MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1908 to 1957 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
954	TCIRG1	vacuolar proton translocating atpase 116 kda subunit a isoform 3 (v- atpase 116-kda isoform a3) (osteoclastic proton pump 116 kda subunit) (oc-116 kda) (oc116) (t-cell immune regulator 1) (t cell immune response cdna7 protein) (tirc7). [swissprot;acc:q13488]	Low confidence	190.801	186.183	1.0248
955	MRPL27	mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	High confidence	231.163	239.205	1.03479
	WASL	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Low confidence	198.172	193.377	1.0248
956	DHX15	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]		203.365	198.452	1.02476
	SORBS3	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	High confidence	211.812	204.732	1.03458
957	ARAF	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]		129.913	134.399	1.03453
	TAF6	transcription initiation factor tfiid 70 kda subunit (tafii-70) (tafii-80) (tafii80). [swissprot;acc:p49848]	Low confidence	201.82	196.944	1.02476
958	RAF1	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	High confidence	129.921	134.406	1.03452
	SNF1LK	probable serine/threonine protein kinase snf1lk (ec 2.7.1.-). [swissprot;acc:p57059]	Low confidence	194.842	190.136	1.02475
959	no value	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	High confidence	237.558	229.677	1.03431
	SSBP1	single-stranded dna-binding protein, mitochondrial precursor (mt-ssb) (mtssb) (pwp1-interacting protein 17). [swissprot;acc:q04837]	Low confidence	194.842	190.136	1.02475
960	SLC5A5	sodium/iodide cotransporter (na(+)/i(-) cotransporter) (sodium-iodide symporter) (na+/i-symporter). [swissprot;acc:q92911]		200.05	195.223	1.02473
	ZRF1	zuotin related factor-1 (m-phase phosphoprotein 11). [swissprot;acc:q99543]	High confidence	237.558	229.677	1.03431
961	PICALM	phosphatidylinositol-binding clathrin assembly protein (clathrin assembly lymphoid myeloid leukemia protein). [swissprot;acc:q13492]	Low confidence	203.548	198.638	1.02472
	PPP2R5E	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	High confidence	130.066	134.527	1.0343
962	CCNG2	cyclin g2. [swissprot;acc:q16589]
	POLH	polymerase (dna directed), eta. [refseq;acc:nm_006502]	Low confidence	201.09	196.241	1.02471
963	CCNG1	cyclin g1 (cyclin g). [swissprot;acc:p51959]	High confidence	130.066	134.527	1.0343
	ITM2B	integral membrane protein 2b (transmembrane protein bri) [contains: abri/adan amyloid peptide]. [swissprot;acc:q9y287]	Low confidence	201.992	197.121	1.02471
964	ITM2C	integral membrane protein 2c (transmembrane protein bri3) (npd018). [swissprot;acc:q9nqx7]
	PPP2R5A	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	High confidence	130.066	134.527	1.0343
965	ITM2A	integral membrane protein 2a (e25 protein). [swissprot;acc:o43736]	Low confidence	201.992	197.121	1.02471
	PARD6G	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	High confidence	211.987	204.964	1.03426
966	PA2G4	proliferation-associated protein 2g4 (cell cycle protein p38-2g4 homolog) (hg4-1). [swissprot;acc:q9uq80]	Low confidence	206.197	201.227	1.0247
	TUB	tubby protein homolog. [swissprot;acc:p50607]	High confidence	211.987	204.964	1.03426
967	PRKCI	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]
	WNK2	lysine-deficient protein kinase 2; mitogen-activated protein kinase kinase kinase; serologically defined colon cancer antigen 43. [refseq;acc:nm_006648]	Low confidence	204.782	199.848	1.02469
968	NUMB	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	High confidence	211.987	204.964	1.03426
	WNK4	protein kinase, lysine deficient 4; putative protein kinase wnk4. [refseq;acc:nm_032387]	Low confidence	204.782	199.848	1.02469
969	no value	protein kinase, lysine deficient 3. [refseq;acc:nm_020922]
	TBC1D5	tbc1 domain family member 5. [swissprot;acc:q92609]	High confidence	211.987	204.964	1.03426
970	TULP1	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]
	WNK1	protein kinase, lysine deficient 1; kinase deficient protein. [refseq;acc:nm_018979]	Low confidence	204.782	199.848	1.02469
971	no value	exonuclease nef-sp. [refseq;acc:nm_030941]
	VPS29	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	High confidence	211.987	204.964	1.03426
972	ATP5J	atp synthase coupling factor 6, mitochondrial precursor (ec 3.6.3.14) (f6). [swissprot;acc:p18859]	Low confidence	202.474	197.597	1.02468
	NUMBL	numb-like protein (numb-r). [swissprot;acc:q9y6r0]	High confidence	211.987	204.964	1.03426
973	TULP3	tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]
	ZW10	centromere/kinetochore protein zw10 homolog. [swissprot;acc:o43264]	Low confidence	202.474	197.597	1.02468
974	VPS35	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	High confidence	211.987	204.964	1.03426
	YBX1	nuclease sensitive element binding protein 1 (y box binding protein-1) (y-box transcription factor) (yb-1) (ccaat-binding transcription factor i subunit a) (cbf-a) (enhancer factor i subunit a) (efi-a) (dna-binding protein b) (dbpb). [swissprot;acc:p16991]	Low confidence	204.273	199.353	1.02468
975	EIF5B	translation initiation factor if-2. [swissprot;acc:o60841]		202.576	197.699	1.02467
	PRKCZ	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	High confidence	211.987	204.964	1.03426
976	SLC5A8	solute carrier family 5 (iodide transporter), member 8; apical iodide transporter. [refseq;acc:nm_145913]	Low confidence	200.046	195.23	1.02467
	WDR36	t-cell activation wd repeat protein. [refseq;acc:nm_139281]	High confidence	243.34	235.322	1.03407
977	PFDN5	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]		228.953	221.421	1.03402
	SLC5A6	sodium-dependent multivitamin transporter (na(+)-dependent multivitamin transporter). [swissprot;acc:q9y289]	Low confidence	200.046	195.231	1.02466
978	no value	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]	High confidence	228.953	221.421	1.03402
	TRIP10	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	Low confidence	201.137	196.296	1.02466
979	no value	vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670]		196.475	191.748	1.02465

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.