MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1858 to 1907 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	network_comparison	green
465	ELL2	rna polymerase ii elongation factor ell2. [swissprot;acc:o00472]	Subtracted	Low confidence	198.618	6.751	205.369
	HS3ST6	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	Divided		207.812	1.03392	200.994
	ING2	inhibitor of growth family, member 1-like; inhibitor of growth 1-like. [refseq;acc:nm_001564]	Subtracted	High confidence	224.662	16.011	240.673
466	ADCY6	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]	Divided		248.152	1.07686	267.226
	CXorf9	chromosome x open reading frame 9; likely ortholog of mouse sh3 gene sly. [refseq;acc:nm_018990]	Subtracted	Low confidence	204.331	6.744	211.075
	HS3ST3A1	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	Divided		207.812	1.03392	200.994
	PRPF31	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	Subtracted	High confidence	225.661	16.01	209.651
467	ADCY5	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	Divided		248.152	1.07686	267.226
	DDX31	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	Subtracted		248.56	15.981	232.579
	HS3ST3B1	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	Divided	Low confidence	207.812	1.03392	200.994
	PRPF19	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	Subtracted		202.01	6.744	195.266
468	HS3ST2	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	Divided		207.812	1.03392	200.994
	LRRC15	leucine-rich repeat-containing protein 15 precursor (hlib). [swissprot;acc:q8tf66]		High confidence	248.152	1.07686	267.226
	POLR2L	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]	Subtracted		237.627	15.977	253.604
	TMOD4	skeletal muscle tropomodulin (sk-tmod) (tropomodulin 4). [swissprot;acc:q9nzq9]		Low confidence	209.136	6.658	202.478
469	DCPS	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	Divided		207.812	1.03392	200.994
	FEM1B	fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]		High confidence	248.152	1.07686	267.226
	KCNA2	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	Subtracted		226.789	15.971	210.818
	TMOD3	ubiquitous tropomodulin (u-tmod) (tropomodulin 3). [swissprot;acc:q9nyl9]		Low confidence	209.136	6.658	202.478
470	no value	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	Divided		198.464	1.03388	191.96
	ING1	inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537]	Subtracted	High confidence	224.535	15.941	240.476
	LRRC3	leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]	Divided		248.152	1.07686	267.226
	TMOD1	tropomodulin 1 (erythrocyte tropomodulin) (e-tmod). [swissprot;acc:p28289]	Subtracted	Low confidence	209.136	6.658	202.478
471	LAMC1	laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]	Divided	High confidence	248.152	1.07686	267.226
	RBM39	rna-binding region containing protein 2 (hepatocellular carcinoma protein 1) (splicing factor hcc1). [swissprot;acc:q14498]		Low confidence	208.29	1.0337	201.499
	SNX9	sorting nexin 9 (sh3 and px domain-containing protein 1) (sdp1 protein). [swissprot;acc:q9y5x1]	Subtracted		209.136	6.658	202.478
	ZNF622	zinc finger-like protein 9. [refseq;acc:nm_033414]		High confidence	250.942	15.938	235.004
472	PLRG1	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	Divided	Low confidence	201.847	1.03361	195.283
	SLC45A2	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]	Subtracted	High confidence	250.942	15.938	235.004
	SLC46A2	thymic stromal co-transporter. [refseq;acc:nm_033051]	Divided		248.152	1.07686	267.226
	TMOD2	neuronal tropomodulin (n-tmod) (tropomodulin 2). [swissprot;acc:q9nzr1]	Subtracted	Low confidence	209.136	6.658	202.478
473	no value	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]		High confidence	250.942	15.938	235.004
	EXOC1	exocyst complex component sec3 (bm-012). [swissprot;acc:q9nv70]	Divided	Low confidence	209.111	1.03346	202.34
	PRPF31	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]		High confidence	225.661	1.07637	209.651
	TNK2	activated p21cdc42hs kinase. [refseq;acc:nm_005781]	Subtracted	Low confidence	209.136	6.658	202.478
474	KCNA1	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]		High confidence	226.727	15.911	210.816
	KCNA2	potassium voltage-gated channel subfamily a member 2 (potassium channel kv1.2) (rbk2) (hbk5) (ngk1) (mk2) (hukiv). [swissprot;acc:p16389]	Divided		226.789	1.07576	210.818
	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]	Subtracted	Low confidence	201.429	6.653	194.776
	RRAGB	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Divided		171.213	1.0334	165.68
475	FUCA2	fucosidase, alpha-l- 2, plasma. [refseq;acc:nm_032020]			202.311	1.03337	195.778
	KCNA1	potassium voltage-gated channel subfamily a member 1 (potassium channel kv1.1) (huki) (hbk1). [swissprot;acc:q09470]		High confidence	226.727	1.07547	210.816
	MEMO1P	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	Subtracted		236.964	15.896	252.86
	SLC7A5	large neutral amino acids transporter small subunit 1 (l-type amino acid transporter 1) (4f2 light chain) (4f2 lc) (4f2lc) (cd98 light chain) (integral membrane protein e16) (hlat1). [swissprot;acc:q01650]		Low confidence	201.466	6.647	194.819
476	FUCA1	tissue alpha-l-fucosidase precursor (ec 3.2.1.51) (alpha-l-fucosidase i) (alpha-l-fucoside fucohydrolase). [swissprot;acc:p04066]	Divided		202.271	1.03336	195.742
	KCNA4	potassium voltage-gated channel subfamily a member 4 (potassium channel kv1.4) (hk1) (hpcn2) (hbk4) (hukii). [swissprot;acc:p22459]		High confidence	226.681	1.07527	210.814
			Subtracted			15.867
	PRRX1	paired mesoderm homeobox protein 1 (prx-1) (paired related homeobox protein 1) (homeobox protein phox1). [swissprot;acc:p54821]		Low confidence	194.41	6.626	201.036
477	ARHGEF7	rho guanine nucleotide exchange factor 7 (pak-interacting exchange factor beta) (beta-pix) (cool-1) (p85). [swissprot;acc:q14155]		High confidence	220.183	15.832	236.015
	HNRNPR	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	Divided	Low confidence	203.823	1.03333	197.249
	NIP7	saccharomyces cerevisiae nip7p homolog. [refseq;acc:nm_016101]		High confidence	251.926	1.0741	234.547

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.