MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Value Type	Rank	Gene	description	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 2008 to 2057 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
1004	o-sialoglycoprotein endopeptidase. [refseq;acc:nm_017807]	Divided	5903.72	5391.64	1.09498
1005	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]		6329.3	5780.34	1.09497
	seryl-trna synthetase, mitochondrial precursor (ec 6.1.1.11) (serine--trna ligase) (serrsmt). [swissprot;acc:q9np81]	Subtracted	6220.45	5680.76	539.69
1006	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]	Divided	6249.1	5707.73	1.09485
	seryl-trna synthetase (ec 6.1.1.11) (serine--trna ligase) (serrs). [swissprot;acc:p49591]	Subtracted	6220.45	5680.76	539.69
1007	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]		6245.55	5706.5	539.05
	hypoxia-inducible factor-3 alpha isoform a; inhibitory pas domain protein. [refseq;acc:nm_152794]	Divided	6249.1	5707.73	1.09485
1008	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Subtracted	3093.78	2554.89	538.89
	single-minded homolog 1. [swissprot;acc:p81133]	Divided	6249.1	5707.73	1.09485
1009	heparin sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.-) (n- hsst) (n-heparin sulfate sulfotransferase) (glucosaminyl n- deacetylase/n-sulfotransferase). [swissprot;acc:p52849]	Subtracted	5749.33	5210.58	538.75
	synapsin iii. [swissprot;acc:o14994]	Divided	6340.86	5791.82	1.0948
1010	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	n-deacetylase/n-sulfotransferase (heparan glucosaminyl) 3. [refseq;acc:nm_004784]	Subtracted	5749.33	5210.58	538.75
1011	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	Divided	6340.86	5791.82	1.0948
	n-deacetylase/n-sulfotransferase 4. [refseq;acc:nm_022569]	Subtracted	5749.33	5210.58	538.75
1012	actin binding lim protein 2. [refseq;acc:nm_032432]	Divided	6340.86	5791.82	1.0948
	heparan sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.8) (n-hsst) (hsnst) ([heparan sulfate]-glucosamine n-sulfotransferase) (n-heparan sulfate sulfotransferase) (glucosaminyl n-deacetylase/n- sulfotransferase). [swissprot;acc:p52848]	Subtracted	5749.33	5210.58	538.75
1013	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	Divided	6340.86	5791.82	1.0948
	protein cdc27hs (cell division cycle protein 27 homolog) (h-nuc). [swissprot;acc:p30260]	Subtracted	5749.33	5210.58	538.75
1014	synapsin ii. [swissprot;acc:q92777]	Divided	6340.86	5791.82	1.0948
	uridine kinase-like 1. [swissprot;acc:q9nwz5]	Subtracted	6086.89	5548.78	538.11
1015	acetyl-coa carboxylase 2 (ec 6.4.1.2) (acc-beta) [includes: biotin carboxylase (ec 6.3.4.14)]. [swissprot;acc:o00763]		7775.21	7237.39	537.82
	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	Divided	6340.86	5791.82	1.0948
1016	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]
	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]	Subtracted	4426.74	3889.27	537.47
1017	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]	Divided	6340.86	5791.82	1.0948
	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	Subtracted	4426.74	3889.27	537.47
1018	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]
	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	Divided	6340.86	5791.82	1.0948
1019	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]
	nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274]	Subtracted	6241.36	5704	537.36
1020	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]	Divided	6340.86	5791.82	1.0948
	serine/threonine protein phosphatase 6 (ec 3.1.3.16) (pp6). [swissprot;acc:o00743]	Subtracted	7771.58	7234.61	536.97
1021	sporulation-induced transcript 4-associated protein. [refseq;acc:nm_018312]
	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	Divided	6340.86	5791.82	1.0948
1022	protein kinase clk2 (ec 2.7.1.-) (cdc-like kinase 2). [swissprot;acc:p49760]		7045.75	6435.94	1.09475
	tetratricopeptide repeat protein 4 (my044 protein). [swissprot;acc:o95801]	Subtracted	7320.39	6783.78	536.61
1023	acetyl-coa carboxylase 1 (ec 6.4.1.2) (acc-alpha) [includes: biotin carboxylase (ec 6.3.4.14)]. [swissprot;acc:q13085]		7768.35	7232.14	536.21
	protein kinase clk3 (ec 2.7.1.-) (cdc-like kinase 3). [swissprot;acc:p49761]	Divided	7044.65	6435.02	1.09474
1024	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]		6245.55	5706.5	1.09446
	topoisomerase-related function protein 4-2. [refseq;acc:nm_022447]	Subtracted	5261.06	4725.28	535.78
1025	nadph:adrenodoxin oxidoreductase, mitochondrial precursor (ec 1.18.1.2) (adrenodoxin reductase) (ar) (ferredoxin-nadp(+) reductase). [swissprot;acc:p22570]		6481.56	5947.53	534.03
	phosphomannomutase 2 (ec 5.4.2.8) (pmm 2). [swissprot;acc:o15305]	Divided	6031.95	5511.96	1.09434
1026	limbic system-associated membrane protein precursor (lsamp). [swissprot;acc:q13449]	Subtracted	5929.41	5396.36	533.05
	phosphomannomutase 1 (ec 5.4.2.8) (pmm 1) (pmmh-22). [swissprot;acc:q92871]	Divided	6029.29	5509.89	1.09427
1027	opioid binding protein/cell adhesion molecule precursor (obcam) (opioid-binding cell adhesion molecule) (opcml). [swissprot;acc:q14982]	Subtracted	5939.42	5406.5	532.92
	s-adenosylmethionine synthetase gamma form (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-ii). [swissprot;acc:p31153]	Divided	6700.05	6123.15	1.09422
1028	neurotrimin precursor (hnt). [swissprot;acc:q9p121]	Subtracted	5946.46	5413.63	532.83
	nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274]	Divided	6241.36	5704	1.09421
1029	beta-catenin (pro2286). [swissprot;acc:p35222]		6166.09	5635.26	1.0942

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.