MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1830 to 1879 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Value Type	Network Comparison Type	red	green	network_comparison
adp-ribosylation factor gtpase activating protein 1 (adp-ribosylation factor 1 gtpase activating protein) (arf1 gap) (arf1-directed gtpase- activating protein) (gap protein). [swissprot;acc:q8n6t3]	1459	ARFGAP1	Rooted	Divided	68.657	71.3161	1.03873
	2156		Ranked		200.063	198.71	1.00681
	2219			Subtracted			1.353
adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	1563	ARFGAP3	Squared		25629.5	28203.8	2574.3
	1761			Divided			1.10044
	1830		Measured		5633.44	5997	1.06454
	1898			Subtracted			363.56
	2116		Ranked		221.248	222.788	1.54
	2137			Divided			1.00696
	2181		Rooted		60.8609	62.2517	1.02285
	2228			Subtracted			1.3908
adp-ribosylation factor-like protein 1. [swissprot;acc:p40616]	1383	ARL1	Squared		28122.9	30941.9	2819
	1573		Measured		6035.6	6464.5	428.9
	1619			Divided			1.07106
	1773		Squared		28122.9	30941.9	1.10024
	1868		Rooted		63.2302	65.1018	1.0296
	1873			Subtracted			1.8716
	2613		Ranked	Divided	215.497	215.799	1.0014
	2623			Subtracted			0.302
adp-ribosylation factor-like protein 3. [swissprot;acc:p36405]	1342	ARL3	Squared		27060.6	29916.8	2856.2
	1530		Measured		5916.05	6350.53	434.48
	1534			Divided			1.07344
	1689		Squared		27060.6	29916.8	1.10555
	1859		Rooted		62.7784	64.64	1.02965
	1879			Subtracted			1.8616
	2517		Ranked		215.835	216.341	0.506
	2520			Divided			1.00234
adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]	821	ARL4A	Measured	Subtracted	5912.84	6517.69	604.85
			Squared		26499.7	30423.6	3923.9
	883		Measured	Divided	5912.84	6517.69	1.10229
	987		Rooted	Subtracted	62.4582	65.9096	3.4514
	988			Divided			1.05526
	1022		Squared		26499.7	30423.6	1.14807
	1163		Ranked	Subtracted	218.402	212.904	5.498
	1188			Divided			1.02582
adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	819	no value	Measured	Subtracted	5912.84	6517.69	604.85
			Squared		26499.7	30423.6	3923.9
	881		Measured	Divided	5912.84	6517.69	1.10229
	985		Rooted	Subtracted	62.4582	65.9096	3.4514
	986			Divided			1.05526
	1020		Squared		26499.7	30423.6	1.14807
	1161		Ranked	Subtracted	218.402	212.904	5.498
	1186			Divided			1.02582
adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]	239	FDX1	Squared	Subtracted	36563.7	46971.1	10407.4
	272			Divided			1.28464
	298		Measured	Subtracted	8268.19	9405.85	1137.66
	548			Divided			1.13759
	617		Rooted	Subtracted	76.0455	80.7777	4.7322
	862			Divided			1.06223
	1105		Ranked		191.139	185.882	1.02828

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.