MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1832 to 1881 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	red	green	network_comparison
916	Subtracted	no value	histone h4. [swissprot;acc:p02304]	227.765	219.902	7.863
917	Divided	CDC73	parafibromin. [refseq;acc:nm_024529]	239.704	230.991	1.03772
	Subtracted	DNASE2B	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	86.7483	78.8995	7.8488
918	Divided	SORBS1	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	212.952	205.292	1.03731
	Subtracted	IMMP2L	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	217.942	210.139	7.803
919	Divided	MDN1	midasin (midas-containing protein). [swissprot;acc:q9nu22]	237.218	228.698	1.03725
	Subtracted	no value	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	217.942	210.139	7.803
920	Divided	DEAF1	deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398]	236.741	245.547	1.0372
	Subtracted	BRCA1	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	216.501	224.27	7.769
921	Divided	RIOK1	rio kinase 1 isoform 1; ad034 protein. [refseq;acc:nm_031480]	236.741	245.547	1.0372
	Subtracted	WDR46	wd-repeat protein bing4. [swissprot;acc:o15213]	243.227	235.475	7.752
922	Divided	MARK1	map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]	236.741	245.547	1.0372
	Subtracted	PEF1	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	215.665	207.942	7.723
923	Divided	MARK2	map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]	236.741	245.547	1.0372
	Subtracted	HPRT1	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	193.114	185.412	7.702
924	Divided	SPO11	meiotic recombination protein spo11. [swissprot;acc:q9y5k1]	236.741	245.547	1.0372
	Subtracted	no value	sh2 domain binding protein 1; tpr-containing, sh2-binding phosphoprotein. [refseq;acc:nm_014633]	238.725	231.059	7.666
925	Divided	PEF1	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	215.665	207.942	1.03714
	Subtracted	HEATR1	protein bap28. [swissprot;acc:q9h583]	244.312	236.647	7.665
926	Divided	IMMP2L	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	217.942	210.139	1.03713
	Subtracted	SORBS1	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	212.952	205.292	7.66
927	Divided	no value	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	217.942	210.139	1.03713
	Subtracted	SF3A3	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	220.246	212.618	7.628
928	Divided	MTRF1	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	225.976	218.017	1.03651
	Subtracted	SF3A1	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	220.246	212.618	7.628
929	Divided	MPDU1	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	225.955	218.015	1.03642
	Subtracted	AATF	apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	243.045	235.422	7.623
930	Divided	PKM2	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	231.357	239.778	1.0364
	Subtracted	PDCD5	programmed cell death protein 5 (tfar19 protein) (tf-1 cell apoptosis related gene-19 protein). [swissprot;acc:o14737]	233.402	225.782	7.62
931	Divided	BHLHB4	ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]	159.13	164.917	1.03637
	Subtracted	PFDN5	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	228.953	221.421	7.532
932	Divided	MTRF1L	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	225.939	218.013	1.03636
	Subtracted	no value	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]	228.953	221.421	7.532
933	Divided	BHLHB5	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]	159.165	164.951	1.03635
	Subtracted	EMG1	probable ribosome biogenesis protein nep1 (c2f protein). [swissprot;acc:q92979]	242.978	235.518	7.46
934	Divided	NOL6	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	242.024	233.544	1.03631
	Subtracted	TOM1	target of myb protein 1. [swissprot;acc:o60784]	217.254	209.824	7.43
935	Divided	no value	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	232.473	224.372	1.03611
	Subtracted		huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	217.253	209.826	7.427
936	Divided		casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]	232.473	224.372	1.03611
	Subtracted	TRIO	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	217.253	209.827	7.426
937	Divided	SF3A3	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	220.246	212.618	1.03588
	Subtracted	TOM1L2	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	217.252	209.83	7.422
938	Divided	SF3A1	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	220.246	212.618	1.03588
	Subtracted	SRI	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	212.442	205.087	7.355
939	Divided	BRCA1	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	216.501	224.27	1.03588
	Subtracted	ARID1B	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	212.44	205.085	7.355
940	Divided	CAPNS1	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	212.442	205.088	1.03586
	Subtracted					7.354
941	Divided	ARID1A	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	212.437	205.083	1.03586

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.