MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1908 to 1957 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	network_comparison	green
954	thioredoxin-like; pkc-interacting cousin of thioredoxin. [refseq;acc:nm_006541]	GLRX3	Subtracted	228.412	7.197	235.609
955	bai1-associated protein 1; ww domain-containing protein 3; atrophin-1 interacting protein 3. [refseq;acc:nm_004742]	MAGI1		221.73	7.176	228.906
	mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	MRPL27	Divided	231.163	1.03479	239.205
956	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	TCP1	Subtracted	135.379	7.154	128.225
	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	SORBS3	Divided	211.812	1.03458	204.732
957	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	ARAF		129.913	1.03453	134.399
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	RGL1	Subtracted	168.592	7.14	161.452
958	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	RAF1	Divided	129.921	1.03452	134.406
	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	HTRA2	Subtracted	218.459	7.121	211.338
959	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	no value	Divided	237.558	1.03431	229.677
	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	HTRA4	Subtracted	218.461	7.118	211.343
960	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]	HTRA3		218.462	7.117	211.345
	zuotin related factor-1 (m-phase phosphoprotein 11). [swissprot;acc:q99543]	ZRF1	Divided	237.558	1.03431	229.677
961	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	HTRA1	Subtracted	218.468	7.111	211.357
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	PPP2R5E	Divided	130.066	1.0343	134.527
962	cyclin g2. [swissprot;acc:q16589]	CCNG2
	mitotic spindle assembly checkpoint protein mad2b (mad2-like 2) (hrev7). [swissprot;acc:q9ui95]	MAD2L2	Subtracted	219.656	7.109	212.547
963	cyclin g1 (cyclin g). [swissprot;acc:p51959]	CCNG1	Divided	130.066	1.0343	134.527
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	no value	Subtracted	219.656	7.109	212.547
964	nuclear pore complex protein nup88 (nucleoporin nup88) (88 kda nuclear pore complex protein). [swissprot;acc:q99567]	NUP88
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	PPP2R5A	Divided	130.066	1.0343	134.527
965	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	PARD6G		211.987	1.03426	204.964
	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	CLEC3B	Subtracted	178.514	7.094	171.42
966	tubby protein homolog. [swissprot;acc:p50607]	TUB	Divided	211.987	1.03426	204.964
	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	SORBS3	Subtracted	211.812	7.08	204.732
967	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]	no value		231.277	7.079	238.356
	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]	PRKCI	Divided	211.987	1.03426	204.964
968	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	no value	Subtracted	132.413	7.024	125.389
	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	NUMB	Divided	211.987	1.03426	204.964
969	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	HOXB4	Subtracted	132.413	7.024	125.389
	tbc1 domain family member 5. [swissprot;acc:q92609]	TBC1D5	Divided	211.987	1.03426	204.964
970	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	HOXC5	Subtracted	132.413	7.024	125.389
	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]	TULP1	Divided	211.987	1.03426	204.964
971	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	no value	Subtracted	132.413	7.024	125.389
	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	VPS29	Divided	211.987	1.03426	204.964
972	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	HOXD4	Subtracted	132.413	7.024	125.389
	numb-like protein (numb-r). [swissprot;acc:q9y6r0]	NUMBL	Divided	211.987	1.03426	204.964
973	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	HOXB5	Subtracted	132.413	7.024	125.389
	tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]	TULP3	Divided	211.987	1.03426	204.964
974	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	HOXA5	Subtracted	132.413	7.024	125.389
	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	VPS35	Divided	211.987	1.03426	204.964
975	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	no value	Subtracted	132.413	7.024	125.389
	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	PRKCZ	Divided	211.987	1.03426	204.964
976	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	HSD17B14	Subtracted	132.413	7.024	125.389
	t-cell activation wd repeat protein. [refseq;acc:nm_139281]	WDR36	Divided	243.34	1.03407	235.322
977	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	PARD6G	Subtracted	211.987	7.023	204.964
	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	PFDN5	Divided	228.953	1.03402	221.421
978	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]	no value
	tubby protein homolog. [swissprot;acc:p50607]	TUB	Subtracted	211.987	7.023	204.964
979	gcn5-like protein 1 (rt14 protein). [swissprot;acc:p78537]	BLOC1S1	Divided	202.027	1.03399	195.386

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.