MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1932 to 1981 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	red	green	network_comparison
1932	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	no value	196.965	198.936	1.01001
1933	ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480]	OTC	215.667	217.82	1.00998
1934	gamma adducin (adducin-like protein 70). [swissprot;acc:q9uey8]	ADD3	224.264	222.055	1.00995
1935	abhydrolase domain containing protein 2 (protein phps1-2). [swissprot;acc:p08910]	ABHD2	218.43	216.279
1936	creatine kinase, sarcomeric mitochondrial precursor (ec 2.7.3.2) (s- mtck) (mib-ck) (basic-type mitochondrial creatine kinase). [swissprot;acc:p17540]	CKMT2	198.3	196.347
1937	quaking isoform 6. [sptrembl;acc:q9p0x9]	QKI	218.43	216.279
1938	creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]	no value	198.293	196.341	1.00994
1939	peptidyl prolyl isomerase h; cyclophilin h. [refseq;acc:nm_006347]	PPIH	198.258	196.319	1.00988
1940	creatine kinase, b chain (ec 2.7.3.2) (b-ck). [swissprot;acc:p12277]	CKB	198.19	196.252
1941	prp18 pre-mrna processing factor 18 homolog. [refseq;acc:nm_003675]	PRPF18	198.258	196.319
1942	j domain protein c21orf55. [swissprot;acc:q9nx36]	C21orf55	198.257		1.00987
1943	megf11 protein. [refseq;acc:nm_032445]	MEGF11	224.34	222.147
1944	megf10 protein. [refseq;acc:nm_032446]	MEGF10	224.341	222.148
1945	beta adducin (erythrocyte adducin beta subunit). [swissprot;acc:p35612]	ADD2	224.343	222.151
1946	nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384]	NFIL3	214.234	212.142	1.00986
1947	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	PPP1R2	125.845	127.083	1.00984
1948	15 kda selenoprotein precursor. [swissprot;acc:o60613]	no value	214.522	212.432
1949	rna-binding protein with multiple splicing (rbp-ms). [swissprot;acc:q93062]	RBPMS	218.794	216.663
1950	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	VPS18	215.847	213.747	1.00982
1951	trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646]	TRIT1	205.876	203.873
1952	importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [swissprot;acc:p52294]	KPNA1	211.647	213.724	1.00981
1953	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	PPP1R2P9	125.912	127.146	1.0098
1954	voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448]	KCNAB3	211.632	213.703	1.00979
1955	yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [refseq;acc:nm_020470]	YIF1A	211.633		1.00978
1956	voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722]	KCNAB1
1957	similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557]	YIF1B
1958	aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]	AKR7A3
1959	alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]	ABHD3
1960	golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799]	YIPF5
1961	alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]	ABHD1
1962	methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252]	ALDH6A1	211.632	213.702
1963	10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	HSPE1	211.633	213.703
1964	rab acceptor 1 (prenylated); prenylated rab acceptor 1. [refseq;acc:nm_006423]	RABAC1
1965	alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611]	ADD1	224.432	222.258
1966	oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [swissprot;acc:q9y3b8]	REXO2	211.633	213.703
1967	choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329]	CHAT	211.632	213.702
1968	voltage-gated potassium channel beta-2 subunit (k+ channel beta-2 subunit) (kv-beta-2) (hkvbeta2). [swissprot;acc:q13303]	KCNAB2	211.633	213.703
1969	aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [swissprot;acc:o43488]	AKR7A2
1970	importin alpha-6 subunit (karyopherin alpha-5 subunit). [swissprot;acc:o15131]	KPNA6	211.62	213.683	1.00975
1971	creatine kinase, m chain (ec 2.7.3.2) (m-ck). [swissprot;acc:p06732]	CKM	198.258	196.346	1.00974
1972	regucalcin gene promotor region related protein; rgpr-p117. [refseq;acc:nm_033127]	SEC16B	219.777	217.659	1.00973
1973	wiskott-aldrich syndrome protein family member 2 (wasp-family protein member 2) (verprolin homology domain-containing protein 2). [swissprot;acc:q9y6w5]	no value	214.611	212.546	1.00972
1974	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]	WASF3
1975	wiskott-aldrich syndrome protein family member 1 (wasp-family protein member 1) (verprolin homology domain-containing protein 1). [swissprot;acc:q92558]	WASF1
1976	rest corepressor. [refseq;acc:nm_015156]	RCOR1
1977	homolog of yeast maf1. [refseq;acc:nm_032272]	MAF1	209.539	207.529	1.00969
1978	tumor differentially expressed protein 2. [refseq;acc:nm_178865]	SERINC2
1979	tumor differentially expressed protein 1 (transmembrane protein sbbi99). [swissprot;acc:q13530]	SERINC3
1980	tumor differentially expressed 1 protein like. [swissprot;acc:q9nrx5]	SERINC1
1981	d-3-phosphoglycerate dehydrogenase (ec 1.1.1.95) (3-pgdh). [swissprot;acc:o43175]	PHGDH

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.