MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1708 to 1757 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
854	QPRT	nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274]	Low confidence	201.613	196.545	1.02579
855	CLEC3B	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	High confidence	178.514	171.42	1.04138
	HAGH	hydroxyacylglutathione hydrolase (ec 3.1.2.6) (glyoxalase ii) (glx ii). [swissprot;acc:q16775]	Low confidence	200.822	195.773	1.02579
856	SLC16A3	monocarboxylate transporter 4 (mct 4) (mct 3). [swissprot;acc:o15427]		183.826	179.209	1.02576
	XPR1	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	High confidence	215.028	206.623	1.04068
857	PNO1	putatative 28 kda protein. [refseq;acc:nm_020143]		227.241	236.467	1.0406
	PSMD1	26s proteasome non-atpase regulatory subunit 1 (26s proteasome regulatory subunit s1) (26s proteasome subunit p112). [swissprot;acc:q99460]	Low confidence	204.36	199.229	1.02575
858	SLC16A8	monocarboxylate transporter 3 (mct 3). [swissprot;acc:o95907]		183.673	179.063
	STX12	syntaxin 12. [refseq;acc:nm_177424]	High confidence	217.446	208.997	1.04043
859	no value	60s ribosomal protein l39. [swissprot;acc:p02404]		234.025	224.958	1.04031
	SLC16A1	monocarboxylate transporter 1 (mct 1). [swissprot;acc:p53985]	Low confidence	183.611	179.004	1.02574
860	no value	60s ribosomal protein l18a. [swissprot;acc:q02543]	High confidence	234.025	224.958	1.04031
	SLC16A5	monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375]	Low confidence	183.58	178.975	1.02573
861	RPS19	40s ribosomal protein s19. [swissprot;acc:p39019]	High confidence	234.025	224.958	1.04031
	SLC16A4	monocarboxylate transporter 5 (mct 5) (mct 4). [swissprot;acc:o15374]	Low confidence	200.605	195.573	1.02573
862	RPL31	60s ribosomal protein l31. [swissprot;acc:p12947]	High confidence	234.025	224.958	1.04031
	SLC16A7	monocarboxylate transporter 2 (mct 2). [swissprot;acc:o60669]	Low confidence	183.625	179.018	1.02573
863	CSNK2A1P	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	High confidence	240.194	230.957	1.03999
	NOL1	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	Low confidence	202.981	197.889	1.02573
864	CSNK2A2	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	High confidence	240.194	230.957	1.03999
	SLC16A6	monocarboxylate transporter 7 (mct 7) (mct 6). [swissprot;acc:o15403]	Low confidence	200.605	195.573	1.02573
865	BTF3	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	High confidence	211.961	203.814	1.03997
	G3BP2	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]	Low confidence	210.933	216.358	1.02572
866	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]		207.56	202.355
	SRP68	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	High confidence	221.306	212.806	1.03994
867	no value	40s ribosomal protein s3a. [swissprot;acc:p49241]		225.689	234.674	1.03981
	EIF3D	eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371]	Low confidence	205.551	200.398	1.02571
868	COX4I2	cytochrome c oxidase subunit iv isoform 2, mitochondrial precursor (ec 1.9.3.1) (cox iv-2). [swissprot;acc:q96kj9]		204.037	198.928	1.02568
	MVD	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	High confidence	233.298	242.571	1.03975
869	EXOC4	exocyst complex component sec8. [swissprot;acc:q96a65]		217.762	209.449	1.03969
	ZNHIT4	pap-1 binding protein. [refseq;acc:nm_031288]	Low confidence	213.16	218.629	1.02566
870	no value	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	High confidence	211.908	203.832	1.03962
	HNRPM	heterogeneous nuclear ribonucleoprotein m (hnrnp m). [swissprot;acc:p52272]	Low confidence	208.623	213.975	1.02565
871	CPSF2	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	High confidence	110.2	114.552	1.03949
	HPRT1	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	Low confidence	191.561	186.777	1.02561
872	HNRPK	heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244]	High confidence	224.413	233.272	1.03948
	NDUFA5	nadh-ubiquinone oxidoreductase 13 kda-b subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-13kd-b) (ci-13kd-b) (complex i subunit b13). [swissprot;acc:q16718]	Low confidence	203.141	198.068	1.02561
873	PRPF4	u4/u6 small nuclear ribonucleoprotein prp4 (u4/u6 snrnp 60 kda protein) (wd splicing factor prp4) (hprp4). [swissprot;acc:o43172]	High confidence	224.413	233.272	1.03948
	PTPMT1	nadh-ubiquinone oxidoreductase 30 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-30kd) (ci-30kd). [swissprot;acc:o75489]	Low confidence	203.141	198.068	1.02561
874	EIF3E	eukaryotic translation initiation factor 3 subunit 6 (eif-3 p48) (eif3e) (mammary tumor-associated protein int-6) (viral integration site protein int-6). [swissprot;acc:q64252]
	PRKAG1	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	High confidence	212.002	203.954	1.03946
875	BDP1	transcription factor-like nuclear regulator; putative transcription regulation nuclear protein; putative transcription factor-like nuclear regulator; tata box binding protein (tbp)-associated factor, rna polymerase iii, gtf3b subunit 1; b''90 component. [refseq;acc:nm_018429]	Low confidence	203.139	198.068	1.0256
	PRKAA2	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	High confidence	212.002	203.954	1.03946
876	BBOX1	gamma-butyrobetaine,2-oxoglutarate dioxygenase (ec 1.14.11.1) (gamma-butyrobetaine hydroxylase) (gamma-bbh). [swissprot;acc:o75936]	Low confidence	203.744	198.658	1.0256
	PRKAA1	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	High confidence	212.002	203.954	1.03946
877	DHX35	probable atp-dependent helicase ddx35 (deah-box protein 35). [swissprot;acc:q9h5z1]	Low confidence	205.571	200.44	1.0256
	PRKAB2	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]	High confidence	212.002	203.954	1.03946
878	ATP11A	potential phospholipid-transporting atpase ih (ec 3.6.3.1) (atpase class i type 11a) (atpase is). [swissprot;acc:p98196]	Low confidence	203.744	198.658	1.0256
	PRKAG3	5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	High confidence	212.002	203.954	1.03946
879	no value	3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	Low confidence	203.354	198.284	1.02557

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.