MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1775 to 1824 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Interaction Map	red	network_comparison	green
444	u5 snrnp-associated 102 kda protein (u5-102 kda protein). [swissprot;acc:o94906]	PRPF6	Divided	Low confidence	207.002	1.03467	200.066
	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (ec 2.7.1.115) (branched-chain alpha-ketoacid dehydrogenase kinase) (bckdhkin) (bckd-kinase). [swissprot;acc:o14874]	BCKDK	Subtracted		202.714	6.889	195.825
445	dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]	DPP6			202.75	6.871	195.879
	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	NAV3	Divided	High confidence	223.801	1.0783	207.549
	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	GNL3	Subtracted		250.858	16.295	234.563
	serologically defined colon cancer antigen 16. [refseq;acc:nm_006649]	UTP14A	Divided	Low confidence	206.703	1.03464	199.782
446	dipeptidylpeptidase 10; dipeptidyl peptidase iv-related protein 3. [refseq;acc:nm_020868]	DPP10	Subtracted		202.75	6.87	195.88
	f16601_1, partial cds (fragment). [sptrembl;acc:o75274]	JMJD2B	Divided		206.703	1.03464	199.782
	growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]	GRB2		High confidence	224.049	1.07827	207.785
			Subtracted			16.264
447	gene amplified in squamous cell carcinoma 1. [refseq;acc:nm_015061]	JMJD2C	Divided	Low confidence	206.703	1.03464	199.782
	seprase (ec 3.4.21.-) (fibroblast activation protein alpha) (integral membrane serine protease) (170-kda melanoma membrane-bound gelatinase). [swissprot;acc:q12884]	FAP	Subtracted		202.752	6.87	195.882
	serine/threonine-protein kinase nek2 (ec 2.7.1.37) (nima-related protein kinase 2) (nima-like protein kinase 1) (hspk 21). [swissprot;acc:p51955]	NEK2	Divided	High confidence	224.049	1.07827	207.785
			Subtracted			16.264
448	dj18d14.4 (cytochrome p450, subfamily iva, polypeptide 11). [sptrembl;acc:q9ntl5]	CYP4A22	Divided	Low confidence	203.074	1.03463	196.277
	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	ANKS1B	Subtracted	High confidence	223.802	16.252	207.55
	microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	MACF1	Divided		228.468	1.07822	246.338
	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 2). [swissprot;acc:q15119]	PDK2	Subtracted	Low confidence	202.782	6.855	195.927
449	bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]	DST	Divided	High confidence	228.463	1.07821	246.33
	cytochrome p450 4a11 precursor (ec 1.14.15.3) (cypiva11) (fatty acid omega-hydroxylase) (p-450 hk omega) (lauric acid omega-hydroxylase) (cyp4aii) (p450-hl-omega). [swissprot;acc:q02928]	CYP4A11		Low confidence	203.077	1.03461	196.283
	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	NAV1	Subtracted	High confidence	223.801	16.252	207.549
	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 1). [swissprot;acc:q15118]	PDK1		Low confidence	202.782	6.854	195.928
450	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	no value	Divided		207.786	1.03459	200.839
	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	CYP4X1	Subtracted		203.045	6.841	196.204
	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	NAV3		High confidence	223.801	16.252	207.549
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	SRP9	Divided		235.94	1.07815	218.837
451	cytochrome p450 4b1 (ec 1.14.14.1) (cypivb1) (p450-hp). [swissprot;acc:p13584]	CYP4B1	Subtracted	Low confidence	203.045	6.841	196.204
	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	NAV2		High confidence	223.79	16.251	207.539
	polymerase (rna) iii (dna directed) (62kd). [refseq;acc:nm_006468]	POLR3C	Divided		239.092	1.07785	257.705
	similar to lim domain only 7 (fragment). [sptrembl;acc:q8n6m2]	LIMCH1		Low confidence	210.594	1.03455	203.561
452	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	no value		High confidence	224.161	1.07784	207.972
	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	PRPF19		Low confidence	202.01	1.03454	195.266
	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	POLI	Subtracted	High confidence	221.522	16.236	205.286
	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	SNRPD2		Low confidence	201.134	6.832	194.302
453	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	HS3ST6			207.812	6.818	200.994
	ny-ren-24 antigen (fragment). [sptrembl;acc:q9y5a4]	C19orf29	Divided		210.727	1.03453	203.693
	paxillin. [swissprot;acc:p49023]	PXN	Subtracted	High confidence	221.522	16.236	205.286
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	SNRPA1	Divided		224.161	1.07784	207.972
454	40s ribosomal protein s26. [swissprot;acc:p02383]	no value			210.224	1.07779	226.578
	grb2-related adaptor protein. [swissprot;acc:q13588]	GRAP	Subtracted		223.457	16.235	207.222
	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	HS3ST3A1		Low confidence	207.812	6.818	200.994
	voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1]	CACNG4	Divided		210.252	1.0345	203.24
455	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	no value	Subtracted	High confidence	224.161	16.189	207.972
	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	HS3ST3B1		Low confidence	207.812	6.818	200.994
	mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	TIMM22	Divided	High confidence	210.225	1.07779	226.578
	voltage-dependent calcium channel gamma-2 subunit (neuronal voltage- gated calcium channel gamma-2 subunit). [swissprot;acc:q9y698]	CACNG2		Low confidence	210.251	1.03449	203.241
456	atp synthase mitochondrial f1 complex assembly factor 2. [refseq;acc:nm_145691]	ATPAF2		High confidence	210.225	1.07779	226.578
	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	HS3ST2	Subtracted	Low confidence	207.812	6.818	200.994
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	SNRPA1		High confidence	224.161	16.189	207.972
	voltage-dependent calcium channel gamma-8 subunit (neuronal voltage- gated calcium channel gamma-8 subunit). [swissprot;acc:q8wxs5]	CACNG8	Divided	Low confidence	210.251	1.03449	203.241

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.