MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1775 to 1824 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
888	no value	nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594]	Divided	212.027	204.05	1.03909
	PRKAA2	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	Subtracted	212.002	203.954	8.048
889	no value	alpha-nac protein. [sptrembl;acc:q9h009]	Divided	212.028	204.053	1.03908
	PRKAA1	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	Subtracted	212.002	203.954	8.048
890	PRKAB2	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]
	STX7	syntaxin 7. [swissprot;acc:o15400]	Divided	217.181	209.012	1.03908
891	DIRAS1	small gtp-binding tumor suppressor 1. [refseq;acc:nm_145173]		212.028	204.055	1.03907
	PRKAG3	5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	Subtracted	212.002	203.954	8.048
892	DIRAS2	di-ras2. [refseq;acc:nm_017594]	Divided	212.028	204.055	1.03907
	PRKAB1	5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	Subtracted	212.002	203.954	8.048
893	MYC	myc proto-oncogene protein (c-myc). [swissprot;acc:p01106]	Divided	227.585	219.037	1.03903
	PRKAG2	5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	Subtracted	212.002	203.954	8.048
894	FARSA	phenylalanyl-trna synthetase alpha chain (ec 6.1.1.20) (phenylalanine- -trna ligase alpha chain) (phers) (cml33). [swissprot;acc:q9y285]	Divided	217.491	209.323	1.03902
	MRPL27	mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	Subtracted	231.163	239.205	8.042
895	ACADVL	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]		164	155.961	8.039
	FARS2	phenylalanine-trna synthetase. [refseq;acc:nm_006567]	Divided	217.491	209.323	1.03902
896	POLR2J	dna-directed rna polymerase ii 13.3 kda polypeptide (ec 2.7.7.6) (rpb11). [swissprot;acc:p52435]		230.811	239.785	1.03888
	WDR36	t-cell activation wd repeat protein. [refseq;acc:nm_139281]	Subtracted	243.34	235.322	8.018
897	PDPK1	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	Divided	272.878	283.472	1.03882
	TGS1	prip-interacting protein pipmt; prip-interacting protein with methyltransferase domain. [refseq;acc:nm_024831]	Subtracted	210.863	218.878	8.015
898	no value	60s acidic ribosomal protein p1. [swissprot;acc:p05386]	Divided	229.171	238.048	1.03874
	GOPC	pdz/coiled-coil domain binding partner for the rho-family gtpase tc10; fused in glioblastoma; golgi associated pdz and coiled-coil motif containing protein; cftr-associated ligand. [refseq;acc:nm_020399]	Subtracted	210.863	218.878	8.015
899	no value	nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594]		212.027	204.05	7.977
	TXNDC2	thioredoxin domain-containing 2; sperm-specific thioredoxin; thioredoxin domain-containing 2 (spermatozoa). [refseq;acc:nm_032243]	Divided	229.171	238.048	1.03874
900	no value	alpha-nac protein. [sptrembl;acc:q9h009]	Subtracted	212.028	204.053	7.975
	TXN	thioredoxin (atl-derived factor) (adf) (surface associated sulphydryl protein) (sasp). [swissprot;acc:p10599]	Divided	229.171	238.048	1.03874
901	DIRAS1	small gtp-binding tumor suppressor 1. [refseq;acc:nm_145173]	Subtracted	212.028	204.055	7.973
	SSRP1	structure-specific recognition protein 1 (ssrp1) (recombination signal sequence recognition protein) (t160) (chromatin-specific transcription elongation factor 80 kda subunit) (fact 80 kda subunit). [swissprot;acc:q08945]	Divided	237.62	228.762	1.03872
902	DIRAS2	di-ras2. [refseq;acc:nm_017594]	Subtracted	212.028	204.055	7.973
	SUPT16H	chromatin-specific transcription elongation factor large subunit. [refseq;acc:nm_007192]	Divided	237.62	228.762	1.03872
903	no value	uba/ubx 33.3 kda protein. [swissprot;acc:q04323]	Subtracted	217.168	209.207	7.961
	EIF3G	eukaryotic translation initiation factor 3 subunit 4 (eif-3 delta) (eif3 p44) (eif-3 rna-binding subunit) (eif3 p42) (eif3g). [swissprot;acc:o75821]	Divided	246.354	237.223	1.03849
904	CIRH1A	cirhin; testis expressed gene 292; cirrhosis, autosomal recessive 1a. [refseq;acc:nm_032830]	Subtracted	243.312	235.351	7.961
	EIF3A	eukaryotic translation initiation factor 3 subunit 10 (eif-3 theta) (eif3 p167) (eif3 p180) (eif3 p185) (eif3a). [swissprot;acc:q14152]	Divided	246.354	237.223	1.03849
905	no value	dna directed rna polymerase ii polypeptide j-related gene isoform 3; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_032959]		230.768	239.632	1.03841
		ero1-like. [refseq;acc:nm_014584]	Subtracted	217.168	209.207	7.961
906		dna directed rna polymerase ii polypeptide j-related gene isoform 1; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_145325]	Divided	230.764	239.62	1.03838
	RSL1D1	pbk1 protein. [sptrembl;acc:o76021]	Subtracted	243.312	235.353	7.959
907	JUP	junction plakoglobin (desmoplakin iii). [swissprot;acc:p14923]	Divided	223.906	215.653	1.03827
	MTRF1	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	Subtracted	225.976	218.017	7.959
908	no value	tax interaction protein 1. [refseq;acc:nm_014604]	Divided	223.906	215.653	1.03827
	ZNF547	sedlin. [swissprot;acc:o14582]	Subtracted	129.219	121.261	7.958
909	no value	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]
	SEPT1	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	Divided	142.077	136.846	1.03823
910	no value	uba/ubx 33.3 kda protein. [swissprot;acc:q04323]		217.168	209.207	1.03805
	TRAPPC3	bet3 homolog. [swissprot;acc:o43617]	Subtracted	129.219	121.261	7.958
911	no value	ero1-like. [refseq;acc:nm_014584]	Divided	217.168	209.207	1.03805
	MPDU1	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	Subtracted	225.955	218.015	7.94
912	MTRF1L	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]		225.939	218.013	7.926
	WDR3	wd-repeat protein 3. [swissprot;acc:q9unx4]	Divided	243.896	234.96	1.03803

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.