MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1930 to 1979 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
965	PARD6G	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	Divided	211.987	204.964	1.03426
966	SORBS3	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	Subtracted	211.812	204.732	7.08
	TUB	tubby protein homolog. [swissprot;acc:p50607]	Divided	211.987	204.964	1.03426
967	no value	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]	Subtracted	231.277	238.356	7.079
	PRKCI	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]	Divided	211.987	204.964	1.03426
968	no value	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Subtracted	132.413	125.389	7.024
	NUMB	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	Divided	211.987	204.964	1.03426
969	HOXB4	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Subtracted	132.413	125.389	7.024
	TBC1D5	tbc1 domain family member 5. [swissprot;acc:q92609]	Divided	211.987	204.964	1.03426
970	HOXC5	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Subtracted	132.413	125.389	7.024
	TULP1	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]	Divided	211.987	204.964	1.03426
971	no value	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Subtracted	132.413	125.389	7.024
	VPS29	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	Divided	211.987	204.964	1.03426
972	HOXD4	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Subtracted	132.413	125.389	7.024
	NUMBL	numb-like protein (numb-r). [swissprot;acc:q9y6r0]	Divided	211.987	204.964	1.03426
973	HOXB5	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Subtracted	132.413	125.389	7.024
	TULP3	tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]	Divided	211.987	204.964	1.03426
974	HOXA5	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Subtracted	132.413	125.389	7.024
	VPS35	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	Divided	211.987	204.964	1.03426
975	no value	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	Subtracted	132.413	125.389	7.024
	PRKCZ	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	Divided	211.987	204.964	1.03426
976	HSD17B14	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Subtracted	132.413	125.389	7.024
	WDR36	t-cell activation wd repeat protein. [refseq;acc:nm_139281]	Divided	243.34	235.322	1.03407
977	PARD6G	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	Subtracted	211.987	204.964	7.023
	PFDN5	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	Divided	228.953	221.421	1.03402
978	no value	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]
	TUB	tubby protein homolog. [swissprot;acc:p50607]	Subtracted	211.987	204.964	7.023
979	BLOC1S1	gcn5-like protein 1 (rt14 protein). [swissprot;acc:p78537]	Divided	202.027	195.386	1.03399
	PRKCI	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]	Subtracted	211.987	204.964	7.023
980	BRAF	b-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (p94) (v-raf murine sarcoma viral oncogene homolog b1). [swissprot;acc:p15056]	Divided	130.289	134.713	1.03396
	NUMB	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	Subtracted	211.987	204.964	7.023
981	EXOC3	exocyst complex component sec6. [swissprot;acc:o60645]	Divided	207.186	200.398	1.03387
	TBC1D5	tbc1 domain family member 5. [swissprot;acc:q92609]	Subtracted	211.987	204.964	7.023
982	CIRH1A	cirhin; testis expressed gene 292; cirrhosis, autosomal recessive 1a. [refseq;acc:nm_032830]	Divided	243.312	235.351	1.03383
	TULP1	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]	Subtracted	211.987	204.964	7.023
983	RSL1D1	pbk1 protein. [sptrembl;acc:o76021]	Divided	243.312	235.353	1.03382
	VPS29	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	Subtracted	211.987	204.964	7.023
984	NUMBL	numb-like protein (numb-r). [swissprot;acc:q9y6r0]
	PAPOLA	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]	Divided	116.71	120.654	1.03379
985	PDCD5	programmed cell death protein 5 (tfar19 protein) (tf-1 cell apoptosis related gene-19 protein). [swissprot;acc:o14737]		233.402	225.782	1.03375
	TULP3	tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]	Subtracted	211.987	204.964	7.023
986	EXOC2	exocyst complex component sec5. [swissprot;acc:q96kp1]	Divided	116.771	120.707	1.03371
	VPS35	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	Subtracted	211.987	204.964	7.023
987	HTRA2	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	Divided	218.459	211.338	1.03369
	PRKCZ	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	Subtracted	211.987	204.964	7.023
988	no value	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]		236.679	243.679	7
	HTRA4	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	Divided	218.461	211.343	1.03368
989	no value	zinc finger protein 277. [swissprot;acc:q9nrm2]	Subtracted	236.679	243.679	7
	HTRA3	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]	Divided	218.462	211.345	1.03367
990	DDX52	atp-dependent rna helicase rok1; atp-dependent rna helicase. [refseq;acc:nm_007010]		243.297	235.373

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.