MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1862 to 1911 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
931	PFDN5	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	Subtracted	228.953	221.421	7.532
932	no value	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]
	MTRF1L	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	Divided	225.939	218.013	1.03636
933	BHLHB5	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]		159.165	164.951	1.03635
	EMG1	probable ribosome biogenesis protein nep1 (c2f protein). [swissprot;acc:q92979]	Subtracted	242.978	235.518	7.46
934	NOL6	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	Divided	242.024	233.544	1.03631
	TOM1	target of myb protein 1. [swissprot;acc:o60784]	Subtracted	217.254	209.824	7.43
935	no value	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]		217.253	209.826	7.427
		sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	Divided	232.473	224.372	1.03611
936		casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]
	TRIO	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	Subtracted	217.253	209.827	7.426
937	SF3A3	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	Divided	220.246	212.618	1.03588
	TOM1L2	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	Subtracted	217.252	209.83	7.422
938	SF3A1	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	Divided	220.246	212.618	1.03588
	SRI	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Subtracted	212.442	205.087	7.355
939	ARID1B	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]		212.44	205.085
	BRCA1	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	Divided	216.501	224.27	1.03588
940	CAPNS1	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]		212.442	205.088	1.03586
			Subtracted			7.354
941	ARID1A	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	Divided	212.437	205.083	1.03586
			Subtracted			7.354
942	GCA	grancalcin. [swissprot;acc:p28676]	Divided	212.442	205.088	1.03586
			Subtracted			7.354
943	PDCD6	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]		212.437	205.083
	SRI	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Divided	212.442	205.087	1.03586
944	PDCD6	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]		212.437	205.083
	SORBS2	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	Subtracted	212.51	205.191	7.319
945	no value	dihydropyrimidine dehydrogenase [nadp+] precursor (ec 1.3.1.2) (dpd) (dhpdhase) (dihydrouracil dehydrogenase) (dihydrothymine dehydrogenase). [swissprot;acc:q12882]		229.116	221.823	7.293
	ARID1B	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	Divided	212.44	205.085	1.03586
946	no value	histone h4. [swissprot;acc:p02304]		227.765	219.902	1.03576
	DYNC1I2	dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [swissprot;acc:q13409]	Subtracted	225.557	218.271	7.286
947	CLEC11A	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]		177.776	170.499	7.277
	SORBS2	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	Divided	212.51	205.191	1.03567
948	no value	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]	Subtracted	225.167	217.922	7.245
	TOM1	target of myb protein 1. [swissprot;acc:o60784]	Divided	217.254	209.824	1.03541
949	no value	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]		217.253	209.826	1.0354
	SPRY3	sprouty homolog 3 (spry-3). [swissprot;acc:o43610]	Subtracted	225.167	217.922	7.245
950	ERCC5	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	Divided	252.873	261.821	1.03539
	SPRY1	sprouty homolog 1 (spry-1) (fragment). [swissprot;acc:o43609]	Subtracted	225.167	217.922	7.245
951	SPRY2	sprouty homolog 2 (spry-2). [swissprot;acc:o43597]
	TRIO	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	Divided	217.253	209.827	1.03539
952	DYNC1I1	dynein intermediate chain 1, cytosolic (dh ic-1) (cytoplasmic dynein intermediate chain 1). [swissprot;acc:o14576]	Subtracted	225.448	218.232	7.216
	TOM1L2	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	Divided	217.252	209.83	1.03537
953	CLEC3A	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	Subtracted	178.033	170.82	7.213
	EXOSC10	polymyositis/scleroderma autoantigen 2 (autoantigen pm/scl 2) (polymyositis/scleroderma autoantigen 100 kda) (pm/scl-100) (p100 polymyositis-scleroderma overlap syndrome associated autoantigen). [swissprot;acc:q01780]	Divided	198.494	205.466	1.03512
954	GLRX3	thioredoxin-like; pkc-interacting cousin of thioredoxin. [refseq;acc:nm_006541]	Subtracted	228.412	235.609	7.197
	GSTZ1	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	Divided	267.447	276.773	1.03487
955	MAGI1	bai1-associated protein 1; ww domain-containing protein 3; atrophin-1 interacting protein 3. [refseq;acc:nm_004742]	Subtracted	221.73	228.906	7.176
	MRPL27	mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	Divided	231.163	239.205	1.03479
956	SORBS3	vinexin (sh3-containing adaptor molecule-1) (scam-1). [swissprot;acc:o60504]		211.812	204.732	1.03458

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.