MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Network Comparison Type	Gene	Hugo	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1730 to 1779 of 2061 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
red  : 0
green  : 0
network_comparison  : 0

Rank	Hugo	description	Value Type
3188	WISP2	connective tissue growth factor-like protein precursor (ctgf-l) (wnt1 inducible signaling pathway protein 2) (wisp-2) (connective tissue growth factor-related protein 58). [swissprot;acc:o76076]	Ranked
			Squared
			Rooted
3189	RNF4	ring finger protein 4. [swissprot;acc:p78317]	Measured
			Ranked
			Squared
			Rooted
3190	MTMR1	myotubularin-related protein 1 (ec 3.1.3.-). [swissprot;acc:q13613]	Measured
			Ranked
			Squared
			Rooted
3191	APPBP2	amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	Measured
			Ranked
			Squared
			Rooted
3192	USP13	ubiquitin carboxyl-terminal hydrolase 13 (ec 3.1.2.15) (ubiquitin thiolesterase 13) (ubiquitin-specific processing protease 13) (deubiquitinating enzyme 13) (isopeptidase t-3) (isot-3). [swissprot;acc:q92995]	Measured
			Ranked
			Squared
			Rooted
3193	GDI2	rab gdp dissociation inhibitor beta (rab gdi beta) (gdi-2). [swissprot;acc:p50395]	Measured
			Ranked
			Squared
			Rooted
3194	MSH4	muts protein homolog 4. [swissprot;acc:o15457]	Measured
			Ranked
			Squared
			Rooted
3195	ITGB3	integrin beta-3 precursor (platelet membrane glycoprotein iiia) (gpiiia) (cd61 antigen). [swissprot;acc:p05106]	Measured
			Ranked
			Squared
			Rooted
3196	HERPUD1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (methyl methanesulfonate (mmf)-inducible fragment protein 1). [swissprot;acc:q15011]	Measured
			Ranked
			Squared
			Rooted
3197	CLPTM1L	cisplatin resistance related protein crr9p. [refseq;acc:nm_030782]	Measured
			Ranked
			Squared
			Rooted
3198	DCUN1D1	rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640]	Measured
			Ranked
			Squared
			Rooted
3199	C6	complement component c6 precursor. [swissprot;acc:p13671]	Measured
			Ranked
			Squared
			Rooted
3200	ZFYVE16	endosome-associated fyve-domain protein. [refseq;acc:nm_014733]	Measured
			Ranked
			Squared

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.