MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1875 to 1924 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	network_comparison	green
enigma protein; lim domain protein. [refseq;acc:nm_005451]	1903	no value	Subtracted	219.753	2.179	217.574
	1929		Divided		1.01001
enoyl-coa hydratase, mitochondrial precursor (ec 4.2.1.17) (short chain enoyl-coa hydratase) (sceh) (enoyl-coa hydratase 1). [swissprot;acc:p30084]	1403	ECHS1		184.656	1.0212	180.823
	1512		Subtracted		3.833
enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	562	PRSS7		224.606	13.662	210.944
	577		Divided		1.06477
enthoprotin; epsin 4; clathrin interacting protein localized in the trans-golgi region. [refseq;acc:nm_014666]	1584	no value	Subtracted	221.426	3.476	224.902
	1612		Divided		1.0157
epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]	1112	EPS8	Subtracted	221.93	5.784	216.146
	1153		Divided		1.02676
epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	1109	EPS8L1	Subtracted	221.939	5.796	216.143
	1152		Divided		1.02682
epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	1118	EPS8L2	Subtracted	221.877	5.71	216.167
	1158		Divided		1.02641
epidermal growth factor receptor precursor (ec 2.7.1.112) (receptor protein-tyrosine kinase erbb-1). [swissprot;acc:p00533]	1960	EGFR	Subtracted	225.019	2.048	222.971
	2005		Divided		1.00919
epididymal secretory protein e1 precursor (niemann-pick disease type c2 protein) (epi-1) (he1) (epididymal secretory protein 14.6) (esp14.6). [swissprot;acc:q15668]	1339	NPC2		205.204	1.02239	200.71
	1368		Subtracted		4.494
epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	241	CDH1		241.892	24.068	265.96
	320		Divided		1.0995
epoxide hydrolase 1 (ec 3.3.2.3) (microsomal epoxide hydrolase) (epoxide hydratase). [swissprot;acc:p07099]	2446	EPHX1		182.272	1.00324	181.683
	2489		Subtracted		0.589
epsin 1; eh domain-binding mitotic phosphoprotein. [refseq;acc:nm_013333]	2411	EPN1		217.873	0.771	218.644
	2430		Divided		1.00354
epsin 2 isoform b; eps15 binding protein. [refseq;acc:nm_014964]	2542	EPN2	Subtracted	217.587	0.401	217.988
	2550		Divided		1.00184
epsin 3. [refseq;acc:nm_017957]	2280	EPN3	Subtracted	218.153	1.131	219.284
	2297		Divided		1.00518
ergic-53 protein precursor (er-golgi intermediate compartment 53 kda protein) (lectin, mannose-binding 1) (gp58) (intracellular mannose specific lectin mr60). [swissprot;acc:p49257]	3177	LMAN1		0.00001	1	0.00001
			Subtracted	0	0	0
ero1-like. [refseq;acc:nm_014584]	905	no value		217.168	7.961	209.207
	911		Divided		1.03805
erythroid differentiation and denucleation factor 1. [swissprot;acc:o60584]	1549	SLMO1	Subtracted	221.128	3.639	224.767
	1566		Divided		1.01646
erythroid differentiation-related factor 1. [refseq;acc:nm_015608]	3095	C10orf137		0.00001	1	0.00001
			Subtracted	0	0	0
espin. [refseq;acc:nm_031475]	1195	ESPNP		219.354	5.346	224.7
	1257		Divided		1.02437
esterase d (ec 3.1.1.1). [swissprot;acc:p10768]	2429	ESD		192.871	1.00355	193.555
	2446		Subtracted		0.684
estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061]	1028	HSD17B1		211.449	6.549	217.998
	1050		Divided		1.03097
estradiol 17 beta-dehydrogenase 4 (ec 1.1.1.62) (17-beta-hsd 4) (17-beta-hydroxysteroid dehydrogenase 4). [swissprot;acc:p51659]	1768	HSD17B4		185.276	1.01219	187.534
	1876		Subtracted		2.258
estrogen-related receptor gamma (estrogen receptor related protein 3) (err gamma-2). [swissprot;acc:o75454]	1042	no value	Divided	186.799	1.03132	181.127
	1123		Subtracted		5.672
ethanolamine kinase (ec 2.7.1.82) (eki). [swissprot;acc:q9hbu6]	2375	ETNK1		212.724	0.85	213.574
	2378		Divided		1.004
ethanolamine kinase-like protein eki2 (flj10761). [swissprot;acc:q9nvf9]	2374	ETNK2	Subtracted		0.85
	2377		Divided		1.004

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.