MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1908 to 1957 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
954	thioredoxin-like; pkc-interacting cousin of thioredoxin. [refseq;acc:nm_006541]	GLRX3	Subtracted	228.412	235.609	7.197
955	bai1-associated protein 1; ww domain-containing protein 3; atrophin-1 interacting protein 3. [refseq;acc:nm_004742]	MAGI1		221.73	228.906	7.176
	mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	MRPL27	Divided	231.163	239.205	1.03479
956	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	TCP1	Subtracted	135.379	128.225	7.154
	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	SORBS3	Divided	211.812	204.732	1.03458
957	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	ARAF		129.913	134.399	1.03453
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	RGL1	Subtracted	168.592	161.452	7.14
958	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	RAF1	Divided	129.921	134.406	1.03452
	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	HTRA2	Subtracted	218.459	211.338	7.121
959	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	no value	Divided	237.558	229.677	1.03431
	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	HTRA4	Subtracted	218.461	211.343	7.118
960	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]	HTRA3		218.462	211.345	7.117
	zuotin related factor-1 (m-phase phosphoprotein 11). [swissprot;acc:q99543]	ZRF1	Divided	237.558	229.677	1.03431
961	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	HTRA1	Subtracted	218.468	211.357	7.111
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	PPP2R5E	Divided	130.066	134.527	1.0343
962	cyclin g2. [swissprot;acc:q16589]	CCNG2
	mitotic spindle assembly checkpoint protein mad2b (mad2-like 2) (hrev7). [swissprot;acc:q9ui95]	MAD2L2	Subtracted	219.656	212.547	7.109
963	cyclin g1 (cyclin g). [swissprot;acc:p51959]	CCNG1	Divided	130.066	134.527	1.0343
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	no value	Subtracted	219.656	212.547	7.109
964	nuclear pore complex protein nup88 (nucleoporin nup88) (88 kda nuclear pore complex protein). [swissprot;acc:q99567]	NUP88
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	PPP2R5A	Divided	130.066	134.527	1.0343
965	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	PARD6G		211.987	204.964	1.03426
	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	CLEC3B	Subtracted	178.514	171.42	7.094
966	tubby protein homolog. [swissprot;acc:p50607]	TUB	Divided	211.987	204.964	1.03426
	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	SORBS3	Subtracted	211.812	204.732	7.08
967	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]	no value		231.277	238.356	7.079
	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]	PRKCI	Divided	211.987	204.964	1.03426
968	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	no value	Subtracted	132.413	125.389	7.024
	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	NUMB	Divided	211.987	204.964	1.03426
969	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	HOXB4	Subtracted	132.413	125.389	7.024
	tbc1 domain family member 5. [swissprot;acc:q92609]	TBC1D5	Divided	211.987	204.964	1.03426
970	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	HOXC5	Subtracted	132.413	125.389	7.024
	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]	TULP1	Divided	211.987	204.964	1.03426
971	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	no value	Subtracted	132.413	125.389	7.024
	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	VPS29	Divided	211.987	204.964	1.03426
972	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	HOXD4	Subtracted	132.413	125.389	7.024
	numb-like protein (numb-r). [swissprot;acc:q9y6r0]	NUMBL	Divided	211.987	204.964	1.03426
973	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	HOXB5	Subtracted	132.413	125.389	7.024
	tubby related protein 3 (tubby-like protein 3). [swissprot;acc:o75386]	TULP3	Divided	211.987	204.964	1.03426
974	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	HOXA5	Subtracted	132.413	125.389	7.024
	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	VPS35	Divided	211.987	204.964	1.03426
975	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	no value	Subtracted	132.413	125.389	7.024
	protein kinase c, zeta type (ec 2.7.1.37) (npkc-zeta). [swissprot;acc:q05513]	PRKCZ	Divided	211.987	204.964	1.03426
976	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	HSD17B14	Subtracted	132.413	125.389	7.024
	t-cell activation wd repeat protein. [refseq;acc:nm_139281]	WDR36	Divided	243.34	235.322	1.03407
977	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	PARD6G	Subtracted	211.987	204.964	7.023
	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	PFDN5	Divided	228.953	221.421	1.03402
978	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]	no value
	tubby protein homolog. [swissprot;acc:p50607]	TUB	Subtracted	211.987	204.964	7.023
979	gcn5-like protein 1 (rt14 protein). [swissprot;acc:p78537]	BLOC1S1	Divided	202.027	195.386	1.03399

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.