MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1894 to 1943 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
474	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	Rooted	62.574	68.4128	1.09331
	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	Ranked	226.789	210.818	1.07576
	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	Measured	9649.61	11053.5	1.14549
475	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	Rooted	62.574	68.4128	1.09331
	map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	Measured	9649.61	11053.5	1.14549
	phosphoglycerate kinase 1 (ec 2.7.2.3) (primer recognition protein 2) (prp 2). [swissprot;acc:p00558]	Squared	28192	33985.3	1.20549
	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]	Ranked	226.727	210.816	1.07547
476	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	Measured	9649.61	11053.5	1.14549
	potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]	Ranked	226.681	210.814	1.07527
	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Rooted	62.574	68.4128	1.09331
	vav proto-oncogene. [swissprot;acc:p15498]	Squared	31223.8	37614.3	1.20467
477	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	Rooted	62.574	68.4128	1.09331
	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	Measured	9649.61	11053.5	1.14549
	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]	Ranked	251.926	234.547	1.0741
	vav-3 protein. [swissprot;acc:q9ukw4]	Squared	31248.8	37623.4	1.204
478	histone h2b.c (h2b/c). [swissprot;acc:q99880]	Rooted	50.6084	55.2961	1.09263
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Squared	16318.4	19645.8	1.2039
	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	Measured	9649.61	11053.5	1.14549
	transcription factor iiib 90 kda subunit (tfiiib90) (htfiiib90) (b- related factor 1) (hbrf) (tata box-binding protein-associated factor, rna polymerase iii, subunit 2) (taf3b2). [swissprot;acc:q92994]	Ranked	228.051	212.321	1.07409
479	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	Rooted	50.6084	55.2961	1.09263
	nucleolar protein family a, member 1; gar1 protein. [refseq;acc:nm_018983]	Ranked	228.051	212.321	1.07409
	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	Measured	9649.61	11053.5	1.14549
	translation initiation factor if-2. [swissprot;acc:o60841]	Squared	24031.6	28929.7	1.20382
480	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	Rooted	50.6084	55.2961	1.09263
	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	Measured	9649.61	11053.5	1.14549
	neuropilin- and tolloid-like protein 2 precursor. [refseq;acc:nm_018092]	Ranked	237.109	254.667	1.07405
	phosphatidate cytidylyltransferase 1 (ec 2.7.7.41) (cdp-diglyceride synthetase 1) (cdp-diglyceride pyrophosphorylase 1) (cdp- diacylglycerol synthase 1) (cds 1) (ctp:phosphatidate cytidylyltransferase 1) (cdp-dag synthase 1) (cdp-dg synthetase 1). [swissprot;acc:q92903]	Squared	26874.6	32347.4	1.20364
481	histone h2b. [refseq;acc:nm_175055]	Rooted	50.6084	55.2961	1.09263
	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	Measured	9649.61	11053.5	1.14549
	neuropilin- and tolloid-like protein 1 isoform 3 precursor. [refseq;acc:nm_138966]	Ranked	237.109	254.667	1.07405
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Squared	16335.9	19660.7	1.20353
482	heterogenous nuclear ribonucleoprotein u (hnrnp u) (scaffold attachment factor a) (saf-a). [swissprot;acc:q00839]	Ranked	237.109	254.667	1.07405
	histone h2b.s (h2b/s). [swissprot;acc:p57053]	Rooted	50.6084	55.2961	1.09263
	mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	Measured	9649.61	11053.5	1.14549
	solute carrier family 13, member 3 (sodium-dependent high-affinity dicarboxylate transporter 2) (na(+)/dicarboxylate cotransporter 3) (nadc-3) (hnadc3). [swissprot;acc:q8wwt9]	Squared	26867.3	32335.2	1.20352
483	histone h2b.d (h2b/d). [swissprot;acc:q99877]	Rooted	50.6084	55.2961	1.09263
	neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]	Measured	9649.61	11053.5	1.14549
	runt-related transcription factor 2 (core-binding factor, alpha 1 subunit) (cbf-alpha 1) (acute myeloid leukemia 3 protein) (oncogene aml-3) (polyomavirus enhancer binding protein 2 alpha a subunit) (pebp2-alpha a) (pea2-alpha a) (sl3-3 enhancer factor 1 alpha a subunit) (sl3/akv core-binding factor alpha a subunit) (osteoblast- specific transcription factor 2) (osf-2). [swissprot;acc:q13950]	Ranked	237.109	254.667	1.07405
	solute carrier family 13, member 2 (renal sodium/dicarboxylate cotransporter) (na(+)/dicarboxylate cotransporter 1) (nadc-1). [swissprot;acc:q13183]	Squared	26867.3	32335.2	1.20352
484	e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040]	Ranked	237.109	254.667	1.07405
	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	Rooted	50.6084	55.2961	1.09263
	neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297]	Measured	9649.61	11053.5	1.14549
	solute carrier family 13, member 4 (na+/sulfate cotransporter sut-1). [swissprot;acc:q9ukg4]	Squared	26867.2	32335	1.20351
485	60s ribosomal protein l18. [swissprot;acc:q07020]	Ranked	237.109	254.667	1.07405
	solute carrier family 13, member 1 (renal sodium/sulfate cotransporter) (na(+)/sulfate cotransporter) (hnasi-1). [swissprot;acc:q9bzw2]	Squared	26867.2	32335	1.20351
	sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0]	Measured	9649.61	11053.5	1.14549
	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	Rooted	50.6084	55.2961	1.09263
486	histone h2b.e (h2b/e). [swissprot;acc:q99879]
	mct-1 protein. [refseq;acc:nm_014060]	Ranked	226.313	243.03	1.07387
	secretory carrier-associated membrane protein 2. [swissprot;acc:o15127]	Squared	26865.9	32332.9	1.20349

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.