MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 182 to 231 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Value Type	description	Network Comparison Type	red	green	network_comparison
23	MRPS17	Ranked	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Divided	58	44	1.31818
	NEUROD2	Squared	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]		143.692	457.521	3.18404
	TMEM132A	Measured	gbp protein isoform a. [refseq;acc:nm_017870]		699.76	1894.39	2.7072
24	ATG4B	Rooted	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Subtracted	153.548	133.153	20.395
	CHD3	Squared	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	Divided	143.692	457.521	3.18404
	GNG8	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]		40.336	24.2941	1.66032
	MAGEA11	Measured	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Subtracted	23693.7	18263	5430.7
	MAGEC1	Squared	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]		219048	129762	89286
	PANK1	Ranked	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Divided	58	44	1.31818
	PPP1R14D		protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Subtracted	322	253	69
	PRKRAP1	Measured	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Divided	950.561	2108.52	2.21818
25	no value		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		1833.01	892.67	2.0534
	CDK2AP2	Squared	doc-1 related protein (doc-1r). [swissprot;acc:o75956]		143.692	457.521	3.18404
	FCN2	Ranked	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	Subtracted	322	253	69
	GNG5	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	Divided	40.3361	24.295	1.66026
	MAGEA2B	Measured	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Subtracted	23693.7	18263	5430.7
	MAGEA4	Squared	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]		219048	129762	89286
	MYO5B	Rooted	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]		146.94	167.046	20.106
	PANK2	Ranked	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Divided	58	44	1.31818
26	no value	Measured	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Subtracted	23693.7	18263	5430.7
		Ranked	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]		322	253	69
		Squared	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]		219048	129762	89286
	GNG10	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	Divided	40.3362	24.2954	1.66024
	GNG12	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]		1833.01	892.67	2.0534
	MYO5C	Rooted	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Subtracted	146.94	167.046	20.106
	NEUROD6	Squared	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	Divided	143.692	457.521	3.18404
	PANK3	Ranked	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]		58	44	1.31818
27	no value	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		40.3364	24.2968	1.66015
			myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Subtracted	146.94	167.046	20.106
	GNAQ	Ranked	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]		267.136	336.077	68.941
	GNG4	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	Divided	1834.33	895.134	2.04922
	MAGEA10	Squared	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Subtracted	219048	129762	89286
	MAGEA6	Measured	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]		23693.7	18263	5430.7
	NEUROD1	Squared	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	Divided	143.692	457.521	3.18404
	SLC25A43	Ranked	mitochondrial solute carrier protein. [refseq;acc:nm_145305]		58	44	1.31818
28	ATF3		cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		201.949	153.671	1.31416
	GABARAP	Rooted	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Subtracted	149.165	129.699	19.466
	GNA11	Ranked	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]		267.136	336.077	68.941
	GNG11	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Divided	40.3372	24.3043	1.65967
	GNG3	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]		1834.36	895.194	2.04912
	MAGEB4	Squared	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Subtracted	219048	129762	89286
	NDN	Measured	necdin. [swissprot;acc:q99608]		23693.7	18263	5430.7
	NEUROD4	Squared	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	Divided	143.692	457.521	3.18404
29	CHD5		chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]
	GNAZ	Ranked	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Subtracted	267.139	336.075	68.936
	GNG8	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Divided	1834.52	895.507	2.04858
	MAGED1		melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Subtracted	23693.7	18263	5430.7
	MAGED2	Squared	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]		219048	129762	89286
	PPP1R14A	Rooted	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Divided	26.0288	43.1914	1.65937
	PPP2R2D	Ranked	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]		187.458	243.678	1.29991

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.