MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 2051 to 2100 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	711	FTHL17	Subtracted	220.431	209.123	11.308
	712		Divided			1.05407
ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	708	FTL	Subtracted	220.438	209.118	11.32
	709		Divided			1.05413
ferrochelatase, mitochondrial precursor (ec 4.99.1.1) (protoheme ferro-lyase) (heme synthetase). [swissprot;acc:p22830]	3185	FECH		0.00001	0.00001	1
			Subtracted	0	0	0
fetal brain protein 239 (239fb). [swissprot;acc:q15777]	2315	MPPED2		229.258	230.294	1.036
	2339		Divided			1.00452
fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]	677	FBL	Subtracted	245.246	233.483	11.763
	748		Divided			1.05038
fibrillin 1 precursor. [swissprot;acc:p35555]	2844	FBN1		0.00001	0.00001	1
			Subtracted	0	0	0
fibrillin 2 precursor. [swissprot;acc:p35556]	2955	FBN2	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
fibrillin 3. [refseq;acc:nm_032447]	2939	FBN3	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
fibulin-1 precursor. [swissprot;acc:p23142]	2349	FBLN1	Divided	192.348	191.503	1.00441
	2381		Subtracted			0.845
fibulin-2 precursor. [swissprot;acc:p98095]	2245	FBLN2	Divided	191.618	190.448	1.00614
	2264		Subtracted			1.17
ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	25	FCN2		322	253	69
	40		Divided			1.27273
fidgetin-like 1. [refseq;acc:nm_022116]	2069	FIGNL1	Subtracted	215.511	213.814	1.697
	2078		Divided			1.00794
filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	153	no value	Subtracted	226.582	198.444	28.138
	191		Divided			1.14179
filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	148	FLNB	Subtracted			28.138
	186		Divided			1.14179
fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	1045	FIP1L1		115.817	119.432	1.03121
	1558		Subtracted			3.615
fk506-binding protein 1a (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (12 kda fkbp) (fkbp-12) (immunophilin fkbp12). [swissprot;acc:p20071]	1325	FKBP1A		216.542	211.908	4.634
	1375		Divided			1.02187
flap endonuclease-1 (ec 3.-.-.-) (maturation factor 1) (mf1). [swissprot;acc:p39748]	2831	FEN1		0.00001	0.00001	1
			Subtracted	0	0	0
flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	541	MICAL2	Divided	222.156	208.201	1.06703
	549		Subtracted			13.955
flotillin-1. [swissprot;acc:o75955]	1257	FLOT1		218.368	213.22	5.148
	1289		Divided			1.02414
folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	1132	FPGS	Subtracted	225.906	231.524	5.618
	1224		Divided			1.02487
forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	135	FOXP4	Subtracted	263.215	231.407	31.808
	196		Divided			1.13745
forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	619	FOXG1		214.256	202.139	1.05994
	652		Subtracted			12.117
forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	136	FOXP1		263.215	231.407	31.808
	197		Divided			1.13745
forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	137	FOXP3	Subtracted	263.191	231.394	31.797
	198		Divided			1.13741
formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	133	no value	Subtracted	226.887	194.72	32.167
	178		Divided			1.1652

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.