MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Network Comparison Type	Gene	description	Hugo	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2008 to 2057 of 2061 in total

Network Comparison Type  : Subtracted
Interaction Map  : Low confidence
Filtered  : 1
network_comparison  : 0

Rank	description	Hugo	Value Type	red	green
5048	double-stranded rna-binding zinc finger protein jaz. [refseq;acc:nm_012279]	ZNF346	Rooted	0	0
	mitogen-activated protein kinase kinase 1 interacting protein 1 (mek binding partner 1) (mp1) (pro2783). [swissprot;acc:q9uha4]	MAP2K1IP1	Ranked
5049	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	PSCD1		177.3	177.3
	mitogen-activated protein kinase kinase 1 interacting protein 1 (mek binding partner 1) (mp1) (pro2783). [swissprot;acc:q9uha4]	MAP2K1IP1	Measured	0	0
			Squared
			Rooted
5050	lipin 2. [swissprot;acc:q92539]	LPIN2	Measured
			Ranked
			Squared
			Rooted
5051	sam domain and hd domain-containing protein 1 (dendritic cell-derived ifng-induced protein) (dcip) (monocyte protein 5) (mop-5). [swissprot;acc:q9y3z3]	SAMHD1	Measured
			Ranked
			Squared
			Rooted
5052	tubulin tyrosine ligase-like protein 1. [swissprot;acc:o95922]	TTLL1	Measured
			Ranked
			Squared
			Rooted
5053	gamma-glutamyltransferase. [sptrembl;acc:q14390]	GGTL4	Measured
			Ranked
			Squared
			Rooted
5054	gamma-glutamyltranspeptidase 1 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 1) (cd224 antigen). [swissprot;acc:p19440]	GGT1	Measured
			Ranked
			Squared
			Rooted
5055	gamma-glutamyltranspeptidase 5 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 5) (ggt-rel). [swissprot;acc:p36269]	GGTLA1	Measured
			Ranked
			Squared
			Rooted
5056	putative nadh oxidoreductase complex i subunit homolog. [sptrembl;acc:q96q80]	DERL3	Measured
			Ranked
			Squared
			Rooted
5057	leucine rich repeat (in flii) interacting protein 2. [refseq;acc:nm_006309]	LRRFIP2	Measured
			Ranked
			Squared
			Rooted
5058	carcinoma related gene. [refseq;acc:nm_016041]	DERL2	Measured
			Ranked
			Squared
			Rooted
5059	core-binding factor, beta subunit (cbf-beta) (polyomavirus enhancer binding protein 2 beta subunit) (pebp2-beta) (pea2-beta) (sl3-3 enhancer factor 1 beta subunit) (sl3/akv core-binding factor beta subunit). [swissprot;acc:q13951]	CBFB	Measured
			Ranked
			Squared
			Rooted
5060	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (methyl methanesulfonate (mmf)-inducible fragment protein 1). [swissprot;acc:q15011]	HERPUD1	Measured
			Ranked
			Squared
			Rooted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.