MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1758 to 1807 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
879	PRKAB1	5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	High confidence	212.002	203.954	1.03946
880	PRKAG2	5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]
	RRM2	ribonucleoside-diphosphate reductase m2 chain (ec 1.17.4.1) (ribonucleotide reductase small chain). [swissprot;acc:p31350]	Low confidence	201.49	196.469	1.02556
881	MAX	max protein. [swissprot;acc:p25912]		204.973	199.865
	MYCL1	l-myc-1 proto-oncogene protein. [swissprot;acc:p12524]	High confidence	227.604	219.001	1.03928
882	MYCN	n-myc proto-oncogene protein. [swissprot;acc:p04198]		227.601	219.008	1.03924
	STX1A	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	Low confidence	210.979	205.723	1.02555
883	no value	nadh-ubiquinone oxidoreductase mlrq subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-mlrq) (ci-mlrq). [swissprot;acc:o00483]		202.572	197.533	1.02551
	GABPA	ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546]	High confidence	227.596	219.017	1.03917
884	no value	ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545]
	NDUFA4L2	nadh:ubiquinone oxidoreductase mlrq subunit homolog (nuoms). [swissprot;acc:q9nrx3]	Low confidence	202.572	197.533	1.02551
885	CDC5L	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]
	NDUFS8	nadh-ubiquinone oxidoreductase 23 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-23kd) (ci-23kd) (tyky subunit). [swissprot;acc:o00217]	High confidence	227.596	219.017	1.03917
886	ELOVL1	elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]			219.018
	LIG4	dna ligase iv (ec 6.5.1.1) (polydeoxyribonucleotide synthase [atp]). [swissprot;acc:p49917]	Low confidence	202.568	197.535	1.02548
887	EIF4E	eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730]		202.277	197.255	1.02546
	TBL3	transducin beta-like 3; wd-repeat protein sazd. [refseq;acc:nm_006453]	High confidence	244.155	234.96	1.03913
888	no value	nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594]		212.027	204.05	1.03909
	EIF4EBP2	eukaryotic translation initiation factor 4e binding protein 2; eukaryotic translation initiation factor-4e binding protein-1. [refseq;acc:nm_004096]	Low confidence	202.277	197.255	1.02546
889	no value	alpha-nac protein. [sptrembl;acc:q9h009]	High confidence	212.028	204.053	1.03908
	ANKHD1-EIF4EBP3	eukaryotic translation initiation factor 4e binding protein 3; eukaryotic initiation factor 4e-binding protein 3. [refseq;acc:nm_003732]	Low confidence	202.277	197.255	1.02546
890	BAIAP3	bai1-associated protein 3; bai-associated protein 3. [refseq;acc:nm_003933]
	STX7	syntaxin 7. [swissprot;acc:o15400]	High confidence	217.181	209.012	1.03908
891	DIRAS1	small gtp-binding tumor suppressor 1. [refseq;acc:nm_145173]		212.028	204.055	1.03907
	ETF1	eukaryotic peptide chain release factor subunit 1 (erf1) (eukaryotic release factor 1) (tb3-1) (c11 protein). [swissprot;acc:p46055]	Low confidence	203.493	198.443	1.02545
892	DIRAS2	di-ras2. [refseq;acc:nm_017594]	High confidence	212.028	204.055	1.03907
	TSC1	hamartin (tuberous sclerosis 1 protein). [swissprot;acc:q92574]	Low confidence	202.488	197.465	1.02544
893	MYC	myc proto-oncogene protein (c-myc). [swissprot;acc:p01106]	High confidence	227.585	219.037	1.03903
	RRM2B	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	Low confidence	201.434	196.441	1.02542
894	no value	rab gdp dissociation inhibitor alpha (rab gdi alpha) (gdi-1) (xap-4) (oligophrenin 2). [swissprot;acc:p31150]		204.25	199.19	1.0254
	FARSA	phenylalanyl-trna synthetase alpha chain (ec 6.1.1.20) (phenylalanine- -trna ligase alpha chain) (phers) (cml33). [swissprot;acc:q9y285]	High confidence	217.491	209.323	1.03902
895	FARS2	phenylalanine-trna synthetase. [refseq;acc:nm_006567]
	GLRX2	glutaredoxin 2; cgi-133 protein. [refseq;acc:nm_016066]	Low confidence	203.861	198.812	1.0254
896	COL6A2	collagen alpha 2(vi) chain precursor. [swissprot;acc:p12110]		205.315	200.235	1.02537
	POLR2J	dna-directed rna polymerase ii 13.3 kda polypeptide (ec 2.7.7.6) (rpb11). [swissprot;acc:p52435]	High confidence	230.811	239.785	1.03888
897	PDPK1	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]		272.878	283.472	1.03882
	PES1	pescadillo homolog 1. [swissprot;acc:o00541]	Low confidence	202.55	197.54	1.02536
898	no value	60s acidic ribosomal protein p1. [swissprot;acc:p05386]	High confidence	229.171	238.048	1.03874
	WAS	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	Low confidence	198.379	193.474	1.02535
899	KYNU	kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719]		190.965	186.246	1.02534
	TXNDC2	thioredoxin domain-containing 2; sperm-specific thioredoxin; thioredoxin domain-containing 2 (spermatozoa). [refseq;acc:nm_032243]	High confidence	229.171	238.048	1.03874
900	RHD	blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	Low confidence	201.015	196.054	1.0253
	TXN	thioredoxin (atl-derived factor) (adf) (surface associated sulphydryl protein) (sasp). [swissprot;acc:p10599]	High confidence	229.171	238.048	1.03874
901	no value	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	Low confidence	201.015	196.054	1.0253
	SSRP1	structure-specific recognition protein 1 (ssrp1) (recombination signal sequence recognition protein) (t160) (chromatin-specific transcription elongation factor 80 kda subunit) (fact 80 kda subunit). [swissprot;acc:q08945]	High confidence	237.62	228.762	1.03872
902	PAPD5	topoisomerase-related function protein 4-2. [refseq;acc:nm_022447]	Low confidence	203.074	198.063	1.0253
	SUPT16H	chromatin-specific transcription elongation factor large subunit. [refseq;acc:nm_007192]	High confidence	237.62	228.762	1.03872
903	no value	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	Low confidence	201.015	196.054	1.0253
	EIF3G	eukaryotic translation initiation factor 3 subunit 4 (eif-3 delta) (eif3 p44) (eif-3 rna-binding subunit) (eif3 p42) (eif3g). [swissprot;acc:o75821]	High confidence	246.354	237.223	1.03849
904	EIF3A	eukaryotic translation initiation factor 3 subunit 10 (eif-3 theta) (eif3 p167) (eif3 p180) (eif3 p185) (eif3a). [swissprot;acc:q14152]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.