MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1882 to 1931 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	network_comparison	green
941	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	ARID1A	Subtracted	212.437	7.354	205.083
942	grancalcin. [swissprot;acc:p28676]	GCA	Divided	212.442	1.03586	205.088
			Subtracted		7.354
943	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	PDCD6		212.437		205.083
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	SRI	Divided	212.442	1.03586	205.087
944	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	SORBS2	Subtracted	212.51	7.319	205.191
	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	PDCD6	Divided	212.437	1.03586	205.083
945	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	ARID1B		212.44		205.085
	dihydropyrimidine dehydrogenase [nadp+] precursor (ec 1.3.1.2) (dpd) (dhpdhase) (dihydrouracil dehydrogenase) (dihydrothymine dehydrogenase). [swissprot;acc:q12882]	no value	Subtracted	229.116	7.293	221.823
946	dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [swissprot;acc:q13409]	DYNC1I2		225.557	7.286	218.271
	histone h4. [swissprot;acc:p02304]	no value	Divided	227.765	1.03576	219.902
947	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	SORBS2		212.51	1.03567	205.191
	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	CLEC11A	Subtracted	177.776	7.277	170.499
948	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]	no value		225.167	7.245	217.922
	target of myb protein 1. [swissprot;acc:o60784]	TOM1	Divided	217.254	1.03541	209.824
949	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	no value		217.253	1.0354	209.826
	sprouty homolog 3 (spry-3). [swissprot;acc:o43610]	SPRY3	Subtracted	225.167	7.245	217.922
950	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	ERCC5	Divided	252.873	1.03539	261.821
	sprouty homolog 1 (spry-1) (fragment). [swissprot;acc:o43609]	SPRY1	Subtracted	225.167	7.245	217.922
951	sprouty homolog 2 (spry-2). [swissprot;acc:o43597]	SPRY2
	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	TRIO	Divided	217.253	1.03539	209.827
952	dynein intermediate chain 1, cytosolic (dh ic-1) (cytoplasmic dynein intermediate chain 1). [swissprot;acc:o14576]	DYNC1I1	Subtracted	225.448	7.216	218.232
	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	TOM1L2	Divided	217.252	1.03537	209.83
953	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	CLEC3A	Subtracted	178.033	7.213	170.82
	polymyositis/scleroderma autoantigen 2 (autoantigen pm/scl 2) (polymyositis/scleroderma autoantigen 100 kda) (pm/scl-100) (p100 polymyositis-scleroderma overlap syndrome associated autoantigen). [swissprot;acc:q01780]	EXOSC10	Divided	198.494	1.03512	205.466
954	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	GSTZ1		267.447	1.03487	276.773
	thioredoxin-like; pkc-interacting cousin of thioredoxin. [refseq;acc:nm_006541]	GLRX3	Subtracted	228.412	7.197	235.609
955	bai1-associated protein 1; ww domain-containing protein 3; atrophin-1 interacting protein 3. [refseq;acc:nm_004742]	MAGI1		221.73	7.176	228.906
	mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	MRPL27	Divided	231.163	1.03479	239.205
956	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	TCP1	Subtracted	135.379	7.154	128.225
	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]	SORBS3	Divided	211.812	1.03458	204.732
957	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	ARAF		129.913	1.03453	134.399
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	RGL1	Subtracted	168.592	7.14	161.452
958	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	RAF1	Divided	129.921	1.03452	134.406
	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	HTRA2	Subtracted	218.459	7.121	211.338
959	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	no value	Divided	237.558	1.03431	229.677
	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	HTRA4	Subtracted	218.461	7.118	211.343
960	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]	HTRA3		218.462	7.117	211.345
	zuotin related factor-1 (m-phase phosphoprotein 11). [swissprot;acc:q99543]	ZRF1	Divided	237.558	1.03431	229.677
961	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	HTRA1	Subtracted	218.468	7.111	211.357
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	PPP2R5E	Divided	130.066	1.0343	134.527
962	cyclin g2. [swissprot;acc:q16589]	CCNG2
	mitotic spindle assembly checkpoint protein mad2b (mad2-like 2) (hrev7). [swissprot;acc:q9ui95]	MAD2L2	Subtracted	219.656	7.109	212.547
963	cyclin g1 (cyclin g). [swissprot;acc:p51959]	CCNG1	Divided	130.066	1.0343	134.527
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	no value	Subtracted	219.656	7.109	212.547
964	nuclear pore complex protein nup88 (nucleoporin nup88) (88 kda nuclear pore complex protein). [swissprot;acc:q99567]	NUP88
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	PPP2R5A	Divided	130.066	1.0343	134.527
965	partitioning defective-6 homolog gamma (par-6 gamma) (par6d). [swissprot;acc:q9byg4]	PARD6G		211.987	1.03426	204.964
	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	CLEC3B	Subtracted	178.514	7.094	171.42
966	tubby protein homolog. [swissprot;acc:p50607]	TUB	Divided	211.987	1.03426	204.964

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.