MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1913 to 1962 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	red	network_comparison	green
1913	no value	phospholipid scramblase 3 (pl scramblase 3) (ca(2+)-dependent phospholipid scramblase 3). [swissprot;acc:q9nry6]	215.745	1.01021	213.564
1914	PLSCR4	phospholipid scramblase 4 (pl scramblase 4) (ca(2+)-dependent phospholipid scramblase 4). [swissprot;acc:q9nrq2]
1915	PLSCR2	phospholipid scramblase 2 (pl scramblase 2) (ca(2+)-dependent phospholipid scramblase 2). [swissprot;acc:q9nry7]	215.747	1.01019	213.571
1916	RHCG	rh type c glycoprotein. [refseq;acc:nm_016321]	196.88	1.01016	198.88
1917	ING5	p28 ing5. [refseq;acc:nm_032329]	215.848	1.01015	218.039
1918	MED28	endothelial-derived gene 1. [refseq;acc:nm_025205]	202.211		200.18
1919	HARS2	histidyl-trna synthetase homolog (ec 6.1.1.21) (histidine--trna ligase homolog) (hisrs). [swissprot;acc:p49590]	187.231		185.349
1920	HARS	histidyl-trna synthetase (ec 6.1.1.21) (histidine--trna ligase) (hisrs). [swissprot;acc:p12081]	187.292	1.01013	185.413
1921	MTR	5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707]	221.607	1.01012	219.386
1922	CENTG2	centaurin gamma 2. [swissprot;acc:q9upq3]	220.659	1.0101	218.452
1923	USO1	general vesicular transport factor p115 (transcytosis associated protein) (tap) (vesicle docking protein). [swissprot;acc:o60763]
1924	CENTG1	centaurin gamma 1. [swissprot;acc:q99490]
1925	CENTG3	centaurin gamma 3. [swissprot;acc:q96p47]
1926	RHBG	rhesus blood group, b glycoprotein; rh type b glycoprotein. [refseq;acc:nm_020407]	196.925	1.01008	198.91
1927	RHAG	rhesus blood group-associated glycoprotein (erythrocyte plasma membrane 50 kda glycoprotein) (rh50a). [swissprot;acc:q02094]	196.932	1.01006	198.914
1928	RHD	blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	196.964	1.01001	198.935
1929	no value	enigma protein; lim domain protein. [refseq;acc:nm_005451]	219.753		217.574
1930		blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	196.964		198.935
1931	EIF3D	eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371]	219.753		217.574
1932	no value	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	196.965		198.936
1933	OTC	ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480]	215.667	1.00998	217.82
1934	ADD3	gamma adducin (adducin-like protein 70). [swissprot;acc:q9uey8]	224.264	1.00995	222.055
1935	ABHD2	abhydrolase domain containing protein 2 (protein phps1-2). [swissprot;acc:p08910]	218.43		216.279
1936	CKMT2	creatine kinase, sarcomeric mitochondrial precursor (ec 2.7.3.2) (s- mtck) (mib-ck) (basic-type mitochondrial creatine kinase). [swissprot;acc:p17540]	198.3		196.347
1937	QKI	quaking isoform 6. [sptrembl;acc:q9p0x9]	218.43		216.279
1938	no value	creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]	198.293	1.00994	196.341
1939	PPIH	peptidyl prolyl isomerase h; cyclophilin h. [refseq;acc:nm_006347]	198.258	1.00988	196.319
1940	CKB	creatine kinase, b chain (ec 2.7.3.2) (b-ck). [swissprot;acc:p12277]	198.19		196.252
1941	PRPF18	prp18 pre-mrna processing factor 18 homolog. [refseq;acc:nm_003675]	198.258		196.319
1942	C21orf55	j domain protein c21orf55. [swissprot;acc:q9nx36]	198.257	1.00987
1943	MEGF11	megf11 protein. [refseq;acc:nm_032445]	224.34		222.147
1944	MEGF10	megf10 protein. [refseq;acc:nm_032446]	224.341		222.148
1945	ADD2	beta adducin (erythrocyte adducin beta subunit). [swissprot;acc:p35612]	224.343		222.151
1946	NFIL3	nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384]	214.234	1.00986	212.142
1947	PPP1R2	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	125.845	1.00984	127.083
1948	no value	15 kda selenoprotein precursor. [swissprot;acc:o60613]	214.522		212.432
1949	RBPMS	rna-binding protein with multiple splicing (rbp-ms). [swissprot;acc:q93062]	218.794		216.663
1950	VPS18	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	215.847	1.00982	213.747
1951	TRIT1	trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646]	205.876		203.873
1952	KPNA1	importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [swissprot;acc:p52294]	211.647	1.00981	213.724
1953	PPP1R2P9	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	125.912	1.0098	127.146
1954	KCNAB3	voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448]	211.632	1.00979	213.703
1955	YIF1A	yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [refseq;acc:nm_020470]	211.633	1.00978
1956	KCNAB1	voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722]
1957	YIF1B	similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557]
1958	AKR7A3	aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]
1959	ABHD3	alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]
1960	YIPF5	golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799]
1961	ABHD1	alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]
1962	ALDH6A1	methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252]	211.632		213.702

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.