MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1680 to 1729 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
840	TOMM20	mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	High confidence	198.781	190.66	1.04259
841	PEX19	peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]
	TYRP1	5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]	Low confidence	206.243	201.027	1.02595
842	CCDC22	jm1 protein. [refseq;acc:nm_014008]	High confidence	219.762	210.806	1.04248
	DCT	dopachrome tautomerase precursor (ec 5.3.3.12) (dt) (dct) (dopachrome delta-isomerase) (tyrosinase-related protein 2) (trp-2) (trp2). [swissprot;acc:p40126]	Low confidence	206.244	201.028	1.02595
843	GART	trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [swissprot;acc:p22102]	High confidence	218.521	227.796	1.04244
	LYPLA2P1	lysophospholipase ii; acyl-protein thioesterase. [refseq;acc:nm_007260]	Low confidence	194.47	189.552	1.02595
844	API5	apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]		194.659	189.74	1.02592
	CLEC3A	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	High confidence	178.033	170.82	1.04223
845	ALDH3B2	aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	Low confidence	209.59	215.023	1.02592
	LSM1	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	High confidence	228.599	219.399	1.04193
846	no value	methyltransferase like 2. [refseq;acc:nm_018396]		147.211	153.371	1.04184
	FOXO1	forkhead box protein o1a (forkhead in rhabdomyosarcoma). [swissprot;acc:q12778]	Low confidence	204.497	199.336	1.02589
847	DYNLT1	cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763]	High confidence	147.211	153.371	1.04184
	MLH3	dna mismatch repair protein mlh3 (mutl protein homolog 3). [swissprot;acc:q9uhc1]	Low confidence	203.643	198.505	1.02588
848	FZR1	fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	High confidence	147.211	153.371	1.04184
	SLC16A2	monocarboxylate transporter 8 (mct 8) (x-linked pest-containing transporter) (mct 7). [swissprot;acc:p36021]	Low confidence	181.638	177.058	1.02587
849	PCSK5	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]	High confidence	147.211	153.371	1.04184
	SLC16A10	solute carrier family 16 (monocarboxylic acid transporters), member 10; t-type amino acid transporter 1. [refseq;acc:nm_018593]	Low confidence	181.639	177.059	1.02587
850	CPSF4	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	High confidence	107.842	112.329	1.04161
	UBL4A	ubiquitin-like protein gdx (ubiquitin-like protein 4). [swissprot;acc:p11441]	Low confidence	197.337	192.361	1.02587
851	KIAA1012	trs85 homolog. [swissprot;acc:q9y2l5]	High confidence	107.842	112.329	1.04161
	POLS	polymerase (dna directed) sigma; topoisomerase-related function protein 4-1; polymerase (dna-directed) sigma. [refseq;acc:nm_006999]	Low confidence	203.191	198.072	1.02584
852	HPRT1	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	High confidence	193.114	185.412	1.04154
	TYR	tyrosinase precursor (ec 1.14.18.1) (monophenol monooxygenase) (tumor rejection antigen ab) (sk29-ab) (lb24-ab). [swissprot;acc:p14679]	Low confidence	206.174	200.983	1.02583
853	ACADVL	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]		199.788	194.759	1.02582
	WDR33	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	High confidence	108.289	112.772	1.0414
854	CPSF1	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
	QPRT	nicotinate-nucleotide pyrophosphorylase [carboxylating] (ec 2.4.2.19) (quinolinate phosphoribosyltransferase [decarboxylating]) (qaprtase) (qprtase). [swissprot;acc:q15274]	Low confidence	201.613	196.545	1.02579
855	CLEC3B	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	High confidence	178.514	171.42	1.04138
	HAGH	hydroxyacylglutathione hydrolase (ec 3.1.2.6) (glyoxalase ii) (glx ii). [swissprot;acc:q16775]	Low confidence	200.822	195.773	1.02579
856	SLC16A3	monocarboxylate transporter 4 (mct 4) (mct 3). [swissprot;acc:o15427]		183.826	179.209	1.02576
	XPR1	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	High confidence	215.028	206.623	1.04068
857	PNO1	putatative 28 kda protein. [refseq;acc:nm_020143]		227.241	236.467	1.0406
	PSMD1	26s proteasome non-atpase regulatory subunit 1 (26s proteasome regulatory subunit s1) (26s proteasome subunit p112). [swissprot;acc:q99460]	Low confidence	204.36	199.229	1.02575
858	SLC16A8	monocarboxylate transporter 3 (mct 3). [swissprot;acc:o95907]		183.673	179.063
	STX12	syntaxin 12. [refseq;acc:nm_177424]	High confidence	217.446	208.997	1.04043
859	no value	60s ribosomal protein l39. [swissprot;acc:p02404]		234.025	224.958	1.04031
	SLC16A1	monocarboxylate transporter 1 (mct 1). [swissprot;acc:p53985]	Low confidence	183.611	179.004	1.02574
860	no value	60s ribosomal protein l18a. [swissprot;acc:q02543]	High confidence	234.025	224.958	1.04031
	SLC16A5	monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375]	Low confidence	183.58	178.975	1.02573
861	RPS19	40s ribosomal protein s19. [swissprot;acc:p39019]	High confidence	234.025	224.958	1.04031
	SLC16A4	monocarboxylate transporter 5 (mct 5) (mct 4). [swissprot;acc:o15374]	Low confidence	200.605	195.573	1.02573
862	RPL31	60s ribosomal protein l31. [swissprot;acc:p12947]	High confidence	234.025	224.958	1.04031
	SLC16A7	monocarboxylate transporter 2 (mct 2). [swissprot;acc:o60669]	Low confidence	183.625	179.018	1.02573
863	CSNK2A1P	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	High confidence	240.194	230.957	1.03999
	NOL1	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	Low confidence	202.981	197.889	1.02573
864	CSNK2A2	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	High confidence	240.194	230.957	1.03999
	SLC16A6	monocarboxylate transporter 7 (mct 7) (mct 6). [swissprot;acc:o15403]	Low confidence	200.605	195.573	1.02573
865	BTF3	transcription factor btf3 (rna polymerase b transcription factor 3). [swissprot;acc:p20290]	High confidence	211.961	203.814	1.03997

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.