MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 182 to 231 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
91	transcription factor lbx1. [swissprot;acc:p52954]	LBX1	Subtracted	249.663	298.263	48.6
92	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	MAGEF1	Divided	88.2482	110.265	1.24949
	mosaic protein lgn. [swissprot;acc:p81274]	GPSM2	Subtracted	249.663	298.263	48.6
93	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	MAGEB6B	Divided	88.2482	110.265	1.24949
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	RGS17	Subtracted	249.663	298.263	48.6
94	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	GNAO1
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	no value	Divided	88.2482	110.265	1.24949
95	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	MAGEA9
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	RAP1GAP	Subtracted	249.663	298.263	48.6
96	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	ATF3		201.949	153.671	48.278
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	MAGEA8	Divided	88.2482	110.265	1.24949
97	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	APBA1	Subtracted	271.752	225.68	46.072
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	MAGEC1	Divided	88.2482	110.265	1.24949
98	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	MAGEA4
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	FOS	Subtracted	204.641	160.957	43.684
99	jun dimerization protein. [refseq;acc:nm_130469]	no value
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]		Divided	88.2482	110.265	1.24949
100	fos-related antigen 2. [swissprot;acc:p15408]	FOSL2	Subtracted	204.641	161.046	43.595
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	MAGEA10	Divided	88.2482	110.265	1.24949
101	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	MAGEB4
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	FOSB	Subtracted	204.641	161.051	43.59
102	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	FOSL1		204.642	161.068	43.574
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	MAGED2	Divided	88.2482	110.265	1.24949
103	transcription factor jun-b. [swissprot;acc:p17275]	JUNB	Subtracted	201.144	158.868	42.276
	trophinin. [swissprot;acc:q12816]	TRO	Divided	88.2482	110.265	1.24949
104	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	HOMER2		252.371	202.016	1.24926
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	TARDBP	Subtracted	256.228	298.438	42.21
105	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	GNB1	Divided	266.716	333.165	1.24914
	transcription factor jun-d. [swissprot;acc:p17535]	JUND	Subtracted	200.941	158.941	42
106	nostrin. [refseq;acc:nm_052946]	NOSTRIN		209.299	249.187	39.888
	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	COQ7	Divided	252.329	202.004	1.24913
107	eap30 subunit of ell complex. [refseq;acc:nm_007241]	SNF8	Subtracted	209.299	249.187	39.888
	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	HOMER1	Divided	252.309	201.998	1.24907
108	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	HOMER3		252.296	201.995	1.24902
	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	SLC39A6	Subtracted	209.299	249.187	39.888
109	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	GAD2
	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	GNB4	Divided	266.933	333.281	1.24856
110	deltex 2. [refseq;acc:nm_020892]	DTX2		333.144	267.393	1.2459
	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	NAPG	Subtracted	209.299	249.187	39.888
111	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	DTX1	Divided	332.925	267.274	1.24563
	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	GAD1	Subtracted	209.299	249.187	39.888
112	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	POLE4		275.754	235.908	39.846
	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	PBK	Divided	332.874	267.246	1.24557
113	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	KHDRBS3
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	PPP2CA	Subtracted	194.372	234.204	39.832
114	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	B9D1		229.818	267.265	37.447
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	KHDRBS1	Divided	332.874	267.246	1.24557
115	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	HAT1	Subtracted	277.546	240.461	37.085
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	KHDRBS2	Divided	332.874	267.246	1.24557
116	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	GNB3		268.565	334.483	1.24545

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.