MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Value Type	Hugo	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1708 to 1757 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Network Comparison Type	Hugo	Interaction Map	red	green	network_comparison
427	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	Subtracted	TBX6	High confidence	212.547	229.411	16.864
428	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	Divided	DDX54		253.852	234.808	1.0811
	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		ARRB2	Low confidence	194.137	187.552	1.03511
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	Subtracted	PPP2R5A		203.463	196.495	6.968
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]		LSM5	High confidence	227.748	210.888	16.86
429	dipeptidyl aminopeptidase-like protein 6 (dipeptidylpeptidase vi) (dipeptidylpeptidase 6) (dipeptidyl peptidase iv like protein) (dipeptidyl aminopeptidase-related protein) (dppx). [swissprot;acc:p42658]	Divided	DPP6	Low confidence	202.75	195.879	1.03508
	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]		POLR3G	High confidence	239.709	259.038	1.08064
	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	Subtracted	EBNA1BP2		251.344	234.514	16.83
	tetraspan net-5. [swissprot;acc:o75954]		TSPAN9	Low confidence	197.897	204.852	6.955
430	cd82 antigen (inducible membrane protein r2) (c33 antigen) (ia4) (metastasis suppressor kangai 1) (suppressor of tumorigenicity-6). [swissprot;acc:p27701]		CD82		197.9	204.85	6.95
	dipeptidylpeptidase 10; dipeptidyl peptidase iv-related protein 3. [refseq;acc:nm_020868]	Divided	DPP10		202.75	195.88	1.03507
	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]	Subtracted	PPAN-P2RY11	High confidence	250.938	234.134	16.804
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	Divided	LSM5		227.748	210.888	1.07995
431	bag-family molecular chaperone regulator-3 (bcl-2 binding athanogene- 3) (bag-3) (bcl-2-binding protein bis) (docking protein cair-1). [swissprot;acc:o95817]	Subtracted	BAG3		233.529	216.737	16.792
	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]		no value	Low confidence	207.786	200.839	6.947
	seprase (ec 3.4.21.-) (fibroblast activation protein alpha) (integral membrane serine protease) (170-kda melanoma membrane-bound gelatinase). [swissprot;acc:q12884]	Divided	FAP		202.752	195.882	1.03507
	trub pseudouridine (psi) synthase homolog 1. [refseq;acc:nm_139169]		TRUB1	High confidence	236.245	255.113	1.07987
432	endonuclease g, mitochondrial precursor (ec 3.1.30.-) (endo g). [swissprot;acc:q14249]		ENDOG		212.547	229.411	1.07934
	mct-1 protein. [refseq;acc:nm_014060]	Subtracted	MCTS1		226.313	243.03	16.717
	nicotinamide nucleotide adenylyltransferase 3; pyridine nucleotide adenylyltransferase 3. [refseq;acc:nm_178177]	Divided	NMNAT3	Low confidence	206.507	199.515	1.03504
	proactivator polypeptide precursor [contains: saposin a (protein a); saposin b (sphingolipid activator protein 1) (sap-1) (cerebroside sulfate activator) (csact) (dispersin) (sulfatide/gm1 activator); saposin c (co-beta-glucosidase) (a1 activator) (glucosylceramidase activator) (sphingolipid activator protein 2) (sap-2); saposin d (protein c) (component c)]. [swissprot;acc:p07602]	Subtracted	no value		209.188	202.243	6.945
433	mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]		MRPL22	High confidence	226.313	243.03	16.717
	programmed cell death protein 8, mitochondrial precursor (ec 1.-.-.-) (apoptosis-inducing factor). [swissprot;acc:o95831]	Divided	AIFM1		212.547	229.411	1.07934
	u5 snrnp-associated 102 kda protein (u5-102 kda protein). [swissprot;acc:o94906]	Subtracted	PRPF6	Low confidence	207.002	200.066	6.936
	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Divided	CACNG5		210.292	203.181	1.035
434	ad24 protein. [refseq;acc:nm_022451]	Subtracted	NOC3L	High confidence	251.334	234.672	16.662
	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	Divided	EGFL7	Low confidence	214.527	222.034	1.03499
	rna polymerase ii elongation factor ell (eleven-nineteen lysine-rich leukemia protein). [swissprot;acc:p55199]	Subtracted	ELL		198.572	205.504	6.932
	t-box transcription factor tbx6 (t-box protein 6). [swissprot;acc:o95947]	Divided	TBX6	High confidence	212.547	229.411	1.07934
435	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]		POLI		221.522	205.286	1.07909
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	Subtracted	PPP2R5E	Low confidence	203.448	196.524	6.924
	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]		WDR12	High confidence	251.299	234.729	16.57
	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 2). [swissprot;acc:q15119]	Divided	PDK2	Low confidence	202.782	195.927	1.03499
436	paxillin. [swissprot;acc:p49023]		PXN	High confidence	221.522	205.286	1.07909
	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	Subtracted	SF3A2	Low confidence	201.711	194.787	6.924
	triosephosphate isomerase (ec 5.3.1.1) (tim). [swissprot;acc:p00938]		TPI1	High confidence	231.496	248.048	16.552
	[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precursor (ec 2.7.1.99) (pyruvate dehydrogenase kinase isoform 1). [swissprot;acc:q15118]	Divided	PDK1	Low confidence	202.782	195.928	1.03498
437	adapter-related protein complex 2 beta 1 subunit (beta-adaptin) (plasma membrane adaptor ha2/ap2 adaptin beta subunit) (clathrin assembly protein complex 2 beta large chain) (ap105b). [swissprot;acc:p21851]		AP2B1		207.064	200.076	1.03493
	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]		TRIP10	High confidence	209.921	226.459	1.07878
		Subtracted					16.538
	krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]		KLF5	Low confidence	201.711	194.787	6.924
438	block of proliferation 1. [swissprot;acc:q14137]		BOP1	High confidence	250.794	234.433	16.361
	n-terminal acetyltransferase complex ard1 subunit homolog (ec 2.3.1.-). [swissprot;acc:p41227]	Divided	ARD1A		233.723	216.674	1.07869
	rna polymerase ii elongation factor ell (eleven-nineteen lysine-rich leukemia protein). [swissprot;acc:p55199]		ELL	Low confidence	198.572	205.504	1.03491
	serologically defined colon cancer antigen 16. [refseq;acc:nm_006649]	Subtracted	UTP14A		206.703	199.782	6.921
439	40s ribosomal protein s9. [swissprot;acc:p46781]	Divided	RPS9	High confidence	238.986	257.784	1.07866
	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]		ARRB1	Low confidence	194.237	187.689	1.03489
	f16601_1, partial cds (fragment). [sptrembl;acc:o75274]	Subtracted	JMJD2B		206.703	199.782	6.921
	pescadillo homolog 1. [swissprot;acc:o00541]		PES1	High confidence	251.297	234.941	16.356
440	40s ribosomal protein s26. [swissprot;acc:p02383]		no value		210.224	226.578	16.354

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.