MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2030 to 2079 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
508	APP	amyloid beta a4 protein precursor (app) (abpp) (alzheimer's disease amyloid protein) (cerebral vascular amyloid peptide) (cvap) (protease nexin-ii) (pn-ii) (appi) (prea4) [contains: soluble app-alpha (s-app- alpha); soluble app-beta (s-app-beta); c99; beta-amyloid protein 42 (beta-app42); beta-amyloid protein 40 (beta-app40); c83; p3(42); p3(40); gamma-ctf(59) (gamma-secretase c-terminal fragment 59) (amyloid intracellular domain 59) (aid(59)); gamma-ctf(57) (gamma- secretase c-terminal fragment 57) (amyloid intracellular domain 57) (aid(57)); gamma-ctf(50) (gamma-secretase c-terminal fragment 50) (amyloid intracellular domain 50) (aid(50)); c31]. [swissprot;acc:p05067]	Divided	Low confidence	205.157	198.715	1.03242
	CPA3	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]		High confidence	177.698	190.24	1.07058
	LSM8	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	Subtracted		228.255	213.422	14.833
509	APLP1	amyloid-like protein 1 precursor (aplp) (aplp-1) [contains: c30]. [swissprot;acc:p51693]		Low confidence	205.157	198.715	6.442
	CPA6	carboxypeptidase b precursor. [refseq;acc:nm_020361]	Divided	High confidence	177.698	190.239	1.07057
	EXOSC3	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	Subtracted		215.237	230.07	14.833
	TTYH2	tweety homolog 2. [refseq;acc:nm_032646]	Divided	Low confidence	205.157	198.715	1.03242
510	no value	myoglobin. [swissprot;acc:p02144]	Subtracted				6.442
	CPB2	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	Divided	High confidence	177.699	190.24	1.07057
	EXOSC5	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	Subtracted		215.237	230.07	14.833
	HBZ	hemoglobin zeta chain (hbaz). [swissprot;acc:p02008]	Divided	Low confidence	205.157	198.715	1.03242
511	no value	alpha 2 globin. [refseq;acc:nm_000517]
	HBQ1	hemoglobin theta-1 chain. [swissprot;acc:p09105]	Subtracted				6.442
	NOL1	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	Divided	High confidence	250.053	233.725	1.06986
	SLC35D2	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	Subtracted		214.754	229.565	14.811
512	APLP1	amyloid-like protein 1 precursor (aplp) (aplp-1) [contains: c30]. [swissprot;acc:p51693]	Divided	Low confidence	205.157	198.715	1.03242
	BOP1	block of proliferation 1. [swissprot;acc:q14137]		High confidence	250.794	234.433	1.06979
	DHX15	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	Subtracted		229.803	215.301	14.502
	TTYH1	tweety homolog 1; tweety homolog. [refseq;acc:nm_020659]		Low confidence	205.156	198.715	6.441
513	no value	myoglobin. [swissprot;acc:p02144]	Divided		205.157		1.03242
	CYGB	cytoglobin (histoglobin) (hgb) (stellate cell activation-associated protein). [swissprot;acc:q8wwm9]	Subtracted		205.156		6.441
	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Divided	High confidence	218.596	204.344	1.06975
	LSM6	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	Subtracted		227.483	212.994	14.489
514	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	Divided		218.613	204.382	1.06963
	FOXO3	forkhead box protein o3a (forkhead in rhabdomyosarcoma-like 1) (af6q21 protein). [swissprot;acc:o43524]	Subtracted	Low confidence	205.156	198.715	6.441
	HBQ1	hemoglobin theta-1 chain. [swissprot;acc:p09105]	Divided		205.157		1.03242
	PLRG1	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	Subtracted	High confidence	222.893	208.523	14.37
515	AKT1	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]			248.463	234.095	14.368
	APLP2	amyloid-like protein 2 precursor (amyloid protein homolog) (apph) (cdei-box binding protein) (cdebp). [swissprot;acc:q06481]		Low confidence	205.156	198.715	6.441
	PES1	pescadillo homolog 1. [swissprot;acc:o00541]	Divided	High confidence	251.297	234.941	1.06962
	TTYH1	tweety homolog 1; tweety homolog. [refseq;acc:nm_020659]		Low confidence	205.156	198.715	1.03241
516	AKT3	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	Subtracted	High confidence	248.463	234.095	14.368
	CYGB	cytoglobin (histoglobin) (hgb) (stellate cell activation-associated protein). [swissprot;acc:q8wwm9]	Divided	Low confidence	205.156	198.715	1.03241
	LSM8	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]		High confidence	228.255	213.422	1.0695
	SORBS2	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	Subtracted	Low confidence	205.451	199.011	6.44
517	AKT2	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]		High confidence	248.463	234.095	14.368
	FOXO3	forkhead box protein o3a (forkhead in rhabdomyosarcoma-like 1) (af6q21 protein). [swissprot;acc:o43524]	Divided	Low confidence	205.156	198.715	1.03241
	MTX2	metaxin 2. [swissprot;acc:o75431]		High confidence	219.537	234.793	1.06949
	POLI	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	Subtracted	Low confidence	203.167	196.732	6.435
518	APLP2	amyloid-like protein 2 precursor (amyloid protein homolog) (apph) (cdei-box binding protein) (cdebp). [swissprot;acc:q06481]	Divided		205.156	198.715	1.03241
	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Subtracted	High confidence	218.596	204.344	14.252
	GNL3	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	Divided		250.858	234.563	1.06947
	MEGF11	megf11 protein. [refseq;acc:nm_032445]	Subtracted	Low confidence	207.951	201.517	6.434
519	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]		High confidence	218.613	204.382	14.231
	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Divided		218.702	204.582	1.06902
	SAMSN1	sam-domain protein samsn-1 (sam domain, sh3 domain and nuclear localisation signals protein 1). [swissprot;acc:q9nsi8]		Low confidence	204.278	210.893	1.03238
	SLC2A11	solute carrier family 2, facilitated glucose transporter, member 11 (glucose transporter type 11) (glucose transporter type 10). [swissprot;acc:q9byw1]	Subtracted		205.551	199.117	6.434
520	GYG1	glycogenin-1 (ec 2.4.1.186). [swissprot;acc:p46976]	Divided		200.014	193.745	1.03236
	MEGF10	megf10 protein. [refseq;acc:nm_032446]	Subtracted		207.949	201.517	6.432
	PRPF19	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]		High confidence	223.356	209.149	14.207

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.