MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1932 to 1981 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
eukaryotic peptide chain release factor subunit 1 (erf1) (eukaryotic release factor 1) (tb3-1) (c11 protein). [swissprot;acc:p46055]	772	ETF1	Divided	210.946	221.225	1.04873
eukaryotic translation initiation factor 2 subunit 1 (eukaryotic translation initiation factor 2 alpha subunit) (eif-2-alpha) (eif- 2alpha) (eif-2a). [swissprot;acc:p05198]	1269	EIF2S1	Subtracted	226.433	231.491	5.058
	1341		Divided			1.02234
eukaryotic translation initiation factor 2 subunit 2 (eukaryotic translation initiation factor 2 beta subunit) (eif-2-beta). [swissprot;acc:p20042]	1798	EIF2S2	Subtracted	221.525	224.001	2.476
	1839		Divided			1.01118
eukaryotic translation initiation factor 2 subunit 3 (eukaryotic translation initiation factor 2 gamma subunit) (eif-2-gamma). [swissprot;acc:p41091]	1832	EIF2S3	Subtracted	221.639	224.046	2.407
	1865		Divided			1.01086
eukaryotic translation initiation factor 3 subunit 10 (eif-3 theta) (eif3 p167) (eif3 p180) (eif3 p185) (eif3a). [swissprot;acc:q14152]	816	EIF3A	Subtracted	246.354	237.223	9.131
	904		Divided			1.03849
eukaryotic translation initiation factor 3 subunit 11 (eif-3 p25) (eif3k) (muscle specific gene m9 protein) (ptd001) (hspc029) (arg134). [swissprot;acc:q9ubq5]	1548	EIF3K	Subtracted	221.128	224.767	3.639
	1565		Divided			1.01646
eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]	666	EIF3I	Subtracted	250.465	238.38	12.085
	746		Divided			1.0507
eukaryotic translation initiation factor 3 subunit 4 (eif-3 delta) (eif3 p44) (eif-3 rna-binding subunit) (eif3 p42) (eif3g). [swissprot;acc:o75821]	815	EIF3G	Subtracted	246.354	237.223	9.131
	903		Divided			1.03849
eukaryotic translation initiation factor 3 subunit 6 interacting protein (hspc021/hspc025). [swissprot;acc:q9y262]	1554	EIF3EIP	Subtracted	221.128	224.767	3.639
	1571		Divided			1.01646
eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371]	1904	EIF3D	Subtracted	219.753	217.574	2.179
	1931		Divided			1.01001
eukaryotic translation initiation factor 3 subunit 8 (eif3 p110) (eif3c). [swissprot;acc:q99613]	1271	EIF3C	Subtracted	245.532	240.483	5.049
	1405		Divided			1.021
eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]	765	EIF3B	Subtracted	243.067	232.805	10.262
	822		Divided			1.04408
eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	215	EIF4G1	Subtracted	237.292	212.457	24.835
	252		Divided			1.11689
eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	207	EIF4G3	Subtracted	237.312	212.363	24.949
	246		Divided			1.11748
eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730]	583	EIF4E	Subtracted	233.725	220.751	12.974
	649		Divided			1.05877
eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	176	EIF5	Subtracted	271.016	244.167	26.849
	268		Divided			1.10996
eukaryotic translation initiation factor 5a (eif-5a) (eif-4d) (rev- binding factor). [swissprot;acc:p10159]	2102	EIF5AP1		208.727	210.263	1.00736
	2120		Subtracted			1.536
eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]	486	EIF6		248.866	233.287	15.579
	545		Divided			1.06678
evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	556	GPATCH1	Subtracted	227.86	213.945	13.915
	573		Divided			1.06504
evolutionarily conserved signaling intermediate in toll pathway; ecsit. [refseq;acc:nm_016581]	2088	ECSIT	Subtracted	211.992	210.369	1.623
	2092		Divided			1.00772
exocyst complex component exo70. [swissprot;acc:q9upt5]	2781	EXOC7		0.00001	0.00001	1
			Subtracted	0	0	0
exocyst complex component sec10 (hsec10). [swissprot;acc:o00471]	721	EXOC5	Divided	214.765	203.8	1.0538
			Subtracted			10.965
exocyst complex component sec15a. [swissprot;acc:q8tag9]	738	EXOC6		222.138	211.503	10.635
	750		Divided			1.05028
exocyst complex component sec15b. [swissprot;acc:q9y2d4]	737	EXOC6B	Subtracted	221.968	211.326	10.642
	749		Divided			1.05036
exocyst complex component sec3 (bm-012). [swissprot;acc:q9nv70]	2484	EXOC1	Subtracted	218.093	218.72	0.627
	2487		Divided			1.00287
exocyst complex component sec5. [swissprot;acc:q96kp1]	986	EXOC2		116.771	120.707	1.03371

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.