MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1732 to 1781 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
866	SRP68	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	Divided	221.306	212.806	1.03994
867	no value	40s ribosomal protein s3a. [swissprot;acc:p49241]		225.689	234.674	1.03981
	ZNF18	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	Subtracted	269.956	278.223	8.267
868	MVD	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	Divided	233.298	242.571	1.03975
	ZNF215	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	Subtracted	269.956	278.223	8.267
869	EXOC4	exocyst complex component sec8. [swissprot;acc:q96a65]	Divided	217.762	209.449	1.03969
	ZNF24	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	Subtracted	269.955	278.221	8.266
870	no value	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	Divided	211.908	203.832	1.03962
	ZSCAN12	zinc finger protein 305. [swissprot;acc:o43309]	Subtracted	269.954	278.219	8.265
871	CPSF2	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Divided	110.2	114.552	1.03949
	ZNF232	zinc finger protein 232. [swissprot;acc:q9uny5]	Subtracted	269.954	278.218	8.264
872	HNRPK	heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244]	Divided	224.413	233.272	1.03948
	ZNF394	zinc finger protein 99. [refseq;acc:nm_032164]	Subtracted	269.954	278.218	8.264
873	PRPF4	u4/u6 small nuclear ribonucleoprotein prp4 (u4/u6 snrnp 60 kda protein) (wd splicing factor prp4) (hprp4). [swissprot;acc:o43172]	Divided	224.413	233.272	1.03948
	ZNF213	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	Subtracted	269.954	278.217	8.263
874	PRKAG1	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	Divided	212.002	203.954	1.03946
	ZNF274	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	Subtracted	269.953	278.215	8.262
875	JUP	junction plakoglobin (desmoplakin iii). [swissprot;acc:p14923]		223.906	215.653	8.253
	PRKAA2	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	Divided	212.002	203.954	1.03946
876	no value	tax interaction protein 1. [refseq;acc:nm_014604]	Subtracted	223.906	215.653	8.253
	PRKAA1	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	Divided	212.002	203.954	1.03946
877	PRKAB2	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]
	ZNF444	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	Subtracted	269.896	278.093	8.197
878	PRKAG3	5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	Divided	212.002	203.954	1.03946
	STX7	syntaxin 7. [swissprot;acc:o15400]	Subtracted	217.181	209.012	8.169
879	FARSA	phenylalanyl-trna synthetase alpha chain (ec 6.1.1.20) (phenylalanine- -trna ligase alpha chain) (phers) (cml33). [swissprot;acc:q9y285]		217.491	209.323	8.168
	PRKAB1	5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	Divided	212.002	203.954	1.03946
880	FARS2	phenylalanine-trna synthetase. [refseq;acc:nm_006567]	Subtracted	217.491	209.323	8.168
	PRKAG2	5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	Divided	212.002	203.954	1.03946
881	BTF3	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	Subtracted	211.961	203.814	8.147
	MYCL1	l-myc-1 proto-oncogene protein. [swissprot;acc:p12524]	Divided	227.604	219.001	1.03928
882	MYCN	n-myc proto-oncogene protein. [swissprot;acc:p04198]		227.601	219.008	1.03924
	TOMM20	mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	Subtracted	198.781	190.66	8.121
883	GABPA	ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546]	Divided	227.596	219.017	1.03917
	PEX19	peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]	Subtracted	198.781	190.66	8.121
884	no value	ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545]	Divided	227.596	219.017	1.03917
		sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	Subtracted	232.473	224.372	8.101
885		casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]
	NDUFS8	nadh-ubiquinone oxidoreductase 23 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-23kd) (ci-23kd) (tyky subunit). [swissprot;acc:o00217]	Divided	227.596	219.017	1.03917
886	no value	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	Subtracted	211.908	203.832	8.076
	ELOVL1	elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]	Divided	227.596	219.018	1.03917
887	PRKAG1	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	Subtracted	212.002	203.954	8.048
	TBL3	transducin beta-like 3; wd-repeat protein sazd. [refseq;acc:nm_006453]	Divided	244.155	234.96	1.03913
888	no value	nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594]		212.027	204.05	1.03909
	PRKAA2	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	Subtracted	212.002	203.954	8.048
889	no value	alpha-nac protein. [sptrembl;acc:q9h009]	Divided	212.028	204.053	1.03908
	PRKAA1	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	Subtracted	212.002	203.954	8.048
890	PRKAB2	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]
	STX7	syntaxin 7. [swissprot;acc:o15400]	Divided	217.181	209.012	1.03908
891	DIRAS1	small gtp-binding tumor suppressor 1. [refseq;acc:nm_145173]		212.028	204.055	1.03907

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.