MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Network Comparison Type	Gene	Value Type	Hugo	Interaction Map	red	Filtered	green	network_comparison

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Showing element 1858 to 1907 of 66312 in total

Filtered  : 1

description	Rank	Network Comparison Type	Value Type	Hugo	Interaction Map	red	green	network_comparison
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6pf-2-k/fru- 2,6-p2ase liver isozyme) [includes: 6-phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:p16118]	160	Subtracted	Squared	PFKFB1	Low confidence	53380.6	47490	5890.6
	3865	Divided	Ranked			194.792	197.306	1.01291
	3905	Subtracted						2.514
	4269		Measured			8966.91	8797.85	169.06
	4457	Divided						1.01922
	5002	Subtracted	Rooted			76.3109	76.4154	0.1045
	5005	Divided						1.00137
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6pf-2-k/fru- 2,6-p2ase heart-type isozyme) (pfk-2/fbpase-2) [includes: 6- phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:o60825]	155		Squared	PFKFB2		53380.6	47490	1.12404
	162	Subtracted						5890.6
	3867	Divided	Ranked			194.792	197.306	1.01291
	3907	Subtracted						2.514
	4271		Measured			8966.91	8797.85	169.06
	4459	Divided						1.01922
	5004	Subtracted	Rooted			76.3109	76.4154	0.1045
	5007	Divided						1.00137
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6pf-2-k/fru- 2,6-p2ase brain/placenta-type isozyme) (ipfk-2) [includes: 6- phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:q16875]	152		Squared	PFKFB3		53380.6	47490	1.12404
	159	Subtracted						5890.6
	3864	Divided	Ranked			194.792	197.306	1.01291
	3904	Subtracted						2.514
	4268		Measured			8966.91	8797.85	169.06
	4456	Divided						1.01922
	5001	Subtracted	Rooted			76.3109	76.4154	0.1045
	5004	Divided						1.00137
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6pf-2-k/fru- 2,6-p2ase testis-type isozyme) [includes: 6-phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:q16877]	156		Squared	PFKFB4		53380.6	47490	1.12404
	163	Subtracted						5890.6
	3868	Divided	Ranked			194.792	197.306	1.01291
	3908	Subtracted						2.514
	4272		Measured			8966.91	8797.85	169.06
	4460	Divided						1.01922
	5005	Subtracted	Rooted			76.3109	76.4154	0.1045
	5008	Divided						1.00137
6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858]	642		Squared	PFKL	High confidence	16123.9	19009.7	1.17898
	764		Measured			4250.18	4729.12	1.11269
	1268	Subtracted						478.94
	1325		Squared			16123.9	19009.7	2885.8
	1364				Low confidence	46493	44527.5	1965.5
	1389	Divided						1.04414
	1733	Subtracted	Ranked		High confidence	240.32	243.085	2.765
	1822	Divided						1.01151
	1905		Rooted			52.8713	54.4076	1.02906
	2124	Subtracted						1.5363
	2734		Ranked		Low confidence	200.929	197.479	3.45
	2739	Divided						1.01747
	2747	Subtracted	Rooted			72.5222	74.8922	2.37
	2839	Divided						1.03268
	3063	Subtracted	Measured			8126.59	8347.5	220.91
	3242	Divided						1.02718
6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [swissprot;acc:p08237]	643		Squared	PFKM	High confidence	16126.5	19012.6	1.17897
	763		Measured			4250.54	4729.67	1.11272
	1265	Subtracted						479.13

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.