MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	Network Comparison Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1858 to 1907 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Value Type	Network Comparison Type	description	red	green	network_comparison
233	CSRP3	Ranked	Divided	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	239.32	267.842	1.11918
	DLC1	Measured	Subtracted	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	9649.61	11053.5	1403.89
	HS3ST3A1	Squared		heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	41502.9	30836.8	10666.1
	MAGEB6B	Rooted	Divided	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	137.446	120.823	1.13758
	MAPKAPK2	Squared		map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	42411.6	55802.1	1.31573
	MYH1	Rooted	Subtracted	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	95.0526	85.3206	9.732
	MYH13	Measured	Divided	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	9035	7279.6	1.24114
234	no value	Rooted		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	137.446	120.823	1.13758
			Subtracted	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	95.0526	85.3206	9.732
	CHRAC1	Ranked	Divided	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	287.41	256.835	1.11905
	CHRNA6	Squared		neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	42411.6	55802.1	1.31573
	HS3ST3B1		Subtracted	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	41502.9	30836.8	10666.1
	MAPKAPK2	Measured		map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	9649.61	11053.5	1403.89
	RPS23	Ranked		40s ribosomal protein s23. [swissprot;acc:p39028]	243.944	268.195	24.251
	RPS6KC1	Measured	Divided	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	5181.2	6410.58	1.23728
235	no value			ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]
	CHRNA6		Subtracted	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	9649.61	11053.5	1403.89
	HS3ST2	Squared		heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	41502.9	30836.8	10666.1
	ISCU		Divided	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	42411.6	55802.1	1.31573
	MAGEA9	Rooted		melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	137.446	120.823	1.13758
	MRPS12	Ranked	Subtracted	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	243.944	268.195	24.251
	MYH7B	Rooted		dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	95.0526	85.3206	9.732
	PAH	Ranked	Divided	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	227.357	254.15	1.11785
236	DCPS	Squared	Subtracted	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	41502.9	30836.8	10666.1
	DUS1L	Ranked	Divided	pp3111 protein. [refseq;acc:nm_022156]	227.357	254.15	1.11785
	ISCU	Measured	Subtracted	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	9649.61	11053.5	1403.89
	MAGEA8	Rooted	Divided	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	137.446	120.823	1.13758
	MYH13		Subtracted	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	95.0526	85.3206	9.732
	RBBP7	Ranked		histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	252.644	228.42	24.224
	STARD13	Squared	Divided	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	42411.6	55802.1	1.31573
	TXNL4A	Measured		spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	4723.53	5828.46	1.23392
237	FIP1L1	Rooted	Subtracted	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	133.216	123.627	9.589
	LSM5	Measured	Divided	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	4567.04	5631.2	1.23301
	MAGEC1	Rooted		melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	137.446	120.823	1.13758
	MRPL3	Ranked	Subtracted	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	242.011	266.18	24.169
	MTX2	Squared		metaxin 2. [swissprot;acc:o75431]	41236	51807	10571
	STARD13	Measured		star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	9649.61	11053.5	1403.89
	STARD8	Squared	Divided	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	42411.6	55802.1	1.31573
	STX18	Ranked		syntaxin 18. [swissprot;acc:q9p2w9]	227.357	254.15	1.11785
238	no value			rd protein. [swissprot;acc:p18615]
	CHRNA2	Squared		neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	42411.6	55802.1	1.31573
	GORASP2		Subtracted	golgi reassembly stacking protein 2; golgi reassembly stacking protein 2, 55 kda. [refseq;acc:nm_015530]	42566.2	52985.3	10419.1
	MAGEA4	Rooted	Divided	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	137.446	120.823	1.13758
	MTA1	Ranked	Subtracted	metastasis-associated protein mta1. [swissprot;acc:q13330]	252.512	228.356	24.156
	PPP1R7	Measured	Divided	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	27642.5	22440.4	1.23182
	SNRPD3	Rooted	Subtracted	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	56.3709	65.8949	9.524
	STARD8	Measured		star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	9649.61	11053.5	1403.89
239	no value	Rooted	Divided	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	137.446	120.823	1.13758
	CHRNA2	Measured	Subtracted	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	9649.61	11053.5	1403.89
	CPA6		Divided	carboxypeptidase b precursor. [refseq;acc:nm_020361]	7711.38	6265.8	1.23071

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.