MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1832 to 1881 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
916	hydroxyacid oxidase 2 (ec 1.1.3.15) (haox2) ((s)-2-hydroxy-acid oxidase, peroxisomal) (long chain alpha-hydroxy acid oxidase) (long- chain l-2-hydroxy acid oxidase). [swissprot;acc:q9nyq3]	HAO2	Divided	232.512	241.288	1.03774
917	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	DNASE2B	Subtracted	86.7483	78.8995	7.8488
	parafibromin. [refseq;acc:nm_024529]	CDC73	Divided	239.704	230.991	1.03772
918	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	IMMP2L	Subtracted	217.942	210.139	7.803
	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	SORBS1	Divided	212.952	205.292	1.03731
919	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	no value	Subtracted	217.942	210.139	7.803
	midasin (midas-containing protein). [swissprot;acc:q9nu22]	MDN1	Divided	237.218	228.698	1.03725
920	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	BRCA1	Subtracted	216.501	224.27	7.769
	deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398]	DEAF1	Divided	236.741	245.547	1.0372
921	rio kinase 1 isoform 1; ad034 protein. [refseq;acc:nm_031480]	RIOK1
	wd-repeat protein bing4. [swissprot;acc:o15213]	WDR46	Subtracted	243.227	235.475	7.752
922	map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]	MARK1	Divided	236.741	245.547	1.0372
	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	PEF1	Subtracted	215.665	207.942	7.723
923	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	HPRT1		193.114	185.412	7.702
	map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]	MARK2	Divided	236.741	245.547	1.0372
924	meiotic recombination protein spo11. [swissprot;acc:q9y5k1]	SPO11
	sh2 domain binding protein 1; tpr-containing, sh2-binding phosphoprotein. [refseq;acc:nm_014633]	no value	Subtracted	238.725	231.059	7.666
925	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	PEF1	Divided	215.665	207.942	1.03714
	protein bap28. [swissprot;acc:q9h583]	HEATR1	Subtracted	244.312	236.647	7.665
926	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	IMMP2L	Divided	217.942	210.139	1.03713
	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	SORBS1	Subtracted	212.952	205.292	7.66
927	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	no value	Divided	217.942	210.139	1.03713
	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	SF3A3	Subtracted	220.246	212.618	7.628
928	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	MTRF1	Divided	225.976	218.017	1.03651
	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	SF3A1	Subtracted	220.246	212.618	7.628
929	apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	AATF		243.045	235.422	7.623
	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	MPDU1	Divided	225.955	218.015	1.03642
930	programmed cell death protein 5 (tfar19 protein) (tf-1 cell apoptosis related gene-19 protein). [swissprot;acc:o14737]	PDCD5	Subtracted	233.402	225.782	7.62
	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	PKM2	Divided	231.357	239.778	1.0364
931	ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]	BHLHB4		159.13	164.917	1.03637
	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	PFDN5	Subtracted	228.953	221.421	7.532
932	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	MTRF1L	Divided	225.939	218.013	1.03636
	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]	no value	Subtracted	228.953	221.421	7.532
933	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]	BHLHB5	Divided	159.165	164.951	1.03635
	probable ribosome biogenesis protein nep1 (c2f protein). [swissprot;acc:q92979]	EMG1	Subtracted	242.978	235.518	7.46
934	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	NOL6	Divided	242.024	233.544	1.03631
	target of myb protein 1. [swissprot;acc:o60784]	TOM1	Subtracted	217.254	209.824	7.43
935	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]	no value		217.253	209.826	7.427
	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]		Divided	232.473	224.372	1.03611
936	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]
	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	TRIO	Subtracted	217.253	209.827	7.426
937	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	SF3A3	Divided	220.246	212.618	1.03588
	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	TOM1L2	Subtracted	217.252	209.83	7.422
938	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	SRI		212.442	205.087	7.355
	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	SF3A1	Divided	220.246	212.618	1.03588
939	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	BRCA1		216.501	224.27
	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]	ARID1B	Subtracted	212.44	205.085	7.355
940	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	CAPNS1	Divided	212.442	205.088	1.03586
			Subtracted			7.354
941	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]	ARID1A	Divided	212.437	205.083	1.03586

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.