MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

description	Gene	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 194 to 243 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Hugo	red	network_comparison	green
5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	Subtracted	893	PRKAG2	212.002	8.048	203.954
5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	Divided	878	PRKAG3		1.03946
	Subtracted	891			8.048
5'-methylthioadenosine phosphorylase (ec 2.4.2.28) (mta phosphorylase) (mtapase). [swissprot;acc:q13126]	Divided	1769	MTAP	223.016	1.01219	225.734
	Subtracted	1746			2.718
5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]	Divided	1021	TYRP1	221.278	1.03204	214.409
	Subtracted	1002			6.869
5-aminolevulinic acid synthase, erythroid-specific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-e). [swissprot;acc:p22557]	Divided	2491	ALAS2	194.527	1.00284	195.08
	Subtracted	2502			0.553
5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-h). [swissprot;acc:p13196]	Divided	2496	ALAS1		1.00284
	Subtracted	2507			0.553
5-formyltetrahydrofolate cyclo-ligase (ec 6.3.3.2) (5,10-methenyl- tetrahydrofolate synthetase) (methenyl-thf synthetase) (mthfs). [swissprot;acc:p49914]	Divided	2754	MTHFS	210.638	1.00002	210.642
	Subtracted				0.004
5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707]	Divided	1921	MTR	221.607	1.01012	219.386
	Subtracted	1884			2.221
54 kda nuclear rna- and dna-binding protein (p54(nrb)) (p54nrb) (55 kda nuclear protein) (nmt55) (non-pou domain-containing octamer- binding protein) (dna-binding p52/p100 complex, 52 kda subunit). [swissprot;acc:q15233]	Divided	2532	NONO	190.405	1.00214	190.812
	Subtracted	2538			0.407
6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858]	Divided	1822	PFKL	240.32	1.01151	243.085
	Subtracted	1733			2.765
6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [swissprot;acc:p08237]	Divided	1830	PFKM		1.01144	243.069
	Subtracted	1737			2.749
6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [swissprot;acc:q01813]	Divided	1883	PFKP	240.317	1.01067	242.881
	Subtracted	1777			2.564
6-phosphogluconate dehydrogenase, decarboxylating (ec 1.1.1.44). [swissprot;acc:p52209]	Divided	2274	PGD	213.642	1.00542	214.801
	Subtracted	2269			1.159
6-phosphogluconolactonase (ec 3.1.1.31) (6pgl). [swissprot;acc:o95336]	Divided	1584	PGLS	216.891	1.01633	220.432
	Subtracted	1577			3.541
6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [swissprot;acc:q03393]	Divided	2904	PTS	0.00001	1	0.00001
	Subtracted			0	0	0
60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [swissprot;acc:p10809]	Divided	2588	HSPD1	222.305	1.00151	222.64
	Subtracted	2574			0.335
60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]	Divided	826	HTATIP	223.186	1.04335	213.912
	Subtracted	808			9.274
60s acidic ribosomal protein p0 (l10e). [swissprot;acc:p05388]	Divided	1092	RPLP0	226.203	1.02941	232.855
	Subtracted	1022			6.652
60s acidic ribosomal protein p1. [swissprot;acc:p05386]	Divided	898	no value	229.171	1.03874	238.048
	Subtracted	831			8.877
60s acidic ribosomal protein p2. [swissprot;acc:p05387]	Divided	720	RPLP2	231.92	1.05396	244.435
	Subtracted	621			12.515
60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	Divided	357	no value	243.12	1.09683	266.661
	Subtracted	267			23.541
60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]	Divided	356		243.24	1.09684	266.796
	Subtracted	264			23.556
60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7]	Divided	373	MRPL11	242.37	1.09442	265.255
	Subtracted	283			22.885
60s ribosomal protein l11. [swissprot;acc:p39026]	Divided		RPL11	241.828	1.10552	267.346
	Subtracted	201			25.518
60s ribosomal protein l12 like protein. [sptrembl;acc:o60886]	Divided	338	no value	243.583	1.0983	267.528
	Subtracted	246			23.945
60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815]	Divided	369	MRPL12	242.159	1.09475	265.104

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.