
	1735		Subtracted			4.006
	2802		Divided	High confidence	0.00001	1	0.00001
			Subtracted		0	0	0
3'(2'), 5'-bisphosphate nucleotidase 1; bisphosphate 3'-nucleotidase; bpntase; pap-inositol-1,4-phosphatase. [refseq;acc:nm_006085]	164	BPNT1		Low confidence	209.954	11.653	221.607
	178		Divided			1.0555
3'-5' rna exonuclease; polynucleotide phosphorylase-like. [refseq;acc:nm_033109]	1268	PNPT1	Subtracted		206.13	4.434	201.696
	1373		Divided			1.02198
3-hydroxy-3-methylglutaryl-coenzyme a reductase (ec 1.1.1.34) (hmg-coa reductase). [swissprot;acc:p04035]	2303	HMGCR		High confidence	191.567	1.00509	192.542
	2333		Subtracted			0.975
	3261		Divided	Low confidence	199.744	1.01577	196.642
	3322		Subtracted			3.102
3-hydroxyacyl-coa dehydrogenase type ii (ec 1.1.1.35) (type ii hadh) (endoplasmic reticulum-associated amyloid beta-peptide binding protein) (short-chain type dehydrogenase/reductase xh98g2). [swissprot;acc:q99714]	3180	HSD17B10	Divided	High confidence	0.00001	1	0.00001
			Subtracted		0	0	0
	4083			Low confidence	202.282	2.189	200.093
	4091		Divided			1.01094
3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952]	1250	HAAO			180.665	1.02263	176.667
	1746		Subtracted			3.998
	2189		Divided	High confidence	209.54	1.00662	208.162
	2201		Subtracted			1.378
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	855	no value		Low confidence	203.354	5.07	198.284
	879		Divided			1.02557
	1852			High confidence	196.008	1.01095	198.154
	1914		Subtracted			2.146
3-ketoacyl-coa thiolase, peroxisomal precursor (ec 2.3.1.16) (beta- ketothiolase) (acetyl-coa acyltransferase) (peroxisomal 3-oxoacyl- coa thiolase). [swissprot;acc:p09110]	2300	ACAA1	Divided		191.563	1.00511	192.541
	2331		Subtracted			0.978
	2649		Divided	Low confidence	195.904	1.01776	192.486
	2813		Subtracted			3.418
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	1025	MPST	Divided	High confidence	205.632	1.03195	199.266
	1048		Subtracted			6.366
	2252		Divided	Low confidence	196.562	1.01888	192.92
	2394		Subtracted			3.642
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	914	SRD5A1			204.147	4.951	199.196
	949		Divided			1.02485
	1040		Subtracted	High confidence	220.118	6.433	213.685
	1083		Divided			1.03011
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	915	SRD5A2	Subtracted	Low confidence	204.147	4.951	199.196
	950		Divided			1.02485
	1041		Subtracted	High confidence	220.118	6.433	213.685
	1084		Divided			1.03011
3-oxo-5-beta-steroid 4-dehydrogenase (ec 1.3.99.6) (delta(4)-3- ketosteroid 5-beta-reductase) (aldo-keto reductase family 1 member d1). [swissprot;acc:p51857]	1896	AKR1D1	Subtracted	Low confidence	201.286	3.902	197.384
	1902		Divided			1.01977
3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	739	PDPK1	Subtracted	High confidence	272.878	10.594	283.472

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.