MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1858 to 1907 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
929	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	MPDU1	Divided	225.955	218.015	1.03642
930	programmed cell death protein 5 (tfar19 protein) (tf-1 cell apoptosis related gene-19 protein). [swissprot;acc:o14737]	PDCD5	Subtracted	233.402	225.782	7.62
	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	PKM2	Divided	231.357	239.778	1.0364
931	ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]	BHLHB4		159.13	164.917	1.03637
	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	PFDN5	Subtracted	228.953	221.421	7.532
932	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	MTRF1L	Divided	225.939	218.013	1.03636
	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]	no value	Subtracted	228.953	221.421	7.532
933	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]	BHLHB5	Divided	159.165	164.951	1.03635
	probable ribosome biogenesis protein nep1 (c2f protein). [swissprot;acc:q92979]	EMG1	Subtracted	242.978	235.518	7.46
934	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	NOL6	Divided	242.024	233.544	1.03631
	target of myb protein 1. [swissprot;acc:o60784]	TOM1	Subtracted	217.254	209.824	7.43
935	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	no value		217.253	209.826	7.427
	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]		Divided	232.473	224.372	1.03611
936	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]
	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	TRIO	Subtracted	217.253	209.827	7.426
937	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	SF3A3	Divided	220.246	212.618	1.03588
	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	TOM1L2	Subtracted	217.252	209.83	7.422
938	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	SRI		212.442	205.087	7.355
	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	SF3A1	Divided	220.246	212.618	1.03588
939	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	BRCA1		216.501	224.27
	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	ARID1B	Subtracted	212.44	205.085	7.355
940	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	CAPNS1	Divided	212.442	205.088	1.03586
			Subtracted			7.354
941	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	ARID1A	Divided	212.437	205.083	1.03586
			Subtracted			7.354
942	grancalcin. [swissprot;acc:p28676]	GCA	Divided	212.442	205.088	1.03586
			Subtracted			7.354
943	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	PDCD6		212.437	205.083
	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	SRI	Divided	212.442	205.087	1.03586
944	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	SORBS2	Subtracted	212.51	205.191	7.319
	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	PDCD6	Divided	212.437	205.083	1.03586
945	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	ARID1B		212.44	205.085
	dihydropyrimidine dehydrogenase [nadp+] precursor (ec 1.3.1.2) (dpd) (dhpdhase) (dihydrouracil dehydrogenase) (dihydrothymine dehydrogenase). [swissprot;acc:q12882]	no value	Subtracted	229.116	221.823	7.293
946	dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [swissprot;acc:q13409]	DYNC1I2		225.557	218.271	7.286
	histone h4. [swissprot;acc:p02304]	no value	Divided	227.765	219.902	1.03576
947	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	SORBS2		212.51	205.191	1.03567
	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	CLEC11A	Subtracted	177.776	170.499	7.277
948	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]	no value		225.167	217.922	7.245
	target of myb protein 1. [swissprot;acc:o60784]	TOM1	Divided	217.254	209.824	1.03541
949	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	no value		217.253	209.826	1.0354
	sprouty homolog 3 (spry-3). [swissprot;acc:o43610]	SPRY3	Subtracted	225.167	217.922	7.245
950	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	ERCC5	Divided	252.873	261.821	1.03539
	sprouty homolog 1 (spry-1) (fragment). [swissprot;acc:o43609]	SPRY1	Subtracted	225.167	217.922	7.245
951	sprouty homolog 2 (spry-2). [swissprot;acc:o43597]	SPRY2
	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	TRIO	Divided	217.253	209.827	1.03539
952	dynein intermediate chain 1, cytosolic (dh ic-1) (cytoplasmic dynein intermediate chain 1). [swissprot;acc:o14576]	DYNC1I1	Subtracted	225.448	218.232	7.216
	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	TOM1L2	Divided	217.252	209.83	1.03537
953	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	CLEC3A	Subtracted	178.033	170.82	7.213
	polymyositis/scleroderma autoantigen 2 (autoantigen pm/scl 2) (polymyositis/scleroderma autoantigen 100 kda) (pm/scl-100) (p100 polymyositis-scleroderma overlap syndrome associated autoantigen). [swissprot;acc:q01780]	EXOSC10	Divided	198.494	205.466	1.03512
954	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	GSTZ1		267.447	276.773	1.03487

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.