MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2008 to 2057 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	network_comparison	green
502	TLX1	t-cell leukemia homeobox protein 1 (homeobox protein hox-11) (tcl-3 proto-oncogene). [swissprot;acc:p31314]	Subtracted	High confidence	237.28	15.212	252.492
503	FOXO4	putative fork head domain transcription factor afx1 (forkhead box protein o4). [swissprot;acc:p98177]		Low confidence	205.157	6.442	198.715
	HECTD1	hect domain containing protein 1 (fragment). [swissprot;acc:q9ult8]		High confidence	237.28	15.212	252.492
	RGN	senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]	Divided		238.704	1.07112	255.68
	USP22	ubiquitin carboxyl-terminal hydrolase 22 (ec 3.1.2.15) (ubiquitin thiolesterase 22) (ubiquitin-specific processing protease 22) (deubiquitinating enzyme 22) (fragment). [swissprot;acc:q9upt9]		Low confidence	207.407	1.03255	200.869
504	no value	hemoglobin gamma-a and gamma-g chains. [swissprot;acc:p02096]	Subtracted		205.157	6.442	198.715
	BARX2	homeobox protein barh-like 2. [swissprot;acc:q9umq3]		High confidence	237.28	15.212	252.492
	OPHN1	oligophrenin 1. [swissprot;acc:o60890]	Divided		238.704	1.07112	255.68
	RNF113A	zinc finger protein 183. [swissprot;acc:o15541]		Low confidence	205.192	1.03254	198.726
505	APP	amyloid beta a4 protein precursor (app) (abpp) (alzheimer's disease amyloid protein) (cerebral vascular amyloid peptide) (cvap) (protease nexin-ii) (pn-ii) (appi) (prea4) [contains: soluble app-alpha (s-app- alpha); soluble app-beta (s-app-beta); c99; beta-amyloid protein 42 (beta-app42); beta-amyloid protein 40 (beta-app40); c83; p3(42); p3(40); gamma-ctf(59) (gamma-secretase c-terminal fragment 59) (amyloid intracellular domain 59) (aid(59)); gamma-ctf(57) (gamma- secretase c-terminal fragment 57) (amyloid intracellular domain 57) (aid(57)); gamma-ctf(50) (gamma-secretase c-terminal fragment 50) (amyloid intracellular domain 50) (aid(50)); c31]. [swissprot;acc:p05067]	Subtracted		205.157	6.442	198.715
	NOC3L	ad24 protein. [refseq;acc:nm_022451]	Divided	High confidence	251.334	1.071	234.672
	PCNA	proliferating cell nuclear antigen (pcna) (cyclin). [swissprot;acc:p12004]		Low confidence	207.84	1.0325	201.297
	ZNF593	zinc finger protein t86. [swissprot;acc:o00488]	Subtracted	High confidence	246.805	15.009	231.796
506	EXOSC4	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]			215.237	14.833	230.07
	FOXO4	putative fork head domain transcription factor afx1 (forkhead box protein o4). [swissprot;acc:p98177]	Divided	Low confidence	205.157	1.03242	198.715
	ING1	inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537]		High confidence	224.535	1.071	240.476
	TTYH2	tweety homolog 2. [refseq;acc:nm_032646]	Subtracted	Low confidence	205.157	6.442	198.715
507	no value	hemoglobin gamma-a and gamma-g chains. [swissprot;acc:p02096]	Divided			1.03242
	EXOSC2	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	Subtracted	High confidence	215.237	14.833	230.07
	HBZ	hemoglobin zeta chain (hbaz). [swissprot;acc:p02008]		Low confidence	205.157	6.442	198.715
	WDR12	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	Divided	High confidence	251.299	1.07059	234.729
508	no value	alpha 2 globin. [refseq;acc:nm_000517]	Subtracted	Low confidence	205.157	6.442	198.715
	APP	amyloid beta a4 protein precursor (app) (abpp) (alzheimer's disease amyloid protein) (cerebral vascular amyloid peptide) (cvap) (protease nexin-ii) (pn-ii) (appi) (prea4) [contains: soluble app-alpha (s-app- alpha); soluble app-beta (s-app-beta); c99; beta-amyloid protein 42 (beta-app42); beta-amyloid protein 40 (beta-app40); c83; p3(42); p3(40); gamma-ctf(59) (gamma-secretase c-terminal fragment 59) (amyloid intracellular domain 59) (aid(59)); gamma-ctf(57) (gamma- secretase c-terminal fragment 57) (amyloid intracellular domain 57) (aid(57)); gamma-ctf(50) (gamma-secretase c-terminal fragment 50) (amyloid intracellular domain 50) (aid(50)); c31]. [swissprot;acc:p05067]	Divided			1.03242
	CPA3	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]		High confidence	177.698	1.07058	190.24
	LSM8	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	Subtracted		228.255	14.833	213.422
509	APLP1	amyloid-like protein 1 precursor (aplp) (aplp-1) [contains: c30]. [swissprot;acc:p51693]		Low confidence	205.157	6.442	198.715
	CPA6	carboxypeptidase b precursor. [refseq;acc:nm_020361]	Divided	High confidence	177.698	1.07057	190.239
	EXOSC3	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	Subtracted		215.237	14.833	230.07
	TTYH2	tweety homolog 2. [refseq;acc:nm_032646]	Divided	Low confidence	205.157	1.03242	198.715
510	no value	myoglobin. [swissprot;acc:p02144]	Subtracted			6.442
	CPB2	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	Divided	High confidence	177.699	1.07057	190.24
	EXOSC5	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	Subtracted		215.237	14.833	230.07
	HBZ	hemoglobin zeta chain (hbaz). [swissprot;acc:p02008]	Divided	Low confidence	205.157	1.03242	198.715
511	no value	alpha 2 globin. [refseq;acc:nm_000517]
	HBQ1	hemoglobin theta-1 chain. [swissprot;acc:p09105]	Subtracted			6.442
	NOL1	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	Divided	High confidence	250.053	1.06986	233.725
	SLC35D2	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	Subtracted		214.754	14.811	229.565
512	APLP1	amyloid-like protein 1 precursor (aplp) (aplp-1) [contains: c30]. [swissprot;acc:p51693]	Divided	Low confidence	205.157	1.03242	198.715
	BOP1	block of proliferation 1. [swissprot;acc:q14137]		High confidence	250.794	1.06979	234.433
	DHX15	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	Subtracted		229.803	14.502	215.301
	TTYH1	tweety homolog 1; tweety homolog. [refseq;acc:nm_020659]		Low confidence	205.156	6.441	198.715
513	no value	myoglobin. [swissprot;acc:p02144]	Divided		205.157	1.03242
	CYGB	cytoglobin (histoglobin) (hgb) (stellate cell activation-associated protein). [swissprot;acc:q8wwm9]	Subtracted		205.156	6.441
	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Divided	High confidence	218.596	1.06975	204.344
	LSM6	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	Subtracted		227.483	14.489	212.994
514	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	Divided		218.613	1.06963	204.382
	FOXO3	forkhead box protein o3a (forkhead in rhabdomyosarcoma-like 1) (af6q21 protein). [swissprot;acc:o43524]	Subtracted	Low confidence	205.156	6.441	198.715
	HBQ1	hemoglobin theta-1 chain. [swissprot;acc:p09105]	Divided		205.157	1.03242
	PLRG1	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	Subtracted	High confidence	222.893	14.37	208.523
515	AKT1	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]			248.463	14.368	234.095

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.