MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	Network Comparison Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1832 to 1881 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	red	green	network_comparison
916	HAO2	Divided	hydroxyacid oxidase 2 (ec 1.1.3.15) (haox2) ((s)-2-hydroxy-acid oxidase, peroxisomal) (long chain alpha-hydroxy acid oxidase) (long- chain l-2-hydroxy acid oxidase). [swissprot;acc:q9nyq3]	232.512	241.288	1.03774
917	CDC73		parafibromin. [refseq;acc:nm_024529]	239.704	230.991	1.03772
	DNASE2B	Subtracted	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	86.7483	78.8995	7.8488
918	IMMP2L		imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	217.942	210.139	7.803
	SORBS1	Divided	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	212.952	205.292	1.03731
919	no value	Subtracted	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	217.942	210.139	7.803
	MDN1	Divided	midasin (midas-containing protein). [swissprot;acc:q9nu22]	237.218	228.698	1.03725
920	BRCA1	Subtracted	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	216.501	224.27	7.769
	DEAF1	Divided	deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398]	236.741	245.547	1.0372
921	RIOK1		rio kinase 1 isoform 1; ad034 protein. [refseq;acc:nm_031480]
	WDR46	Subtracted	wd-repeat protein bing4. [swissprot;acc:o15213]	243.227	235.475	7.752
922	MARK1	Divided	map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]	236.741	245.547	1.0372
	PEF1	Subtracted	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	215.665	207.942	7.723
923	HPRT1		hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	193.114	185.412	7.702
	MARK2	Divided	map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]	236.741	245.547	1.0372
924	no value	Subtracted	sh2 domain binding protein 1; tpr-containing, sh2-binding phosphoprotein. [refseq;acc:nm_014633]	238.725	231.059	7.666
	SPO11	Divided	meiotic recombination protein spo11. [swissprot;acc:q9y5k1]	236.741	245.547	1.0372
925	HEATR1	Subtracted	protein bap28. [swissprot;acc:q9h583]	244.312	236.647	7.665
	PEF1	Divided	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	215.665	207.942	1.03714
926	IMMP2L		imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	217.942	210.139	1.03713
	SORBS1	Subtracted	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	212.952	205.292	7.66
927	no value	Divided	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	217.942	210.139	1.03713
	SF3A3	Subtracted	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	220.246	212.618	7.628
928	MTRF1	Divided	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	225.976	218.017	1.03651
	SF3A1	Subtracted	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	220.246	212.618	7.628
929	AATF		apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	243.045	235.422	7.623
	MPDU1	Divided	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	225.955	218.015	1.03642
930	PDCD5	Subtracted	programmed cell death protein 5 (tfar19 protein) (tf-1 cell apoptosis related gene-19 protein). [swissprot;acc:o14737]	233.402	225.782	7.62
	PKM2	Divided	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	231.357	239.778	1.0364
931	BHLHB4		ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]	159.13	164.917	1.03637
	PFDN5	Subtracted	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	228.953	221.421	7.532
932	no value		prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]
	MTRF1L	Divided	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	225.939	218.013	1.03636
933	BHLHB5		basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]	159.165	164.951	1.03635
	EMG1	Subtracted	probable ribosome biogenesis protein nep1 (c2f protein). [swissprot;acc:q92979]	242.978	235.518	7.46
934	NOL6	Divided	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	242.024	233.544	1.03631
	TOM1	Subtracted	target of myb protein 1. [swissprot;acc:o60784]	217.254	209.824	7.43
935	no value	Divided	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	232.473	224.372	1.03611
		Subtracted	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	217.253	209.826	7.427
936		Divided	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]	232.473	224.372	1.03611
	TRIO	Subtracted	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	217.253	209.827	7.426
937	SF3A3	Divided	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	220.246	212.618	1.03588
	TOM1L2	Subtracted	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	217.252	209.83	7.422
938	SF3A1	Divided	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	220.246	212.618	1.03588
	SRI	Subtracted	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	212.442	205.087	7.355
939	ARID1B		brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	212.44	205.085
	BRCA1	Divided	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	216.501	224.27	1.03588
940	CAPNS1		calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	212.442	205.088	1.03586
		Subtracted				7.354
941	ARID1A	Divided	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	212.437	205.083	1.03586

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.