MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1832 to 1881 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
916	OCA2	p protein (melanocyte-specific transporter protein). [swissprot;acc:q04671]	Low confidence	201.059	196.129	1.02514
917	CDC73	parafibromin. [refseq;acc:nm_024529]	High confidence	239.704	230.991	1.03772
	LIN7A	lin-7 homolog a; vertebrate lin7 homolog 1; tax interaction protein 33; mammalian lin-7 1. [refseq;acc:nm_004664]	Low confidence	207.884	202.788	1.02513
918	SORBS1	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	High confidence	212.952	205.292	1.03731
	SORT1	sortilin precursor (glycoprotein 95) (gp95) (neurotensin receptor 3) (nt3) (100 kda nt receptor). [swissprot;acc:q99523]	Low confidence	198.577	193.713	1.02511
919	MDN1	midasin (midas-containing protein). [swissprot;acc:q9nu22]	High confidence	237.218	228.698	1.03725
	PPP3CB	serine/threonine protein phosphatase 2b catalytic subunit, beta isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, beta isoform) (cam-prp catalytic subunit). [swissprot;acc:p16299]	Low confidence	201.056	196.132	1.02511
920	DEAF1	deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398]	High confidence	236.741	245.547	1.0372
	UBC	ubiquitin. [swissprot;acc:p02248]	Low confidence	193.011	188.286	1.02509
921	PPP3CC	serine/threonine protein phosphatase 2b catalytic subunit, gamma isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, gamma isoform) (calcineurin, testis-specific catalytic subunit) (cam-prp catalytic subunit). [swissprot;acc:p48454]		201.054	196.135	1.02508
	RIOK1	rio kinase 1 isoform 1; ad034 protein. [refseq;acc:nm_031480]	High confidence	236.741	245.547	1.0372
922	GPKOW	t54 protein. [swissprot;acc:q92917]	Low confidence	204.822	199.81	1.02508
	MARK1	map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]	High confidence	236.741	245.547	1.0372
923	LIN7B	lin-7 homolog b; lin-7b protein; likely ortholog of mouse lin-7b; mammalian lin-7 protein 2; likely orholog of mouse lin 7 homolog b (c. elegans). [refseq;acc:nm_022165]	Low confidence	207.877	202.795	1.02506
	MARK2	map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]	High confidence	236.741	245.547	1.0372
924	HYAL3	interferon-related developmental regulator 2 (skmc15 protein). [swissprot;acc:q12894]	Low confidence	203.086	198.123	1.02505
	SPO11	meiotic recombination protein spo11. [swissprot;acc:q9y5k1]	High confidence	236.741	245.547	1.0372
925	FARSA	phenylalanyl-trna synthetase alpha chain (ec 6.1.1.20) (phenylalanine- -trna ligase alpha chain) (phers) (cml33). [swissprot;acc:q9y285]	Low confidence	201.128	196.213	1.02505
	PEF1	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	High confidence	215.665	207.942	1.03714
926	GLUL	glutamine synthetase (ec 6.3.1.2) (glutamate--ammonia ligase). [swissprot;acc:p15104]	Low confidence	201.442	196.519	1.02505
	IMMP2L	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	High confidence	217.942	210.139	1.03713
927	no value	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]
	CUTL1	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	Low confidence	198.264	193.42	1.02504
928	ETV6	transcription factor etv6 (ets-related protein tel1) (tel) (ets translocation variant 6). [swissprot;acc:p41212]		205.137	200.128	1.02503
	MTRF1	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	High confidence	225.976	218.017	1.03651
929	CUTL2	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	Low confidence	198.26	193.418	1.02503
	MPDU1	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	High confidence	225.955	218.015	1.03642
930	C19orf56	protein cgi-140 (protein ptd008) (my006 protein). [swissprot;acc:q9y284]	Low confidence	205.137	200.128	1.02503
	PKM2	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	High confidence	231.357	239.778	1.0364
931	BHLHB4	ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]		159.13	164.917	1.03637
	ETV7	transcription factor tel-2 (ets-related protein tel2) (tel related ets factor). [swissprot;acc:q9y603]	Low confidence	205.137	200.128	1.02503
932	FBP1	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]		190.502	185.852	1.02502
	MTRF1L	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	High confidence	225.939	218.013	1.03636
933	BHLHB5	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]		159.165	164.951	1.03635
	SEL1L2	dj842g6.2 (novel protein imilar to sel1l (sel-1 (suppressor of lin-12, c.elegans)-like)) (fragment). [sptrembl;acc:q9ugd3]	Low confidence	190.447	185.802	1.025
934	NOL6	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	High confidence	242.024	233.544	1.03631
	SEL1L	sel-1 homolog precursor (suppressor of lin-12-like protein) (sel-1l). [swissprot;acc:q9ubv2]	Low confidence	190.447	185.803	1.02499
935	no value	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	High confidence	232.473	224.372	1.03611
	ICT1	immature colon carcinoma transcript 1 (digestion substraction 1) (ds- 1). [swissprot;acc:q14197]	Low confidence	200.801	195.908	1.02498
936	no value	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]	High confidence	232.473	224.372	1.03611
	FBP2	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	Low confidence	190.386	185.747	1.02497
937	no value	spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]		194.236	189.504
	SF3A3	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	High confidence	220.246	212.618	1.03588
938	SF3A1	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]
	SNAP91	clathrin coat assembly protein ap180 (clathrin coat associated protein ap180) (91 kda synaptosomal-associated protein). [swissprot;acc:o60641]	Low confidence	203.609	198.648	1.02497
939	BRCA1	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	High confidence	216.501	224.27	1.03588
	SGCD	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	Low confidence	206.817	201.78	1.02496
940	CAPNS1	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	High confidence	212.442	205.088	1.03586
	VPS29	vacuolar protein sorting 29 (vesicle protein sorting 29) (hvps29) (mds007) (pep11) (dc7/dc15). [swissprot;acc:q9ubq0]	Low confidence	202.747	197.81	1.02496
941	ARID1A	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	High confidence	212.437	205.083	1.03586

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.