MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1701 to 1750 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
851	KIAA1012	trs85 homolog. [swissprot;acc:q9y2l5]	Divided	107.842	112.329	1.04161
	MYCN	n-myc proto-oncogene protein. [swissprot;acc:p04198]	Subtracted	227.601	219.008	8.593
852	GABPA	ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546]		227.596	219.017	8.579
	HPRT1	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	Divided	193.114	185.412	1.04154
853	no value	ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545]	Subtracted	227.596	219.017	8.579
	WDR33	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Divided	108.289	112.772	1.0414
854	CPSF1	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
	NDUFS8	nadh-ubiquinone oxidoreductase 23 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-23kd) (ci-23kd) (tyky subunit). [swissprot;acc:o00217]	Subtracted	227.596	219.017	8.579
855	CLEC3B	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	Divided	178.514	171.42	1.04138
	ELOVL1	elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]	Subtracted	227.596	219.018	8.578
856	MYC	myc proto-oncogene protein (c-myc). [swissprot;acc:p01106]		227.585	219.037	8.548
	XPR1	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Divided	215.028	206.623	1.04068
857	MDN1	midasin (midas-containing protein). [swissprot;acc:q9nu22]	Subtracted	237.218	228.698	8.52
	PNO1	putatative 28 kda protein. [refseq;acc:nm_020143]	Divided	227.241	236.467	1.0406
858	SRP68	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	Subtracted	221.306	212.806	8.5
	STX12	syntaxin 12. [refseq;acc:nm_177424]	Divided	217.446	208.997	1.04043
859	no value	60s ribosomal protein l39. [swissprot;acc:p02404]		234.025	224.958	1.04031
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Subtracted	50.7983	42.3003	8.498
860		60s ribosomal protein l18a. [swissprot;acc:q02543]	Divided	234.025	224.958	1.04031
	NOL6	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	Subtracted	242.024	233.544	8.48
861	RPS19	40s ribosomal protein s19. [swissprot;acc:p39019]	Divided	234.025	224.958	1.04031
	STX12	syntaxin 12. [refseq;acc:nm_177424]	Subtracted	217.446	208.997	8.449
862	PKM2	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]		231.357	239.778	8.421
	RPL31	60s ribosomal protein l31. [swissprot;acc:p12947]	Divided	234.025	224.958	1.04031
863	CSNK2A1P	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]		240.194	230.957	1.03999
	XPR1	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Subtracted	215.028	206.623	8.405
864	CSNK2A2	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	Divided	240.194	230.957	1.03999
	EXOC4	exocyst complex component sec8. [swissprot;acc:q96a65]	Subtracted	217.762	209.449	8.313
865	BTF3	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	Divided	211.961	203.814	1.03997
	ZNF174	zinc finger protein 174 (aw-1). [swissprot;acc:q15697]	Subtracted	269.963	278.239	8.276
866	no value	zinc finger imprinted 2. [swissprot;acc:q9nzv7]		269.96	278.232	8.272
	SRP68	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	Divided	221.306	212.806	1.03994
867	no value	40s ribosomal protein s3a. [swissprot;acc:p49241]		225.689	234.674	1.03981
	ZNF18	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	Subtracted	269.956	278.223	8.267
868	MVD	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	Divided	233.298	242.571	1.03975
	ZNF215	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	Subtracted	269.956	278.223	8.267
869	EXOC4	exocyst complex component sec8. [swissprot;acc:q96a65]	Divided	217.762	209.449	1.03969
	ZNF24	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	Subtracted	269.955	278.221	8.266
870	no value	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	Divided	211.908	203.832	1.03962
	ZSCAN12	zinc finger protein 305. [swissprot;acc:o43309]	Subtracted	269.954	278.219	8.265
871	CPSF2	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Divided	110.2	114.552	1.03949
	ZNF232	zinc finger protein 232. [swissprot;acc:q9uny5]	Subtracted	269.954	278.218	8.264
872	HNRPK	heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244]	Divided	224.413	233.272	1.03948
	ZNF394	zinc finger protein 99. [refseq;acc:nm_032164]	Subtracted	269.954	278.218	8.264
873	PRPF4	u4/u6 small nuclear ribonucleoprotein prp4 (u4/u6 snrnp 60 kda protein) (wd splicing factor prp4) (hprp4). [swissprot;acc:o43172]	Divided	224.413	233.272	1.03948
	ZNF213	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	Subtracted	269.954	278.217	8.263
874	PRKAG1	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	Divided	212.002	203.954	1.03946
	ZNF274	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	Subtracted	269.953	278.215	8.262
875	JUP	junction plakoglobin (desmoplakin iii). [swissprot;acc:p14923]		223.906	215.653	8.253
	PRKAA2	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	Divided	212.002	203.954	1.03946

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.