MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1891 to 1940 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
946	histone h4. [swissprot;acc:p02304]	no value	High confidence	227.765	219.902	1.03576
	vacuolar protein sorting-associated protein 45 (h-vps45) (hlvps45). [swissprot;acc:q9nrw7]	VPS45	Low confidence	204.752	199.775	1.02491
947	ad24 protein. [refseq;acc:nm_022451]	NOC3L		203.472	198.533	1.02488
	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	SORBS2	High confidence	212.51	205.191	1.03567
948	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	PBK	Low confidence	209.239	204.165	1.02485
	target of myb protein 1. [swissprot;acc:o60784]	TOM1	High confidence	217.254	209.824	1.03541
949	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	SRD5A1	Low confidence	204.147	199.196	1.02485
	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	no value	High confidence	217.253	209.826	1.0354
950	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	SRD5A2	Low confidence	204.147	199.196	1.02485
	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	ERCC5	High confidence	252.873	261.821	1.03539
951	dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	DTNBP1	Low confidence	203.779	198.841	1.02483
	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	TRIO	High confidence	217.253	209.827	1.03539
952	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	TOM1L2		217.252	209.83	1.03537
	vacuolar proton translocating atpase 116 kda subunit a isoform 2 (v-atpase 116-kda isoform a2) (tj6). [swissprot;acc:q9y487]	ATP6V0A2	Low confidence	190.738	186.118	1.02482
953	heat shock factor binding protein 1. [swissprot;acc:o75506]	no value		206.826	201.818	1.02481
	polymyositis/scleroderma autoantigen 2 (autoantigen pm/scl 2) (polymyositis/scleroderma autoantigen 100 kda) (pm/scl-100) (p100 polymyositis-scleroderma overlap syndrome associated autoantigen). [swissprot;acc:q01780]	EXOSC10	High confidence	198.494	205.466	1.03512
954	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	GSTZ1		267.447	276.773	1.03487
	vacuolar proton translocating atpase 116 kda subunit a isoform 3 (v- atpase 116-kda isoform a3) (osteoclastic proton pump 116 kda subunit) (oc-116 kda) (oc116) (t-cell immune regulator 1) (t cell immune response cdna7 protein) (tirc7). [swissprot;acc:q13488]	TCIRG1	Low confidence	190.801	186.183	1.0248
955	mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	MRPL27	High confidence	231.163	239.205	1.03479
	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	WASL	Low confidence	198.172	193.377	1.0248
956	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	DHX15		203.365	198.452	1.02476
	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	SORBS3	High confidence	211.812	204.732	1.03458
957	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	ARAF		129.913	134.399	1.03453
	transcription initiation factor tfiid 70 kda subunit (tafii-70) (tafii-80) (tafii80). [swissprot;acc:p49848]	TAF6	Low confidence	201.82	196.944	1.02476
958	probable serine/threonine protein kinase snf1lk (ec 2.7.1.-). [swissprot;acc:p57059]	SNF1LK		194.842	190.136	1.02475
	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	RAF1	High confidence	129.921	134.406	1.03452
959	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	no value		237.558	229.677	1.03431
	single-stranded dna-binding protein, mitochondrial precursor (mt-ssb) (mtssb) (pwp1-interacting protein 17). [swissprot;acc:q04837]	SSBP1	Low confidence	194.842	190.136	1.02475
960	sodium/iodide cotransporter (na(+)/i(-) cotransporter) (sodium-iodide symporter) (na+/i-symporter). [swissprot;acc:q92911]	SLC5A5		200.05	195.223	1.02473
	zuotin related factor-1 (m-phase phosphoprotein 11). [swissprot;acc:q99543]	ZRF1	High confidence	237.558	229.677	1.03431
961	phosphatidylinositol-binding clathrin assembly protein (clathrin assembly lymphoid myeloid leukemia protein). [swissprot;acc:q13492]	PICALM	Low confidence	203.548	198.638	1.02472
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	PPP2R5E	High confidence	130.066	134.527	1.0343
962	cyclin g2. [swissprot;acc:q16589]	CCNG2
	polymerase (dna directed), eta. [refseq;acc:nm_006502]	POLH	Low confidence	201.09	196.241	1.02471
963	cyclin g1 (cyclin g). [swissprot;acc:p51959]	CCNG1	High confidence	130.066	134.527	1.0343
	integral membrane protein 2b (transmembrane protein bri) [contains: abri/adan amyloid peptide]. [swissprot;acc:q9y287]	ITM2B	Low confidence	201.992	197.121	1.02471
964	integral membrane protein 2c (transmembrane protein bri3) (npd018). [swissprot;acc:q9nqx7]	ITM2C
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	PPP2R5A	High confidence	130.066	134.527	1.0343
965	integral membrane protein 2a (e25 protein). [swissprot;acc:o43736]	ITM2A	Low confidence	201.992	197.121	1.02471
	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	PARD6G	High confidence	211.987	204.964	1.03426
966	proliferation-associated protein 2g4 (cell cycle protein p38-2g4 homolog) (hg4-1). [swissprot;acc:q9uq80]	PA2G4	Low confidence	206.197	201.227	1.0247
	tubby protein homolog. [swissprot;acc:p50607]	TUB	High confidence	211.987	204.964	1.03426
967	lysine-deficient protein kinase 2; mitogen-activated protein kinase kinase kinase; serologically defined colon cancer antigen 43. [refseq;acc:nm_006648]	WNK2	Low confidence	204.782	199.848	1.02469
	protein kinase c, iota type (ec 2.7.1.37) (npkc-iota) (atypical protein kinase c-lamda/iota) (apkc-lambda/iota). [swissprot;acc:p41743]	PRKCI	High confidence	211.987	204.964	1.03426
968	numb protein homolog (h-numb) (protein s171). [swissprot;acc:p49757]	NUMB
	protein kinase, lysine deficient 4; putative protein kinase wnk4. [refseq;acc:nm_032387]	WNK4	Low confidence	204.782	199.848	1.02469
969	protein kinase, lysine deficient 3. [refseq;acc:nm_020922]	no value
	tbc1 domain family member 5. [swissprot;acc:q92609]	TBC1D5	High confidence	211.987	204.964	1.03426
970	protein kinase, lysine deficient 1; kinase deficient protein. [refseq;acc:nm_018979]	WNK1	Low confidence	204.782	199.848	1.02469
	tubby related protein 1 (tubby-like protein 1). [swissprot;acc:o00294]	TULP1	High confidence	211.987	204.964	1.03426

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.