MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Hugo	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 182 to 231 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	Hugo	red	green	network_comparison
46	Ranked	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	FOSL1	204.642	161.068	1.27053
	Squared	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	ATG3	129597	73157.5	1.77148
	Rooted	deltex 2. [refseq;acc:nm_020892]	DTX2	27.634	43.9629	1.5909
47	Measured	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	CHD3	779.167	1390.33	1.78438
	Ranked	gbp protein isoform a. [refseq;acc:nm_017870]	TMEM132A	325.586	256.492	1.26938
	Squared	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	no value	98517.9	56927.2	1.73059
	Rooted	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	DTX1	27.7078	44.017	1.58861
48	Measured	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	CDK2AP2	779.167	1390.33	1.78438
	Ranked	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	GABARAP	65.4586	83.0461	1.26868
	Squared	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	LASS2	6300.2	10703.5	1.69891
	Rooted	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	PBK	27.7254	44.0299	1.58807
49	Measured	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	NEUROD6	779.167	1390.33	1.78438
	Ranked	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	ARRB2	133	105	1.26667
	Squared	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	STAMBPL1	28994.2	17134.8	1.69212
	Rooted	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	KHDRBS3	27.7254	44.0299	1.58807
50	Measured	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	NEUROD1	779.167	1390.33	1.78438
	Ranked	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	ARRB1	133	105	1.26667
	Squared	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	CHMP2A	28994.2	17134.8	1.69212
	Rooted	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	KHDRBS1	27.7254	44.0299	1.58807
51	Measured	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	NEUROD4	779.167	1390.33	1.78438
	Ranked	spermatogenesis associated 6. [refseq;acc:nm_019073]	SPATA6	133	105	1.26667
	Squared	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	STAMBP	28994.2	17134.8	1.69212
	Rooted	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	KHDRBS2	27.7254	44.0299	1.58807
52	Measured	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	CHD5	779.167	1390.33	1.78438
	Ranked	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	AMPD2	133	105	1.26667
	Squared	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	VPS24	28994.2	17134.8	1.69212
	Rooted	neuralized-like. [refseq;acc:nm_004210]	NEURL	27.9107	44.1656	1.58239
53	Measured	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	CDK2AP1	779.167	1390.33	1.78438
	Ranked	transcription factor jun-b. [swissprot;acc:p17275]	JUNB	201.144	158.868	1.26611
	Squared	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	CHMP4A	28994.2	17134.8	1.69212
	Rooted	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	NDUFS4	30.8986	46.4619	1.50369
54	Measured	deltex 2. [refseq;acc:nm_020892]	DTX2	1618.84	2651.88	1.63814
	Ranked	transcription factor jun-d. [swissprot;acc:p17535]	JUND	200.941	158.941	1.26425
	Squared	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	MAGED4	219048	129762	1.68808
	Rooted	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	UFC1	40.0958	58.7986	1.46645
55	Measured	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	DTX1	1629.21	2662.12	1.63399
	Ranked	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	PRKRAP1	320.927	254.434	1.26134
	Squared	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	MAGEE2	219048	129762	1.68808
	Rooted	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	KCND2	41.6734	28.9323	1.44038
56	Measured	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	PBK	1631.67	2664.55	1.63302
	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	no value	266.856	336.233	1.25998
	Squared	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]		219048	129762	1.68808
	Rooted	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	CTH	41.6851	28.9509	1.43986
57	Measured	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	KHDRBS3	1631.67	2664.55	1.63302
	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	GNG12	266.856	336.233	1.25998
	Squared	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	MAGEA11	219048	129762	1.68808
	Rooted	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	KCND3	41.6879	28.9554	1.43973
58	Measured	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	KHDRBS1	1631.67	2664.55	1.63302
	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	GNG4	266.863	336.191	1.25979
	Squared	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	MAGEA2B	219048	129762	1.68808

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.