MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1925 to 1974 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
963	CCNG1	cyclin g1 (cyclin g). [swissprot;acc:p51959]	High confidence	130.066	134.527	1.0343
	ITM2B	integral membrane protein 2b (transmembrane protein bri) [contains: abri/adan amyloid peptide]. [swissprot;acc:q9y287]	Low confidence	201.992	197.121	1.02471
964	ITM2C	integral membrane protein 2c (transmembrane protein bri3) (npd018). [swissprot;acc:q9nqx7]
	PPP2R5A	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	High confidence	130.066	134.527	1.0343
965	ITM2A	integral membrane protein 2a (e25 protein). [swissprot;acc:o43736]	Low confidence	201.992	197.121	1.02471
	PARD6G	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	High confidence	211.987	204.964	1.03426
966	PA2G4	proliferation-associated protein 2g4 (cell cycle protein p38-2g4 homolog) (hg4-1). [swissprot;acc:q9uq80]	Low confidence	206.197	201.227	1.0247
	TUB	tubby protein homolog. [swissprot;acc:p50607]	High confidence	211.987	204.964	1.03426
967	PRKCI	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]
	WNK2	lysine-deficient protein kinase 2; mitogen-activated protein kinase kinase kinase; serologically defined colon cancer antigen 43. [refseq;acc:nm_006648]	Low confidence	204.782	199.848	1.02469
968	NUMB	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	High confidence	211.987	204.964	1.03426
	WNK4	protein kinase, lysine deficient 4; putative protein kinase wnk4. [refseq;acc:nm_032387]	Low confidence	204.782	199.848	1.02469
969	no value	protein kinase, lysine deficient 3. [refseq;acc:nm_020922]
	TBC1D5	tbc1 domain family member 5. [swissprot;acc:q92609]	High confidence	211.987	204.964	1.03426
970	TULP1	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]
	WNK1	protein kinase, lysine deficient 1; kinase deficient protein. [refseq;acc:nm_018979]	Low confidence	204.782	199.848	1.02469
971	no value	exonuclease nef-sp. [refseq;acc:nm_030941]
	VPS29	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	High confidence	211.987	204.964	1.03426
972	ATP5J	atp synthase coupling factor 6, mitochondrial precursor (ec 3.6.3.14) (f6). [swissprot;acc:p18859]	Low confidence	202.474	197.597	1.02468
	NUMBL	numb-like protein (numb-r). [swissprot;acc:q9y6r0]	High confidence	211.987	204.964	1.03426
973	TULP3	tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]
	ZW10	centromere/kinetochore protein zw10 homolog. [swissprot;acc:o43264]	Low confidence	202.474	197.597	1.02468
974	VPS35	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	High confidence	211.987	204.964	1.03426
	YBX1	nuclease sensitive element binding protein 1 (y box binding protein-1) (y-box transcription factor) (yb-1) (ccaat-binding transcription factor i subunit a) (cbf-a) (enhancer factor i subunit a) (efi-a) (dna-binding protein b) (dbpb). [swissprot;acc:p16991]	Low confidence	204.273	199.353	1.02468
975	EIF5B	translation initiation factor if-2. [swissprot;acc:o60841]		202.576	197.699	1.02467
	PRKCZ	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	High confidence	211.987	204.964	1.03426
976	SLC5A8	solute carrier family 5 (iodide transporter), member 8; apical iodide transporter. [refseq;acc:nm_145913]	Low confidence	200.046	195.23	1.02467
	WDR36	t-cell activation wd repeat protein. [refseq;acc:nm_139281]	High confidence	243.34	235.322	1.03407
977	PFDN5	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]		228.953	221.421	1.03402
	SLC5A6	sodium-dependent multivitamin transporter (na(+)-dependent multivitamin transporter). [swissprot;acc:q9y289]	Low confidence	200.046	195.231	1.02466
978	no value	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]	High confidence	228.953	221.421	1.03402
	TRIP10	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	Low confidence	201.137	196.296	1.02466
979	no value	vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670]		196.475	191.748	1.02465
	BLOC1S1	gcn5-like protein 1 (rt14 protein). [swissprot;acc:p78537]	High confidence	202.027	195.386	1.03399
980	BRAF	b-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (p94) (v-raf murine sarcoma viral oncogene homolog b1). [swissprot;acc:p15056]		130.289	134.713	1.03396
	PDCL3	iap-associated factor viaf1; phosducin-like 2. [refseq;acc:nm_024065]	Low confidence	201.185	196.346	1.02465
981	ABHD11	williams beuren syndrome chromosome region 21 isoform 1. [refseq;acc:nm_148912]		201.186	196.347
	EXOC3	exocyst complex component sec6. [swissprot;acc:o60645]	High confidence	207.186	200.398	1.03387
982	CIRH1A	cirhin; testis expressed gene 292; cirrhosis, autosomal recessive 1a. [refseq;acc:nm_032830]		243.312	235.351	1.03383
	USP13	ubiquitin carboxyl-terminal hydrolase 13 (ec 3.1.2.15) (ubiquitin thiolesterase 13) (ubiquitin-specific processing protease 13) (deubiquitinating enzyme 13) (isopeptidase t-3) (isot-3). [swissprot;acc:q92995]	Low confidence	204.318	199.402	1.02465
983	FNBP1	ba138e2.1.2 (formin-binding protein 17 (fbp17), isoform 2). [sptrembl;acc:q96lh6]		201.215	196.378	1.02463
	RSL1D1	pbk1 protein. [sptrembl;acc:o76021]	High confidence	243.312	235.353	1.03382
984	CTSA	lysosomal protective protein precursor (ec 3.4.16.5) (cathepsin a) (carboxypeptidase c) (protective protein for beta-galactosidase). [swissprot;acc:p10619]	Low confidence	201.065	196.232	1.02463
	PAPOLA	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]	High confidence	116.71	120.654	1.03379
985	ATG4A	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Low confidence	151.012	154.728	1.02461
	PDCD5	programmed cell death protein 5 (tfar19 protein) (tf-1 cell apoptosis related gene-19 protein). [swissprot;acc:o14737]	High confidence	233.402	225.782	1.03375
986	ANLN	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	Low confidence	192.111	187.496	1.02461
	EXOC2	exocyst complex component sec5. [swissprot;acc:q96kp1]	High confidence	116.771	120.707	1.03371
987	HTRA2	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]		218.459	211.338	1.03369
	WDR68	wd-repeat protein an11 homolog. [swissprot;acc:o15491]	Low confidence	200.981	196.157	1.02459

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.