MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1808 to 1857 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	network_comparison	green
904	EIF3A	eukaryotic translation initiation factor 3 subunit 10 (eif-3 theta) (eif3 p167) (eif3 p180) (eif3 p185) (eif3a). [swissprot;acc:q14152]	Divided	246.354	1.03849	237.223
905	no value	dna directed rna polymerase ii polypeptide j-related gene isoform 3; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_032959]		230.768	1.03841	239.632
		ero1-like. [refseq;acc:nm_014584]	Subtracted	217.168	7.961	209.207
906		dna directed rna polymerase ii polypeptide j-related gene isoform 1; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_145325]	Divided	230.764	1.03838	239.62
	RSL1D1	pbk1 protein. [sptrembl;acc:o76021]	Subtracted	243.312	7.959	235.353
907	JUP	junction plakoglobin (desmoplakin iii). [swissprot;acc:p14923]	Divided	223.906	1.03827	215.653
	MTRF1	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	Subtracted	225.976	7.959	218.017
908	no value	tax interaction protein 1. [refseq;acc:nm_014604]	Divided	223.906	1.03827	215.653
	ZNF547	sedlin. [swissprot;acc:o14582]	Subtracted	129.219	7.958	121.261
909	no value	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]
	SEPT1	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	Divided	142.077	1.03823	136.846
910	no value	uba/ubx 33.3 kda protein. [swissprot;acc:q04323]		217.168	1.03805	209.207
	TRAPPC3	bet3 homolog. [swissprot;acc:o43617]	Subtracted	129.219	7.958	121.261
911	no value	ero1-like. [refseq;acc:nm_014584]	Divided	217.168	1.03805	209.207
	MPDU1	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	Subtracted	225.955	7.94	218.015
912	MTRF1L	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]		225.939	7.926	218.013
	WDR3	wd-repeat protein 3. [swissprot;acc:q9unx4]	Divided	243.896	1.03803	234.96
913	DDX52	atp-dependent rna helicase rok1; atp-dependent rna helicase. [refseq;acc:nm_007010]	Subtracted	243.297	7.924	235.373
	TGS1	prip-interacting protein pipmt; prip-interacting protein with methyltransferase domain. [refseq;acc:nm_024831]	Divided	210.863	1.03801	218.878
914	no value	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	Subtracted	237.558	7.881	229.677
	GOPC	pdz/coiled-coil domain binding partner for the rho-family gtpase tc10; fused in glioblastoma; golgi associated pdz and coiled-coil motif containing protein; cftr-associated ligand. [refseq;acc:nm_020399]	Divided	210.863	1.03801	218.878
915	TRMU	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]		146.036	1.03798	140.692
	ZRF1	zuotin related factor-1 (m-phase phosphoprotein 11). [swissprot;acc:q99543]	Subtracted	237.558	7.881	229.677
916	no value	histone h4. [swissprot;acc:p02304]		227.765	7.863	219.902
	HAO2	hydroxyacid oxidase 2 (ec 1.1.3.15) (haox2) ((s)-2-hydroxy-acid oxidase, peroxisomal) (long chain alpha-hydroxy acid oxidase) (long- chain l-2-hydroxy acid oxidase). [swissprot;acc:q9nyq3]	Divided	232.512	1.03774	241.288
917	CDC73	parafibromin. [refseq;acc:nm_024529]		239.704	1.03772	230.991
	DNASE2B	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Subtracted	86.7483	7.8488	78.8995
918	IMMP2L	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]		217.942	7.803	210.139
	SORBS1	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Divided	212.952	1.03731	205.292
919	no value	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	Subtracted	217.942	7.803	210.139
	MDN1	midasin (midas-containing protein). [swissprot;acc:q9nu22]	Divided	237.218	1.03725	228.698
920	BRCA1	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	Subtracted	216.501	7.769	224.27
	DEAF1	deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398]	Divided	236.741	1.0372	245.547
921	RIOK1	rio kinase 1 isoform 1; ad034 protein. [refseq;acc:nm_031480]
	WDR46	wd-repeat protein bing4. [swissprot;acc:o15213]	Subtracted	243.227	7.752	235.475
922	MARK1	map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]	Divided	236.741	1.0372	245.547
	PEF1	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	Subtracted	215.665	7.723	207.942
923	HPRT1	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]		193.114	7.702	185.412
	MARK2	map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]	Divided	236.741	1.0372	245.547
924	no value	sh2 domain binding protein 1; tpr-containing, sh2-binding phosphoprotein. [refseq;acc:nm_014633]	Subtracted	238.725	7.666	231.059
	SPO11	meiotic recombination protein spo11. [swissprot;acc:q9y5k1]	Divided	236.741	1.0372	245.547
925	HEATR1	protein bap28. [swissprot;acc:q9h583]	Subtracted	244.312	7.665	236.647
	PEF1	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	Divided	215.665	1.03714	207.942
926	IMMP2L	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]		217.942	1.03713	210.139
	SORBS1	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Subtracted	212.952	7.66	205.292
927	no value	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	Divided	217.942	1.03713	210.139
	SF3A3	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	Subtracted	220.246	7.628	212.618
928	MTRF1	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	Divided	225.976	1.03651	218.017
	SF3A1	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	Subtracted	220.246	7.628	212.618
929	AATF	apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]		243.045	7.623	235.422

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.